Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136451069> ?p ?o ?g. }
- W3136451069 endingPage "58" @default.
- W3136451069 startingPage "46" @default.
- W3136451069 abstract "Iron is highly regulated in the body, and a large part of this regulation is due to the peptide hepcidin. Dysregulation of iron homeostasis and high levels of hepcidin are observed in several chronic conditions, including anemia of CKD. Many commonly used diagnostic tests for assessing iron status may not accurately measure total body iron availability; therefore, more accurate and standardized methods of identifying iron deficiency in patients with CKD and inflammation should be pursued. The current standard of care for patients with anemia of CKD does not necessarily address this dysregulation of iron and in many cases can worsen the problem. Emerging therapies targeting other pathways (such as HIF-PH inhibitors, which allow for increased activity of the HIF pathway) ameliorate anemia by increasing Hb levels and improving iron homeostasis by decreasing hepcidin levels, increasing iron absorption by upregulating duodenal cytochrome B and divalent metal transporter 1, and increasing iron transport by upregulating transferrin and transferrin receptor 1.122Kaplan J.M. Sharma N. Dikdan S. Hypoxia-inducible factor and its role in the management of anemia in chronic kidney disease.Int J Mol Sci. 2018; 19: E389Crossref PubMed Scopus (22) Google Scholar Hepcidin antagonists in development directly target hepcidin or components of its expression pathway to increase available iron. Great potential exists for newer therapies to address these challenges of the current treatment paradigm for anemia of CKD." @default.
- W3136451069 created "2021-03-29" @default.
- W3136451069 creator A5033721173 @default.
- W3136451069 date "2021-04-01" @default.
- W3136451069 modified "2023-10-11" @default.
- W3136451069 title "Iron metabolism and management: focus on chronic kidney disease" @default.
- W3136451069 cites W1571358690 @default.
- W3136451069 cites W1761222131 @default.
- W3136451069 cites W1970714562 @default.
- W3136451069 cites W1980042430 @default.
- W3136451069 cites W1984393349 @default.
- W3136451069 cites W1985099261 @default.
- W3136451069 cites W1987460376 @default.
- W3136451069 cites W2000924380 @default.
- W3136451069 cites W2002549547 @default.
- W3136451069 cites W2004652263 @default.
- W3136451069 cites W2005438156 @default.
- W3136451069 cites W2007679072 @default.
- W3136451069 cites W2007839859 @default.
- W3136451069 cites W2012956876 @default.
- W3136451069 cites W2019599941 @default.
- W3136451069 cites W2025063713 @default.
- W3136451069 cites W2026365609 @default.
- W3136451069 cites W2028420833 @default.
- W3136451069 cites W2031557560 @default.
- W3136451069 cites W2049912996 @default.
- W3136451069 cites W2050833520 @default.
- W3136451069 cites W2074224520 @default.
- W3136451069 cites W2074579161 @default.
- W3136451069 cites W2075054245 @default.
- W3136451069 cites W2076334423 @default.
- W3136451069 cites W2082958329 @default.
- W3136451069 cites W2085784457 @default.
- W3136451069 cites W2095160894 @default.
- W3136451069 cites W2098124630 @default.
- W3136451069 cites W2106855201 @default.
- W3136451069 cites W2109138011 @default.
- W3136451069 cites W2116374020 @default.
- W3136451069 cites W2116778406 @default.
- W3136451069 cites W2116854831 @default.
- W3136451069 cites W2116948290 @default.
- W3136451069 cites W2124116160 @default.
- W3136451069 cites W2126707535 @default.
- W3136451069 cites W2128599675 @default.
- W3136451069 cites W2128708293 @default.
- W3136451069 cites W2129185886 @default.
- W3136451069 cites W2130382251 @default.
- W3136451069 cites W2130613991 @default.
- W3136451069 cites W2136732413 @default.
- W3136451069 cites W2138609117 @default.
- W3136451069 cites W2146277667 @default.
- W3136451069 cites W2150878988 @default.
- W3136451069 cites W2151191790 @default.
- W3136451069 cites W2152348558 @default.
- W3136451069 cites W2166218331 @default.
- W3136451069 cites W2171628526 @default.
- W3136451069 cites W2178101235 @default.
- W3136451069 cites W2179358297 @default.
- W3136451069 cites W2206481924 @default.
- W3136451069 cites W2213017259 @default.
- W3136451069 cites W2222807855 @default.
- W3136451069 cites W2237988842 @default.
- W3136451069 cites W2268447664 @default.
- W3136451069 cites W2272875085 @default.
- W3136451069 cites W2339445416 @default.
- W3136451069 cites W2407889154 @default.
- W3136451069 cites W2419119266 @default.
- W3136451069 cites W2520158967 @default.
- W3136451069 cites W2562262017 @default.
- W3136451069 cites W2566193398 @default.
- W3136451069 cites W2599499085 @default.
- W3136451069 cites W2604904897 @default.
- W3136451069 cites W2606401822 @default.
- W3136451069 cites W2766330061 @default.
- W3136451069 cites W2772547249 @default.
- W3136451069 cites W2774371445 @default.
- W3136451069 cites W2790701104 @default.
- W3136451069 cites W2791043578 @default.
- W3136451069 cites W2791792946 @default.
- W3136451069 cites W2795990154 @default.
- W3136451069 cites W2799655697 @default.
- W3136451069 cites W2800908159 @default.
- W3136451069 cites W2801690820 @default.
- W3136451069 cites W2884202833 @default.
- W3136451069 cites W2887425495 @default.
- W3136451069 cites W2887645829 @default.
- W3136451069 cites W2895377702 @default.
- W3136451069 cites W2898498137 @default.
- W3136451069 cites W2903992936 @default.
- W3136451069 cites W2906938186 @default.
- W3136451069 cites W2913829274 @default.
- W3136451069 cites W2914891827 @default.
- W3136451069 cites W2915146394 @default.
- W3136451069 cites W2923217679 @default.
- W3136451069 cites W2940533351 @default.
- W3136451069 cites W2945654236 @default.
- W3136451069 cites W2946106947 @default.
- W3136451069 cites W2961921650 @default.