FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136403354> ?p ?o ?g. }

• W3136403354 abstract "Background: Selecting proper postoperative adjuvant therapy is of great importance for prolonging overall survival (OS) of patients with biliary tract cancer (BTC). OS is commonly affected by high rate of postoperative recurrence and metastasis. Purpose: The present study aimed to identify the optimal adjuvant therapy for BTC patients. Method: A comprehensive search was carried out on Pubmed, Web of science, and Embase databases to acquire articles regarding BTC therapy approaches. Subsequently, the hazard ratio (HR) and its 95% confidence intervals (CIs) were applied to evaluate the efficacy of different adjuvant therapy regimens. The GemTc (GemTc.0.8-2) and R (R.3.6.0) software were employed to perform statistical analyses. Result: Data from 22 articles, including 14,646 patients, were quantitatively analyzed. The results showed that in terms of 5-year OS, gemcitabine (GEM) was considered as the optimal adjuvant therapy for BTC compared with chemoradiotherapy (CRT; HR = 0.59; 95% CI = 0.34-0.97), observation (OB; HR = 0.49; 95% CI = 0.33-0.73), and radiotherapy (RT; HR = 0.40; 95% CI = 0.22-0.71). Additionally, 5-fluorouracil (5-FU) exhibited improved efficacy compared with RT (HR = 0.52; 95% CI = 0.29-0.91) and OB (HR = 0.63; 95% CI = 0.43-0.92). When the efficacy of 5-FU was compared with that of GEM, the results showed that 5-FU (HR = 1.29) was more effective than GEM. Furthermore, CRT and RT prolonged positive resection margin (R + )-OS (HR = 0.69; 95% CI = 0.49-1.00) and positive lymph node-(N + )-OS (HR = 0.22; 95% CI = 0.074-0.66) in BTC patients. In terms of median recurrence-free survival (RFS) and 1-year OS, the differences were not statistically significant among different therapeutic interventions. Conclusion: The present study suggested that GEM could be used as a first-line adjuvant therapy for resected BTC patients. Additionally, CRT could be the optimal treatment approach for R + and N + patients." @default.
• W3136403354 created "2021-03-29" @default.
• W3136403354 creator A5036550250 @default.
• W3136403354 creator A5053225394 @default.
• W3136403354 creator A5061898071 @default.
• W3136403354 creator A5065972394 @default.
• W3136403354 date "2021-03-11" @default.
• W3136403354 modified "2023-09-24" @default.
• W3136403354 title "Adjuvant Therapy for Resectable Biliary Tract Cancer: A Bayesian Network Analysis" @default.
• W3136403354 cites W1001076389 @default.
• W3136403354 cites W1462655872 @default.
• W3136403354 cites W1486884945 @default.
• W3136403354 cites W1617328014 @default.
• W3136403354 cites W1902115884 @default.
• W3136403354 cites W1967385770 @default.
• W3136403354 cites W1976103879 @default.
• W3136403354 cites W1985334064 @default.
• W3136403354 cites W1992149176 @default.
• W3136403354 cites W1992370111 @default.
• W3136403354 cites W1992447918 @default.
• W3136403354 cites W1999437680 @default.
• W3136403354 cites W2004215162 @default.
• W3136403354 cites W2005961536 @default.
• W3136403354 cites W2008511899 @default.
• W3136403354 cites W2009253656 @default.
• W3136403354 cites W2011387799 @default.
• W3136403354 cites W2021711837 @default.
• W3136403354 cites W2025590891 @default.
• W3136403354 cites W2030921519 @default.
• W3136403354 cites W2042893050 @default.
• W3136403354 cites W2061397044 @default.
• W3136403354 cites W2075642745 @default.
• W3136403354 cites W2085803274 @default.
• W3136403354 cites W2088095316 @default.
• W3136403354 cites W2088817713 @default.
• W3136403354 cites W2098923148 @default.
• W3136403354 cites W2103810349 @default.
• W3136403354 cites W2116475791 @default.
• W3136403354 cites W2118002846 @default.
• W3136403354 cites W2126634195 @default.
• W3136403354 cites W2126930838 @default.
• W3136403354 cites W2146621833 @default.
• W3136403354 cites W2148899606 @default.
• W3136403354 cites W2155689551 @default.
• W3136403354 cites W2157318188 @default.
• W3136403354 cites W2257602259 @default.
• W3136403354 cites W2406760685 @default.
• W3136403354 cites W2517846777 @default.
• W3136403354 cites W2526881395 @default.
• W3136403354 cites W2531269403 @default.
• W3136403354 cites W2606143608 @default.
• W3136403354 cites W2734150112 @default.
• W3136403354 cites W2755449066 @default.
• W3136403354 cites W2761031851 @default.
• W3136403354 cites W2894658329 @default.
• W3136403354 cites W2914858130 @default.
• W3136403354 cites W2922052285 @default.
• W3136403354 cites W2923282967 @default.
• W3136403354 cites W4211025847 @default.
• W3136403354 cites W4236234748 @default.
• W3136403354 doi "https://doi.org/10.3389/fonc.2021.600027" @default.
• W3136403354 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7991284" @default.
• W3136403354 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33777744" @default.
• W3136403354 hasPublicationYear "2021" @default.
• W3136403354 type Work @default.
• W3136403354 sameAs 3136403354 @default.
• W3136403354 citedByCount "3" @default.
• W3136403354 countsByYear W31364033542022 @default.
• W3136403354 crossrefType "journal-article" @default.
• W3136403354 hasAuthorship W3136403354A5036550250 @default.
• W3136403354 hasAuthorship W3136403354A5053225394 @default.
• W3136403354 hasAuthorship W3136403354A5061898071 @default.
• W3136403354 hasAuthorship W3136403354A5065972394 @default.
• W3136403354 hasBestOaLocation W31364033541 @default.
• W3136403354 hasConcept C121608353 @default.
• W3136403354 hasConcept C126322002 @default.
• W3136403354 hasConcept C143998085 @default.
• W3136403354 hasConcept C207103383 @default.
• W3136403354 hasConcept C2777863537 @default.
• W3136403354 hasConcept C2777982462 @default.
• W3136403354 hasConcept C2778424827 @default.
• W3136403354 hasConcept C2780258809 @default.
• W3136403354 hasConcept C3017919176 @default.
• W3136403354 hasConcept C44249647 @default.
• W3136403354 hasConcept C509974204 @default.
• W3136403354 hasConcept C71924100 @default.
• W3136403354 hasConcept C90924648 @default.
• W3136403354 hasConceptScore W3136403354C121608353 @default.
• W3136403354 hasConceptScore W3136403354C126322002 @default.
• W3136403354 hasConceptScore W3136403354C143998085 @default.
• W3136403354 hasConceptScore W3136403354C207103383 @default.
• W3136403354 hasConceptScore W3136403354C2777863537 @default.
• W3136403354 hasConceptScore W3136403354C2777982462 @default.
• W3136403354 hasConceptScore W3136403354C2778424827 @default.
• W3136403354 hasConceptScore W3136403354C2780258809 @default.
• W3136403354 hasConceptScore W3136403354C3017919176 @default.
• W3136403354 hasConceptScore W3136403354C44249647 @default.
• W3136403354 hasConceptScore W3136403354C509974204 @default.
• W3136403354 hasConceptScore W3136403354C71924100 @default.
• W3136403354 hasConceptScore W3136403354C90924648 @default.

• next