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- W3136403879 abstract "Epidermal growth factor receptor (EGFR) represents the first identified targetable oncogenic driver discovered in NSCLC. Approximately 40% of Asian patients with newly diagnosed metastatic NSCLC harbor a somatic mutation in the EGFR gene. Next generation sequencing (NGS) has been widely used to detect EGFR mutations in NSCLC, and rare alterations of EGFR including point mutations, gene fusions and kinase domain duplication (KDD) were identified. Herein, we describe here the use of NGS to identify one EGFR kinase domain duplication (EGFR-KDD) mutation in a patient with lung adenocarcinoma responding to afatinib. Next-generation sequencing (NGS) on the liquid biopsy were performed. A 66-year-old patient underwent a CT scan that revealed solid nodules in the right lobe of the lung, and cancer was suspected as the cause. Metabolic imaging further indicated malignant lesions in the lower lobe of the right lung accompanied by mediastinal lymph node metastasis. However, the patient declined further examination or treatment for unknown reasons and was not readmitted to the hospital until 2 year later when the patient complained of chest pain and increased pleural effusion. Cancer cells were found in the pleural effusion, and a pathological diagnosis of lung adenocarcinoma was made. Cisplatin plus pemetrexed was administered, which was subsequently changed to nedaplatin plus pemetrexed after the disease progressed. In order to seek potential therapeutic regimens, peripheral blood circulating free DNA (cfDNA) was subjected to NGS analysis, one EGFR-KDD with duplication of exons 18-26 was identified. Based on these findings, the patient was administered with afatinib immediately from Jun. 2019. Several follow-up visits were conducted, and the last visit was in Mar. 2020, which showed tumor lesion in both lungs and right pleura still kept stable and the OS already exceeded 9 months. EGFR-KDD with duplication of exons 18-26, which firstly be reported in glioma and so far it was the first case with lung adenocarcinoma harboring this alteration. Afatinib may be a beneficial therapeutic option for a subset of NSCLC with rare EGFR co-mutation. Our case report expands the spectrum of knowledge regarding EGFR-KDD mutants in NSCLC and provides useful information for more precise EGFR-TKI therapies in the future." @default.
- W3136403879 created "2021-03-29" @default.
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- W3136403879 date "2021-03-01" @default.
- W3136403879 modified "2023-10-14" @default.
- W3136403879 title "P76.21 EGFR-KDD with Duplication of Exons 18-26 Responding to Afatinib Treatment in a Patient with Lung Adenocarcinoma" @default.
- W3136403879 doi "https://doi.org/10.1016/j.jtho.2021.01.1078" @default.
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