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• W3136392247 endingPage "2971" @default.
• W3136392247 startingPage "2971" @default.
• W3136392247 abstract "Besides its insulinotropic actions on pancreatic β cells, neuroprotective activities of glucagon-like peptide-1 (GLP-1) have attracted attention. The efficacy of a GLP-1 receptor (GLP-1R) agonist exendin-4 (Ex-4) for functional repair after sciatic nerve injury and amelioration of diabetic peripheral neuropathy (DPN) has been reported; however, the underlying mechanisms remain unclear. In this study, the bioactivities of Ex-4 on immortalized adult rat Schwann cells IFRS1 and adult rat dorsal root ganglion (DRG) neuron–IFRS1 co-culture system were investigated. Localization of GLP-1R in both DRG neurons and IFRS1 cells were confirmed using knockout-validated monoclonal Mab7F38 antibody. Treatment with 100 nM Ex-4 significantly enhanced survival/proliferation and migration of IFRS1 cells, as well as stimulated the movement of IFRS1 cells toward neurites emerging from DRG neuron cell bodies in the co-culture with the upregulation of myelin protein 22 and myelin protein zero. Because Ex-4 induced phosphorylation of serine/threonine-specific protein kinase AKT in these cells and its effects on DRG neurons and IFRS1 cells were attenuated by phosphatidyl inositol-3′-phosphate-kinase (PI3K) inhibitor LY294002, Ex-4 might act on both cells to activate PI3K/AKT signaling pathway, thereby promoting myelination in the co-culture. These findings imply the potential efficacy of Ex-4 toward DPN and other peripheral nerve lesions." @default.
• W3136392247 created "2021-03-29" @default.
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• W3136392247 date "2021-03-15" @default.
• W3136392247 modified "2023-09-27" @default.
• W3136392247 title "Exendin-4 Promotes Schwann Cell Survival/Migration and Myelination In Vitro" @default.
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• W3136392247 doi "https://doi.org/10.3390/ijms22062971" @default.
• W3136392247 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7999558" @default.
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• W3136392247 hasPublicationYear "2021" @default.
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