FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136408290> ?p ?o ?g. }

• W3136408290 abstract "Candida albicans is a part of the normal microbiome of human mucosa and is able to thrive in a wide range of host environments. As an opportunistic pathogen, the virulence of C. albicans is tied to its ability to switch between yeast and hyphal morphologies in response to various environmental cues, one of which includes nutrient availability. Thus, metabolic flexibility plays an important role in the virulence of the pathogen. Our previous study has shown that C. albicans Yeast Casein Kinase 2 (CaYck2) regulates the yeast-to-hyphal switch, but its regulatory mechanisms remain unknown. This study further elucidated the role of Yck2 in governing morphology and carbon metabolism by analyzing the transcriptome and metabolome of the C. albicans YCK2 deletion mutant strain ( yck2 Δ strain) in comparison to the wild type strain. Our study revealed that loss of CaYck2 perturbs carbon metabolism, leading to a transcriptional response that resembles a transcriptional response to glucose starvation with coinciding intracellular accumulation of glucose and depletion of TCA cycle metabolites. This shift in the metabolome is likely mediated by derepression of glucose-repressed genes in the Mig1/2-mediated glucose sensing pathway and by downregulation of glycolytic genes, possibly through the Rgt1-mediated SRR pathway. In addition, genes involved in beta-oxidation, glyoxylate cycle, oxidative stress response, and arginine biosynthesis were upregulated in the yck2 Δ strain, which is highly reminiscent of C. albicans engulfment by macrophages. This coincides with an increase in arginine degradation intermediates in the yck2 Δ strain, suggesting arginine catabolism as a potential mechanism of CaYck2-mediated filamentation as seen during C. albicans escape from macrophages. Transcriptome analysis also shows differential expression of hyphal transcriptional regulators Nrg1 and Ume6. This suggests dysregulation of hyphal initiation and elongation in the yck2 Δ strain which may lead to the constitutive pseudohyphal phenotype of this strain. Metabolome analysis also detected a high abundance of methyl citrate cycle intermediates in the yck2 Δ strain, suggesting the importance of CaYck2 in this pathway. Taken together, we discovered that CaYck2 is an integral piece of carbon metabolism and morphogenesis of C. albicans ." @default.
• W3136408290 created "2021-03-29" @default.
• W3136408290 creator A5000305778 @default.
• W3136408290 creator A5001318973 @default.
• W3136408290 creator A5026801041 @default.
• W3136408290 creator A5031518069 @default.
• W3136408290 creator A5051546694 @default.
• W3136408290 creator A5059870616 @default.
• W3136408290 creator A5073611891 @default.
• W3136408290 date "2021-03-16" @default.
• W3136408290 modified "2023-10-02" @default.
• W3136408290 title "Transcriptomic and Metabolomic Analysis Revealed Roles of Yck2 in Carbon Metabolism and Morphogenesis of Candida albicans" @default.
• W3136408290 cites W1505743758 @default.
• W3136408290 cites W1506397644 @default.
• W3136408290 cites W1617495083 @default.
• W3136408290 cites W1632467620 @default.
• W3136408290 cites W1647692986 @default.
• W3136408290 cites W1881030466 @default.
• W3136408290 cites W1969395447 @default.
• W3136408290 cites W1982151856 @default.
• W3136408290 cites W1986207589 @default.
• W3136408290 cites W2004054808 @default.
• W3136408290 cites W2012034776 @default.
• W3136408290 cites W2030271109 @default.
• W3136408290 cites W2035287841 @default.
• W3136408290 cites W2036897871 @default.
• W3136408290 cites W2036913140 @default.
• W3136408290 cites W2048093614 @default.
• W3136408290 cites W2057569736 @default.
• W3136408290 cites W2058459698 @default.
• W3136408290 cites W2059819778 @default.
• W3136408290 cites W2073175848 @default.
• W3136408290 cites W2080592587 @default.
• W3136408290 cites W2095982497 @default.
• W3136408290 cites W2098977307 @default.
• W3136408290 cites W2105087827 @default.
• W3136408290 cites W2105735515 @default.
• W3136408290 cites W2108234281 @default.
• W3136408290 cites W2109403646 @default.
• W3136408290 cites W2109483151 @default.
• W3136408290 cites W2110874942 @default.
• W3136408290 cites W2118323304 @default.
• W3136408290 cites W2119749825 @default.
• W3136408290 cites W2121322589 @default.
• W3136408290 cites W2122960738 @default.
• W3136408290 cites W2123240988 @default.
• W3136408290 cites W2131942193 @default.
• W3136408290 cites W2132171565 @default.
• W3136408290 cites W2133644564 @default.
• W3136408290 cites W2135707527 @default.
• W3136408290 cites W2146862754 @default.
• W3136408290 cites W2152383582 @default.
• W3136408290 cites W2157151790 @default.
• W3136408290 cites W2160471163 @default.
• W3136408290 cites W2162598371 @default.
• W3136408290 cites W2166526638 @default.
• W3136408290 cites W2510875395 @default.
• W3136408290 cites W2519870106 @default.
• W3136408290 cites W2767885461 @default.
• W3136408290 cites W2772906561 @default.
• W3136408290 cites W2805839117 @default.
• W3136408290 cites W2900719263 @default.
• W3136408290 cites W2950010168 @default.
• W3136408290 cites W2953808571 @default.
• W3136408290 cites W2961041839 @default.
• W3136408290 cites W2993072965 @default.
• W3136408290 cites W3001698320 @default.
• W3136408290 cites W3028833267 @default.
• W3136408290 doi "https://doi.org/10.3389/fcimb.2021.636834" @default.
• W3136408290 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8008151" @default.
• W3136408290 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33796481" @default.
• W3136408290 hasPublicationYear "2021" @default.
• W3136408290 type Work @default.
• W3136408290 sameAs 3136408290 @default.
• W3136408290 citedByCount "10" @default.
• W3136408290 countsByYear W31364082902022 @default.
• W3136408290 countsByYear W31364082902023 @default.
• W3136408290 crossrefType "journal-article" @default.
• W3136408290 hasAuthorship W3136408290A5000305778 @default.
• W3136408290 hasAuthorship W3136408290A5001318973 @default.
• W3136408290 hasAuthorship W3136408290A5026801041 @default.
• W3136408290 hasAuthorship W3136408290A5031518069 @default.
• W3136408290 hasAuthorship W3136408290A5051546694 @default.
• W3136408290 hasAuthorship W3136408290A5059870616 @default.
• W3136408290 hasAuthorship W3136408290A5073611891 @default.
• W3136408290 hasBestOaLocation W31364082901 @default.
• W3136408290 hasConcept C104317684 @default.
• W3136408290 hasConcept C135870905 @default.
• W3136408290 hasConcept C143065580 @default.
• W3136408290 hasConcept C145081991 @default.
• W3136408290 hasConcept C150194340 @default.
• W3136408290 hasConcept C162317418 @default.
• W3136408290 hasConcept C2777477808 @default.
• W3136408290 hasConcept C2780917455 @default.
• W3136408290 hasConcept C55493867 @default.
• W3136408290 hasConcept C86803240 @default.
• W3136408290 hasConcept C89423630 @default.
• W3136408290 hasConcept C95444343 @default.
• W3136408290 hasConceptScore W3136408290C104317684 @default.
• W3136408290 hasConceptScore W3136408290C135870905 @default.

• next