FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136396630> ?p ?o ?g. }

• W3136396630 endingPage "2084" @default.
• W3136396630 startingPage "2075" @default.
• W3136396630 abstract "Colposcopy was referred in cases with severe abnormalities in co-testing. Although p16/Ki67 dual staining reduced the referral rate, its sensitivity and specificity need to be enhanced.The expressions of p16, Ki-67, SMAD3, YAP1, RELA were evaluated in the colposcopy referral population. The inclusion criteria included 30-60 years and diagnosed with HPV16/18-positive, other HR-HPV-positive with ASCUS, LSIL, AGC (atypical glandular cell) in co-testing. Colposcopies, endocervical curettages of cervical biopsies were also collected. Cases were excluded if there were no biopsies, if the interval between a cervical screening test and biopsies was more than 6 months, or if insufficient tissue was available as a formalin-fixed paraffin-embedded block. The pathology was independently reviewed by two pathologists. Discrepant interpretations were adjudicated by a third pathologist.In total, 1194 of 1273 cases who were referred to colposcopy were evaluated in the present study. The sensitivity and specificity of p16+ combined with Ki-67+ for predicting CIN2+ were 62.1% and 89.5%, respectively. p16+ combined with YAP1+ and/or RELA+ provided a sensitivity and specificity of 70.9% and 89.5%, respectively, while 72.8% and 86.4% were achieved by p16+ combined with YAP1+ and/or SMAD3+ and/or RELA+. In HPV16/18+ and LSIL subgroups, the sensitivity and specificity of p16+ combined with Ki-67+ for predicting CIN2+ were 67.7% and 87.6%, respectively, for the former group and 58.6%, 88.8%, respectively, for the latter group. p16+, YAP1+/RELA+ showed a better performance for predicting CIN2+ with a better sensitivity and considerable specificity in the other HPV+ combined with ASCUS group than were achieved by p16+ combined with Ki-67+. RELA+ and the combination of p16 and RELA/YAP1 also provided the Max AUC area.Our study shows that RELA and the combination of p16 and RELA/YAP1 achieved better sensitivity and specificity for detecting morphologically CIN2+ lesions." @default.
• W3136396630 created "2021-03-29" @default.
• W3136396630 creator A5017276130 @default.
• W3136396630 creator A5026373546 @default.
• W3136396630 creator A5046238628 @default.
• W3136396630 creator A5046777902 @default.
• W3136396630 creator A5047937368 @default.
• W3136396630 creator A5054709496 @default.
• W3136396630 creator A5060469228 @default.
• W3136396630 creator A5061332222 @default.
• W3136396630 creator A5068588368 @default.
• W3136396630 date "2021-03-01" @default.
• W3136396630 modified "2023-09-26" @default.
• W3136396630 title "Evaluation of Cervical High-Grade Squamous Intraepithelial Lesions-Correlated Markers as Triage Strategy for Colposcopy After Co-Testing" @default.
• W3136396630 cites W1536780471 @default.
• W3136396630 cites W1846382102 @default.
• W3136396630 cites W1899355776 @default.
• W3136396630 cites W1965054045 @default.
• W3136396630 cites W1981989535 @default.
• W3136396630 cites W2004785738 @default.
• W3136396630 cites W2006208922 @default.
• W3136396630 cites W2021649358 @default.
• W3136396630 cites W2034600951 @default.
• W3136396630 cites W2069943568 @default.
• W3136396630 cites W2110486727 @default.
• W3136396630 cites W2115256214 @default.
• W3136396630 cites W2117497925 @default.
• W3136396630 cites W2140566055 @default.
• W3136396630 cites W2141497495 @default.
• W3136396630 cites W2160798251 @default.
• W3136396630 cites W2172748090 @default.
• W3136396630 cites W2193328049 @default.
• W3136396630 cites W2235523093 @default.
• W3136396630 cites W2334883358 @default.
• W3136396630 cites W2335928577 @default.
• W3136396630 cites W2403965783 @default.
• W3136396630 cites W2518434407 @default.
• W3136396630 cites W2540586832 @default.
• W3136396630 cites W2551191591 @default.
• W3136396630 cites W2591512371 @default.
• W3136396630 cites W2601182341 @default.
• W3136396630 cites W2744412017 @default.
• W3136396630 cites W2789538306 @default.
• W3136396630 cites W2889646458 @default.
• W3136396630 cites W2990635021 @default.
• W3136396630 cites W3013365076 @default.
• W3136396630 cites W3015112546 @default.
• W3136396630 cites W3020989840 @default.
• W3136396630 cites W3048535327 @default.
• W3136396630 cites W4211002643 @default.
• W3136396630 doi "https://doi.org/10.2147/ott.s300269" @default.
• W3136396630 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7989978" @default.
• W3136396630 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33776454" @default.
• W3136396630 hasPublicationYear "2021" @default.
• W3136396630 type Work @default.
• W3136396630 sameAs 3136396630 @default.
• W3136396630 citedByCount "1" @default.
• W3136396630 countsByYear W31363966302023 @default.
• W3136396630 crossrefType "journal-article" @default.
• W3136396630 hasAuthorship W3136396630A5017276130 @default.
• W3136396630 hasAuthorship W3136396630A5026373546 @default.
• W3136396630 hasAuthorship W3136396630A5046238628 @default.
• W3136396630 hasAuthorship W3136396630A5046777902 @default.
• W3136396630 hasAuthorship W3136396630A5047937368 @default.
• W3136396630 hasAuthorship W3136396630A5054709496 @default.
• W3136396630 hasAuthorship W3136396630A5060469228 @default.
• W3136396630 hasAuthorship W3136396630A5061332222 @default.
• W3136396630 hasAuthorship W3136396630A5068588368 @default.
• W3136396630 hasBestOaLocation W31363966301 @default.
• W3136396630 hasConcept C121608353 @default.
• W3136396630 hasConcept C126322002 @default.
• W3136396630 hasConcept C142724271 @default.
• W3136396630 hasConcept C174618031 @default.
• W3136396630 hasConcept C2775934546 @default.
• W3136396630 hasConcept C2776117191 @default.
• W3136396630 hasConcept C2776511402 @default.
• W3136396630 hasConcept C2777083264 @default.
• W3136396630 hasConcept C2777343196 @default.
• W3136396630 hasConcept C2778220009 @default.
• W3136396630 hasConcept C29456083 @default.
• W3136396630 hasConcept C59822182 @default.
• W3136396630 hasConcept C71924100 @default.
• W3136396630 hasConcept C86803240 @default.
• W3136396630 hasConcept C90924648 @default.
• W3136396630 hasConceptScore W3136396630C121608353 @default.
• W3136396630 hasConceptScore W3136396630C126322002 @default.
• W3136396630 hasConceptScore W3136396630C142724271 @default.
• W3136396630 hasConceptScore W3136396630C174618031 @default.
• W3136396630 hasConceptScore W3136396630C2775934546 @default.
• W3136396630 hasConceptScore W3136396630C2776117191 @default.
• W3136396630 hasConceptScore W3136396630C2776511402 @default.
• W3136396630 hasConceptScore W3136396630C2777083264 @default.
• W3136396630 hasConceptScore W3136396630C2777343196 @default.
• W3136396630 hasConceptScore W3136396630C2778220009 @default.
• W3136396630 hasConceptScore W3136396630C29456083 @default.
• W3136396630 hasConceptScore W3136396630C59822182 @default.
• W3136396630 hasConceptScore W3136396630C71924100 @default.
• W3136396630 hasConceptScore W3136396630C86803240 @default.

• next