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- W3136452579 endingPage "2052.e21" @default.
- W3136452579 startingPage "2033" @default.
- W3136452579 abstract "Metastasis is the leading cause of cancer-related deaths, and greater knowledge of the metastatic microenvironment is necessary to effectively target this process. Microenvironmental changes occur at distant sites prior to clinically detectable metastatic disease; however, the key niche regulatory signals during metastatic progression remain poorly characterized. Here, we identify a core immune suppression gene signature in pre-metastatic niche formation that is expressed predominantly by myeloid cells. We target this immune suppression program by utilizing genetically engineered myeloid cells (GEMys) to deliver IL-12 to modulate the metastatic microenvironment. Our data demonstrate that IL12-GEMy treatment reverses immune suppression in the pre-metastatic niche by activating antigen presentation and T cell activation, resulting in reduced metastatic and primary tumor burden and improved survival of tumor-bearing mice. We demonstrate that IL12-GEMys can functionally modulate the core program of immune suppression in the pre-metastatic niche to successfully rebalance the dysregulated metastatic microenvironment in cancer." @default.
- W3136452579 created "2021-03-29" @default.
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- W3136452579 date "2021-04-01" @default.
- W3136452579 modified "2023-10-15" @default.
- W3136452579 title "Genetically engineered myeloid cells rebalance the core immune suppression program in metastasis" @default.
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