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- W3136453674 abstract "The constitutive production of nitric oxide (NO) by the different isoforms of the enzyme nitric oxide synthase (NOS) is a major factor in the regulation of cardiac function under physiological and pathological conditions alike. As such, it affects various manifestations of the process of myocardial aging in the postnatal period, including hypertrophy and fibrosis of the ventricles and their remodelling, impaired relaxation and decreased cardiac output. The aim of the present study was to establish whether a correlation exists between changes in the expression of neuronal NOS (nNOS) and the morphological characteristics of the myocardium during various periods of postnatal development. We used fifteen male Wistar rats, distributed in five age groups - 2 weeks old, 1 month old, 3 months old, 6 months old, and 12 months old, each group containing 3 animals. We used routine haematoxylin and eosin staining and specific immunohistochemical staining for nNOS. During the early postnatal period (1-3 months), we observed a normal histological appearance of the cardiomyocytes and the interstitial space. As aging progressed (6-12 months), we reported the presence of cardiomyocytic hypertrophy, with narrowing of the interstitial space, focal myocytolysis and pronounced accumulation of collagen fibres. The immunohistochemical staining for nNOS revealed that enzyme activity intensified over the course of postnatal development. It was distributed heterogeneously in the various layers of the myocardium and we noted differences in the enzyme expression between the left and the right ventricle. In conclusion, the increased expression of nNOS in senescent rats probably represents a protective mechanism against age-related hypertrophy of the cardiomyocytes. Further studies could possibly establish the importance of regional differences in enzyme expression within the myocardium." @default.
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- W3136453674 date "2017-10-10" @default.
- W3136453674 modified "2023-09-23" @default.
- W3136453674 title "A correlation between postnatal changes in the expression of nitric oxide synthase (NOS) in the rat myocardium and its morphological characteristics" @default.
- W3136453674 doi "https://doi.org/10.14748/ssm.v49i0.4817" @default.
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