FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136394695> ?p ?o ?g. }

• W3136394695 endingPage "127969" @default.
• W3136394695 startingPage "127969" @default.
• W3136394695 abstract "The progress made so far in the elucidation of the structure of free fatty acid receptor 1 (FFAR1) and its secondary and ternary complexes with partial and full allosteric ligands led to the discovery of various putative binding regions on the FFAR1 surface. Attempts to develop FFAR1 agonists culminated with the identification of TAK-875 (1), whose phase 3 clinical trials were terminated due to potential liver toxicity. In the search of safer agonists, numerous classes of new compounds were designed, synthesized, and tested. Chemical decoration of the scaffolds was rationalized to reach a good balance between lipophilicity, activity, and toxicity. Today, targeting FFAR1 with positive modulators represents an attractive pharmacological tool for the treatment of type 2 diabetes mellitus (T2DM), mainly because of the lack of hypoglycaemic side effects associated with several antidiabetic drugs currently available. Moreover, considering the involvement of FFAR1 in many physio-pathological processes, its agonists are also emerging as possible therapeutic tools for alleviating organ inflammation and fibrosis, as well as for the treatment of CNS disorders, such as Alzheimer’s disease and dementia." @default.
• W3136394695 created "2021-03-29" @default.
• W3136394695 creator A5003329578 @default.
• W3136394695 creator A5015532308 @default.
• W3136394695 creator A5050767033 @default.
• W3136394695 creator A5082275152 @default.
• W3136394695 creator A5090705924 @default.
• W3136394695 date "2021-06-01" @default.
• W3136394695 modified "2023-10-10" @default.
• W3136394695 title "FFAR1/GPR40: One target, different binding sites, many agonists, no drugs, but a continuous and unprofitable tug-of-war between ligand lipophilicity, activity, and toxicity" @default.
• W3136394695 cites W1750654101 @default.
• W3136394695 cites W1974405795 @default.
• W3136394695 cites W1979161189 @default.
• W3136394695 cites W1982918806 @default.
• W3136394695 cites W1985487963 @default.
• W3136394695 cites W2048922467 @default.
• W3136394695 cites W2063245300 @default.
• W3136394695 cites W2128326754 @default.
• W3136394695 cites W2135148756 @default.
• W3136394695 cites W2148829653 @default.
• W3136394695 cites W2167706579 @default.
• W3136394695 cites W2254355725 @default.
• W3136394695 cites W2429754450 @default.
• W3136394695 cites W2520123270 @default.
• W3136394695 cites W2577526162 @default.
• W3136394695 cites W2577856100 @default.
• W3136394695 cites W2582287106 @default.
• W3136394695 cites W2587893840 @default.
• W3136394695 cites W2622916369 @default.
• W3136394695 cites W2766733934 @default.
• W3136394695 cites W2785444851 @default.
• W3136394695 cites W2790478674 @default.
• W3136394695 cites W2793485291 @default.
• W3136394695 cites W2801613715 @default.
• W3136394695 cites W2808718374 @default.
• W3136394695 cites W2895106561 @default.
• W3136394695 cites W2898665703 @default.
• W3136394695 cites W2921524066 @default.
• W3136394695 cites W2922353171 @default.
• W3136394695 cites W2937642362 @default.
• W3136394695 cites W2942691149 @default.
• W3136394695 cites W2944034821 @default.
• W3136394695 cites W2946148996 @default.
• W3136394695 cites W2948271948 @default.
• W3136394695 cites W2951097455 @default.
• W3136394695 cites W2955528026 @default.
• W3136394695 cites W2955575197 @default.
• W3136394695 cites W2962796147 @default.
• W3136394695 cites W2965429249 @default.
• W3136394695 cites W2967327218 @default.
• W3136394695 cites W2971877727 @default.
• W3136394695 cites W2971938956 @default.
• W3136394695 cites W2991475671 @default.
• W3136394695 cites W3000368163 @default.
• W3136394695 cites W3010106359 @default.
• W3136394695 cites W3016093134 @default.
• W3136394695 cites W3022011014 @default.
• W3136394695 cites W3022620811 @default.
• W3136394695 cites W3033851447 @default.
• W3136394695 cites W3034861903 @default.
• W3136394695 cites W3084275805 @default.
• W3136394695 cites W3128697892 @default.
• W3136394695 cites W923322911 @default.
• W3136394695 doi "https://doi.org/10.1016/j.bmcl.2021.127969" @default.
• W3136394695 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33771587" @default.
• W3136394695 hasPublicationYear "2021" @default.
• W3136394695 type Work @default.
• W3136394695 sameAs 3136394695 @default.
• W3136394695 citedByCount "13" @default.
• W3136394695 countsByYear W31363946952021 @default.
• W3136394695 countsByYear W31363946952022 @default.
• W3136394695 countsByYear W31363946952023 @default.
• W3136394695 crossrefType "journal-article" @default.
• W3136394695 hasAuthorship W3136394695A5003329578 @default.
• W3136394695 hasAuthorship W3136394695A5015532308 @default.
• W3136394695 hasAuthorship W3136394695A5050767033 @default.
• W3136394695 hasAuthorship W3136394695A5082275152 @default.
• W3136394695 hasAuthorship W3136394695A5090705924 @default.
• W3136394695 hasConcept C134018914 @default.
• W3136394695 hasConcept C166342909 @default.
• W3136394695 hasConcept C170493617 @default.
• W3136394695 hasConcept C178790620 @default.
• W3136394695 hasConcept C185592680 @default.
• W3136394695 hasConcept C2776054734 @default.
• W3136394695 hasConcept C2778918659 @default.
• W3136394695 hasConcept C2778938600 @default.
• W3136394695 hasConcept C2779934242 @default.
• W3136394695 hasConcept C29730261 @default.
• W3136394695 hasConcept C32670627 @default.
• W3136394695 hasConcept C41625074 @default.
• W3136394695 hasConcept C55493867 @default.
• W3136394695 hasConcept C555293320 @default.
• W3136394695 hasConcept C71924100 @default.
• W3136394695 hasConcept C74187038 @default.
• W3136394695 hasConcept C98274493 @default.
• W3136394695 hasConceptScore W3136394695C134018914 @default.
• W3136394695 hasConceptScore W3136394695C166342909 @default.
• W3136394695 hasConceptScore W3136394695C170493617 @default.

• next