Matches in SemOpenAlex for { <https://semopenalex.org/work/W313645809> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W313645809 abstract "Huntington's disease (HD) is a genetic neurodegenerative disorder with few available treatments. Clinical observations suggest prefrontal dysfunction in early stages of HD is associated with altered glutamate transport. Evidence from the R6/2 mouse model suggests an abnormal increase in glutamate signaling in the sensorimotor cortex and striatum.The present study was designed to determine if a similar deficit in glutamate function occurs in the prefrontal cortex (PFC) of Hdh(CAG150) mice.We used the following groups of 40 week old male and female Hdh(CAG150) mice: homozygote n = 7, heterozygote n = 7, wild type n = 6. Motor coordination was evaluated using a hanging wire grid test and a balance beam. Microdialysis measurements were taken from the PFC of freely moving mice while glutamate transporters were inhibited by L-trans-pyrrolidine-2, 4-dicarboxylate (PDC) and compared to baseline glutamate levels.RESULTS indicated an elevation in glutamate levels in response to PDC but no significant difference among genotype groups. When comparing wild type and homozygote alone, a significant difference in total extracellular glutamate was observed. Contrary to our original hypothesis, the homozygote group had lower glutamate levels compared to their wild type counterparts. Furthermore, there was a significant difference in GABA measurements across genotypes.Our results suggest a mechanistic dichotomy between R6/2 and Hdh(CAG150) mice and underscores the need to select the appropriate HD mouse model when assessing therapeutic interventions. In particular, the time when animals are evaluated can have a significant impact on behavioral and physiological measures and so should be carefully considered." @default.
- W313645809 created "2016-06-24" @default.
- W313645809 creator A5005497098 @default.
- W313645809 creator A5045725309 @default.
- W313645809 creator A5063845627 @default.
- W313645809 creator A5078047521 @default.
- W313645809 date "2014-01-01" @default.
- W313645809 modified "2023-09-24" @default.
- W313645809 title "Presymptomatic Glutamate Levels in Prefrontal Cortex in the Hdh(CAG150) Mouse Model of Huntington's Disease" @default.
- W313645809 cites W1573376105 @default.
- W313645809 cites W2002885460 @default.
- W313645809 cites W2017901987 @default.
- W313645809 cites W2042030103 @default.
- W313645809 cites W2052620246 @default.
- W313645809 cites W2096675020 @default.
- W313645809 cites W2135573968 @default.
- W313645809 cites W2136468386 @default.
- W313645809 cites W2143153920 @default.
- W313645809 cites W2167596663 @default.
- W313645809 cites W2316597145 @default.
- W313645809 doi "https://doi.org/10.3233/jhd-140114" @default.
- W313645809 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25575960" @default.
- W313645809 hasPublicationYear "2014" @default.
- W313645809 type Work @default.
- W313645809 sameAs 313645809 @default.
- W313645809 citedByCount "2" @default.
- W313645809 countsByYear W3136458092016 @default.
- W313645809 countsByYear W3136458092017 @default.
- W313645809 crossrefType "journal-article" @default.
- W313645809 hasAuthorship W313645809A5005497098 @default.
- W313645809 hasAuthorship W313645809A5045725309 @default.
- W313645809 hasAuthorship W313645809A5063845627 @default.
- W313645809 hasAuthorship W313645809A5078047521 @default.
- W313645809 hasConcept C104317684 @default.
- W313645809 hasConcept C126322002 @default.
- W313645809 hasConcept C134018914 @default.
- W313645809 hasConcept C135763542 @default.
- W313645809 hasConcept C153471976 @default.
- W313645809 hasConcept C15744967 @default.
- W313645809 hasConcept C169760540 @default.
- W313645809 hasConcept C169900460 @default.
- W313645809 hasConcept C170493617 @default.
- W313645809 hasConcept C2777348757 @default.
- W313645809 hasConcept C2779134260 @default.
- W313645809 hasConcept C2780062018 @default.
- W313645809 hasConcept C2780647506 @default.
- W313645809 hasConcept C2781195155 @default.
- W313645809 hasConcept C28406088 @default.
- W313645809 hasConcept C50156730 @default.
- W313645809 hasConcept C513476851 @default.
- W313645809 hasConcept C529278444 @default.
- W313645809 hasConcept C54355233 @default.
- W313645809 hasConcept C61174792 @default.
- W313645809 hasConcept C71924100 @default.
- W313645809 hasConcept C86803240 @default.
- W313645809 hasConceptScore W313645809C104317684 @default.
- W313645809 hasConceptScore W313645809C126322002 @default.
- W313645809 hasConceptScore W313645809C134018914 @default.
- W313645809 hasConceptScore W313645809C135763542 @default.
- W313645809 hasConceptScore W313645809C153471976 @default.
- W313645809 hasConceptScore W313645809C15744967 @default.
- W313645809 hasConceptScore W313645809C169760540 @default.
- W313645809 hasConceptScore W313645809C169900460 @default.
- W313645809 hasConceptScore W313645809C170493617 @default.
- W313645809 hasConceptScore W313645809C2777348757 @default.
- W313645809 hasConceptScore W313645809C2779134260 @default.
- W313645809 hasConceptScore W313645809C2780062018 @default.
- W313645809 hasConceptScore W313645809C2780647506 @default.
- W313645809 hasConceptScore W313645809C2781195155 @default.
- W313645809 hasConceptScore W313645809C28406088 @default.
- W313645809 hasConceptScore W313645809C50156730 @default.
- W313645809 hasConceptScore W313645809C513476851 @default.
- W313645809 hasConceptScore W313645809C529278444 @default.
- W313645809 hasConceptScore W313645809C54355233 @default.
- W313645809 hasConceptScore W313645809C61174792 @default.
- W313645809 hasConceptScore W313645809C71924100 @default.
- W313645809 hasConceptScore W313645809C86803240 @default.
- W313645809 hasLocation W3136458091 @default.
- W313645809 hasLocation W3136458092 @default.
- W313645809 hasOpenAccess W313645809 @default.
- W313645809 hasPrimaryLocation W3136458091 @default.
- W313645809 hasRelatedWork W1895086473 @default.
- W313645809 hasRelatedWork W2000109468 @default.
- W313645809 hasRelatedWork W2005441705 @default.
- W313645809 hasRelatedWork W2031256194 @default.
- W313645809 hasRelatedWork W2056846827 @default.
- W313645809 hasRelatedWork W2073617560 @default.
- W313645809 hasRelatedWork W2155626704 @default.
- W313645809 hasRelatedWork W2353284102 @default.
- W313645809 hasRelatedWork W313645809 @default.
- W313645809 hasRelatedWork W3146632740 @default.
- W313645809 isParatext "false" @default.
- W313645809 isRetracted "false" @default.
- W313645809 magId "313645809" @default.
- W313645809 workType "article" @default.