FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136407144> ?p ?o ?g. }

• W3136407144 abstract "Abstract Background Distant metastasis is the leading cause of death for esophageal squamous cell carcinoma (ESCC) with limited treatment options and unsatisfactory effectiveness. Bromodomain (BRD) containing proteins are emerging targets for cancer therapy with promising effects. As a unique member of BRD family, the function and molecular mechanism of ATAD2 in cancer development is seldomly investigated. Methods The clinical impact of ATAD2 was assessed both at RNA and protein level in 75 and 112 ESCC patients separately. The biological function of ATAD2 was investigated in vitro and in vivo. Signaling pathway and downstream effectors of ATAD2 were identified by RNA sequencing, luciferase reporter, co-immunoprecipitation, chromatin immunoprecipitation, immunofluorescence and western blot assay. Results We found that elevated ATAD2 expression was significantly associated with lymph node metastasis, advanced clinical stage as well as poor survival of ESCC patients. Silencing ATAD2 significantly suppressed ESCC cell migration and invasion in vitro, and inhibited tumor growth and lung metastasis in vivo. Mechanically, we identified a new cofactor, C/EBPβ. ATAD2 directly interacted with C/EBPβ and promoted its nuclear translocation, which directly bound to the promoter region of TGF-β1 and activated its expression. Further, we demonstrated that TGF-β1 activated its downstream effectors in a Smad3 dependent manner. In addition, we further found that ATAD2 promoted ESCC metastasis through TGF-β signaling induced Snail expression and the subsequent epithelial-mesenchymal transition. Conclusion Our findings demonstrated the pro-metastatic function of ATAD2 and uncovered the new molecular mechanism by regulating C/EBPβ/TGF-β1/Smad3/Snail signaling pathway, thus providing a potential target for the treatment of ESCC metastasis." @default.
• W3136407144 created "2021-03-29" @default.
• W3136407144 creator A5001330715 @default.
• W3136407144 creator A5014766280 @default.
• W3136407144 creator A5023454415 @default.
• W3136407144 creator A5035843058 @default.
• W3136407144 creator A5052129250 @default.
• W3136407144 creator A5053512092 @default.
• W3136407144 creator A5057369666 @default.
• W3136407144 creator A5064872044 @default.
• W3136407144 creator A5074316326 @default.
• W3136407144 creator A5075261187 @default.
• W3136407144 creator A5076788807 @default.
• W3136407144 date "2021-03-23" @default.
• W3136407144 modified "2023-10-18" @default.
• W3136407144 title "ATAD2 interacts with C/EBPβ to promote esophageal squamous cell carcinoma metastasis via TGF-β1/Smad3 signaling" @default.
• W3136407144 cites W1620051969 @default.
• W3136407144 cites W1818747732 @default.
• W3136407144 cites W1974266360 @default.
• W3136407144 cites W1980582708 @default.
• W3136407144 cites W2000315116 @default.
• W3136407144 cites W2004233711 @default.
• W3136407144 cites W2039998866 @default.
• W3136407144 cites W2067273727 @default.
• W3136407144 cites W2072110656 @default.
• W3136407144 cites W2084474293 @default.
• W3136407144 cites W2085648246 @default.
• W3136407144 cites W2106940478 @default.
• W3136407144 cites W2123647733 @default.
• W3136407144 cites W2162373413 @default.
• W3136407144 cites W2164169972 @default.
• W3136407144 cites W2184483246 @default.
• W3136407144 cites W2527634451 @default.
• W3136407144 cites W2568322231 @default.
• W3136407144 cites W2570763587 @default.
• W3136407144 cites W2705435067 @default.
• W3136407144 cites W2770554590 @default.
• W3136407144 cites W2790987002 @default.
• W3136407144 cites W2798233554 @default.
• W3136407144 cites W2887087746 @default.
• W3136407144 cites W2898466121 @default.
• W3136407144 cites W2900395978 @default.
• W3136407144 cites W2906037756 @default.
• W3136407144 cites W2914048378 @default.
• W3136407144 cites W2953873379 @default.
• W3136407144 cites W2958392354 @default.
• W3136407144 cites W2960484170 @default.
• W3136407144 cites W2967496768 @default.
• W3136407144 cites W2973561030 @default.
• W3136407144 cites W2977622329 @default.
• W3136407144 cites W2984891373 @default.
• W3136407144 cites W2998853215 @default.
• W3136407144 cites W2999417355 @default.
• W3136407144 cites W3000384995 @default.
• W3136407144 cites W3001038414 @default.
• W3136407144 cites W3012240350 @default.
• W3136407144 doi "https://doi.org/10.1186/s13046-021-01905-x" @default.
• W3136407144 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7986551" @default.
• W3136407144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33757572" @default.
• W3136407144 hasPublicationYear "2021" @default.
• W3136407144 type Work @default.
• W3136407144 sameAs 3136407144 @default.
• W3136407144 citedByCount "16" @default.
• W3136407144 countsByYear W31364071442022 @default.
• W3136407144 countsByYear W31364071442023 @default.
• W3136407144 crossrefType "journal-article" @default.
• W3136407144 hasAuthorship W3136407144A5001330715 @default.
• W3136407144 hasAuthorship W3136407144A5014766280 @default.
• W3136407144 hasAuthorship W3136407144A5023454415 @default.
• W3136407144 hasAuthorship W3136407144A5035843058 @default.
• W3136407144 hasAuthorship W3136407144A5052129250 @default.
• W3136407144 hasAuthorship W3136407144A5053512092 @default.
• W3136407144 hasAuthorship W3136407144A5057369666 @default.
• W3136407144 hasAuthorship W3136407144A5064872044 @default.
• W3136407144 hasAuthorship W3136407144A5074316326 @default.
• W3136407144 hasAuthorship W3136407144A5075261187 @default.
• W3136407144 hasAuthorship W3136407144A5076788807 @default.
• W3136407144 hasBestOaLocation W31364071441 @default.
• W3136407144 hasConcept C101762097 @default.
• W3136407144 hasConcept C104317684 @default.
• W3136407144 hasConcept C119056186 @default.
• W3136407144 hasConcept C121608353 @default.
• W3136407144 hasConcept C134320426 @default.
• W3136407144 hasConcept C137738243 @default.
• W3136407144 hasConcept C1491633281 @default.
• W3136407144 hasConcept C150194340 @default.
• W3136407144 hasConcept C185592680 @default.
• W3136407144 hasConcept C2779013556 @default.
• W3136407144 hasConcept C502942594 @default.
• W3136407144 hasConcept C54355233 @default.
• W3136407144 hasConcept C55493867 @default.
• W3136407144 hasConcept C62112901 @default.
• W3136407144 hasConcept C62478195 @default.
• W3136407144 hasConcept C76419328 @default.
• W3136407144 hasConcept C86803240 @default.
• W3136407144 hasConcept C95444343 @default.
• W3136407144 hasConceptScore W3136407144C101762097 @default.
• W3136407144 hasConceptScore W3136407144C104317684 @default.
• W3136407144 hasConceptScore W3136407144C119056186 @default.
• W3136407144 hasConceptScore W3136407144C121608353 @default.

• next