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• W3136412154 abstract "Surrogate β-cells derived from available adult stem cells are urgently needed for the treatment of insulindeficient diabetes, and hepatocytes constitute an attractive alternative. Herein, we attempted to generate insulin-producing cells from adult mouse primary hepatocytes (HCs) using triple adenoviruses harboring PDX-1/VP-16, BETA2, and MafA. We noted characteristic changes in the transduced HCs into pancreatic β-cells, including reduced albumin gene and increased insulin, insulin content, and the expression of a variety of pancreatic genes. Glucose tolerance and survival are improved by the renal capsular transplantation. These data demonstrated that the transdifferentiation of HCs into insulin-producing cells could be achieved under both in vitro and in vivo conditions. Further, these data suggest that induction of insulin-producing cells from liver provides a potential cell-replacement therapy for the treatment of patients with diabetes using alternative transplantable cell source." @default.
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• W3136412154 date "2011-01-01" @default.
• W3136412154 modified "2023-09-22" @default.
• W3136412154 title "Original Article : Generation of Insulin Producing Cells from the Mouse Primary Hepatocytes" @default.
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