Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136430911> ?p ?o ?g. }
- W3136430911 abstract "Severe acute respiratory syndrome related coronavirus-2 (SARS-CoV-2) is the cause of Covid-19 which was classified as a global pandemic in March 2020. The increasing global health and economic burden of SARS-CoV-2 has necessitated urgent investigations into the pathogenesis of disease and development of therapeutic and vaccination regimens. Human trials of vaccine and antiviral candidates have been undertaken, but basic pathogenetic studies are still required to inform these trials. Gaps in understanding of cellular infection by, and immunity to, SARS-CoV-2 mean additional models are required to assist in improved design of these therapeutics. Human organoids are three-dimensional models that contain multiple cell types and mimic human organs in ex vivo culture conditions. The SARS-CoV-2 virus has been implicated in causing not only respiratory injury but also injury to other organs such as the brain, liver and kidneys. Consequently, a variety of different organoid models have been employed to investigate the pathogenic mechanisms of disease due to SARS-CoV-2. Data on these models have not been systematically assembled. In this review, we highlight key findings from studies that have utilised different human organoid types to investigate the expression of SARS-CoV-2 receptors, permissiveness, immune response, dysregulation of cellular functions, and potential antiviral therapeutics." @default.
- W3136430911 created "2021-03-29" @default.
- W3136430911 creator A5010530875 @default.
- W3136430911 creator A5064552386 @default.
- W3136430911 date "2021-03-25" @default.
- W3136430911 modified "2023-09-25" @default.
- W3136430911 title "Review of studies of severe acute respiratory syndrome related coronavirus–2 pathogenesis in human organoid models" @default.
- W3136430911 cites W1483496013 @default.
- W3136430911 cites W1552434751 @default.
- W3136430911 cites W1643680178 @default.
- W3136430911 cites W1966556466 @default.
- W3136430911 cites W1973160402 @default.
- W3136430911 cites W1985958520 @default.
- W3136430911 cites W2002513358 @default.
- W3136430911 cites W2036755018 @default.
- W3136430911 cites W2044928246 @default.
- W3136430911 cites W2081837126 @default.
- W3136430911 cites W2088534886 @default.
- W3136430911 cites W2090258227 @default.
- W3136430911 cites W2093402003 @default.
- W3136430911 cites W2156093068 @default.
- W3136430911 cites W2158118659 @default.
- W3136430911 cites W2165022280 @default.
- W3136430911 cites W2176475383 @default.
- W3136430911 cites W2185034389 @default.
- W3136430911 cites W223176005 @default.
- W3136430911 cites W2267315119 @default.
- W3136430911 cites W2341041396 @default.
- W3136430911 cites W2345170379 @default.
- W3136430911 cites W2563494429 @default.
- W3136430911 cites W2610356532 @default.
- W3136430911 cites W2753321278 @default.
- W3136430911 cites W2766233026 @default.
- W3136430911 cites W2799560469 @default.
- W3136430911 cites W2809835772 @default.
- W3136430911 cites W2892551532 @default.
- W3136430911 cites W2901282399 @default.
- W3136430911 cites W2903899730 @default.
- W3136430911 cites W2904111838 @default.
- W3136430911 cites W2904130550 @default.
- W3136430911 cites W2949020598 @default.
- W3136430911 cites W2964772567 @default.
- W3136430911 cites W2973521744 @default.
- W3136430911 cites W3000834295 @default.
- W3136430911 cites W3004318991 @default.
- W3136430911 cites W3004345103 @default.
- W3136430911 cites W3007643904 @default.
- W3136430911 cites W3008090866 @default.
- W3136430911 cites W3009335299 @default.
- W3136430911 cites W3009912996 @default.
- W3136430911 cites W3010897008 @default.
- W3136430911 cites W3010940342 @default.
- W3136430911 cites W3011483298 @default.
- W3136430911 cites W3011508332 @default.
- W3136430911 cites W3012907222 @default.
- W3136430911 cites W3013047097 @default.
- W3136430911 cites W3013374708 @default.
- W3136430911 cites W3015280639 @default.
- W3136430911 cites W3016489853 @default.
- W3136430911 cites W3016710356 @default.
- W3136430911 cites W3016829967 @default.
- W3136430911 cites W3016923936 @default.
- W3136430911 cites W3017730472 @default.
- W3136430911 cites W3020655133 @default.
- W3136430911 cites W3020695284 @default.
- W3136430911 cites W3020909574 @default.
- W3136430911 cites W3023103130 @default.
- W3136430911 cites W3023986730 @default.
- W3136430911 cites W3024126428 @default.
- W3136430911 cites W3024439234 @default.
- W3136430911 cites W3024445339 @default.
- W3136430911 cites W3025129816 @default.
- W3136430911 cites W3025559601 @default.
- W3136430911 cites W3027630905 @default.
- W3136430911 cites W3028598886 @default.
- W3136430911 cites W3030748957 @default.
- W3136430911 cites W3030871984 @default.
- W3136430911 cites W3036500399 @default.
- W3136430911 cites W3036741019 @default.
- W3136430911 cites W3036784522 @default.
- W3136430911 cites W3037368719 @default.
- W3136430911 cites W3037455818 @default.
- W3136430911 cites W3037794751 @default.
- W3136430911 cites W3040646360 @default.
- W3136430911 cites W3040801404 @default.
- W3136430911 cites W3041348343 @default.
- W3136430911 cites W3044040393 @default.
- W3136430911 cites W3045724532 @default.
- W3136430911 cites W3045802278 @default.
- W3136430911 cites W3046061621 @default.
- W3136430911 cites W3046327795 @default.
- W3136430911 cites W3047095100 @default.
- W3136430911 cites W3080517202 @default.
- W3136430911 cites W3081536095 @default.
- W3136430911 cites W3082490235 @default.
- W3136430911 cites W3087103626 @default.
- W3136430911 cites W3091247468 @default.
- W3136430911 cites W3092982314 @default.
- W3136430911 cites W3096177766 @default.
- W3136430911 cites W3103598365 @default.