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• W3136415275 abstract "Abstract Background Regulation of protein output at the level of translation allows for a rapid adaptation to dynamic changes to the cell’s requirements. This precise control of gene expression is achieved by complex and interlinked biochemical processes that modulate both the protein synthesis rate and stability of each individual mRNA. A major factor coordinating this regulation is the Ccr4-Not complex. Despite playing a role in most stages of the mRNA life cycle, no attempt has been made to take a global integrated view of how the Ccr4-Not complex affects gene expression. Results This study has taken a comprehensive approach to investigate post-transcriptional regulation mediated by the Ccr4-Not complex assessing steady-state mRNA levels, ribosome position, mRNA stability and protein production transcriptome-wide. Depletion of the scaffold protein CNOT1 results in a global upregulation of mRNA stability and the preferential stabilisation of mRNAs enriched for G/C-ending codons. We also uncover that mRNAs targeted to the ER for their translation have reduced translational efficiency when CNOT1 is depleted, specifically downstream of the signal sequence cleavage site. In contrast, translationally upregulated mRNAs are normally localised in p-bodies, contain disorder-promoting amino acids and encode nuclear localised proteins. Finally, we identify ribosome pause sites that are resolved or induced by the depletion of CNOT1. Conclusion We define the key mRNA features that determine how the human Ccr4-Not complex differentially regulates mRNA fate and protein synthesis through a mechanism linked to codon composition, amino acid usage, and mRNA localisation." @default.
• W3136415275 created "2021-03-29" @default.
• W3136415275 creator A5005620487 @default.
• W3136415275 creator A5025878901 @default.
• W3136415275 creator A5034439286 @default.
• W3136415275 creator A5066434421 @default.
• W3136415275 creator A5083247102 @default.
• W3136415275 date "2021-03-13" @default.
• W3136415275 modified "2023-10-10" @default.
• W3136415275 title "Differential regulation of mRNA fate by the human Ccr4-Not complex is driven by CDS composition and mRNA localisation" @default.
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