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• W3136458744 abstract "The extent of cross-protection provided by currently licensed bivalent and quadrivalent HPV vaccines versus direct protection against HPV 31-, 33-, 45-, 52-, and 58-related disease is debated. A systematic literature review was conducted to establish the duration and magnitude of cross-protection in interventional and observational studies. PubMed and Embase databases were searched to identify randomized controlled trials (RCT) and observational studies published between 2008 and 2019 reporting on efficacy and effectiveness of HPV vaccines in women against non-vaccine types 31, 33, 45, 52, 58, and 6 and 11 (non-bivalent types). Key outcomes of interest were vaccine efficacy against 6- and 12-month persistent infection or genital lesions, and type-specific genital HPV prevalence or incidence. RCT data were analyzed for the according-to-protocol (bivalent vaccine) or negative-for-14-HPV-types (quadrivalent vaccine) efficacy cohorts. Data from 23 RCTs and 33 observational studies evaluating cross-protection were extracted. RCTs assessed cross-protection in post-hoc analyses of small size subgroups. Among fully vaccinated, baseline HPV-naïve women, the bivalent vaccine showed statistically significant cross-protective efficacy, although with wide confidence intervals, against 6-month and 12-month persistent cervical infections and CIN2+ only consistently for HPV 31 and 45, with the highest effect observed for HPV 31 (range 64.6% [95% CI: 27.6 to 83.9] to 79.1% [97.7% CI: 27.6 to 95.9] for 6-month persistent infection; maximal follow-up 4.7 years). No cross-protection was shown in extended follow-up. The quadrivalent vaccine efficacy reached statistical significance for HPV 31 (46.2% [15.3–66.4]; follow-up: 3.6 years). Similarly, observational studies found consistently significant effectiveness only against HPV 31 and 45 with both vaccines. RCTs and observational studies show that cross-protection is inconsistent across non-vaccine HPV types and is largely driven by HPV 31 and 45. Furthermore, existing data suggest that it wanes over time; its long-term durability has not been established." @default.
• W3136458744 created "2021-03-29" @default.
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• W3136458744 date "2021-04-01" @default.
• W3136458744 modified "2023-10-10" @default.
• W3136458744 title "Systematic literature review of cross-protective effect of HPV vaccines based on data from randomized clinical trials and real-world evidence" @default.
• W3136458744 cites W1534129746 @default.
• W3136458744 cites W1561836836 @default.
• W3136458744 cites W1801376551 @default.
• W3136458744 cites W1874940430 @default.
• W3136458744 cites W1966185446 @default.
• W3136458744 cites W1991927723 @default.
• W3136458744 cites W1995164940 @default.
• W3136458744 cites W2024898833 @default.
• W3136458744 cites W2025347169 @default.
• W3136458744 cites W2025671366 @default.
• W3136458744 cites W2054454333 @default.
• W3136458744 cites W2067369819 @default.
• W3136458744 cites W2069143946 @default.
• W3136458744 cites W2077242619 @default.
• W3136458744 cites W2090149613 @default.
• W3136458744 cites W2095794160 @default.
• W3136458744 cites W2102786052 @default.
• W3136458744 cites W2103210722 @default.
• W3136458744 cites W2103720990 @default.
• W3136458744 cites W2103834380 @default.
• W3136458744 cites W2104065542 @default.
• W3136458744 cites W2109016129 @default.
• W3136458744 cites W2111071768 @default.
• W3136458744 cites W2116021620 @default.
• W3136458744 cites W2116827928 @default.
• W3136458744 cites W2123962939 @default.
• W3136458744 cites W2125054141 @default.
• W3136458744 cites W2133525827 @default.
• W3136458744 cites W2135671488 @default.
• W3136458744 cites W2152581536 @default.
• W3136458744 cites W2153692195 @default.
• W3136458744 cites W2165308280 @default.
• W3136458744 cites W2166678252 @default.
• W3136458744 cites W2167222579 @default.
• W3136458744 cites W2187298330 @default.
• W3136458744 cites W2272728195 @default.
• W3136458744 cites W2279505249 @default.
• W3136458744 cites W2345048633 @default.
• W3136458744 cites W2413163782 @default.
• W3136458744 cites W2467415850 @default.
• W3136458744 cites W2512277165 @default.
• W3136458744 cites W2527846927 @default.
• W3136458744 cites W2555279693 @default.
• W3136458744 cites W2565679659 @default.
• W3136458744 cites W2569638620 @default.
• W3136458744 cites W2581529398 @default.
• W3136458744 cites W2613698041 @default.
• W3136458744 cites W2747684038 @default.
• W3136458744 cites W2752368216 @default.
• W3136458744 cites W2756593314 @default.
• W3136458744 cites W2757094995 @default.
• W3136458744 cites W2757798274 @default.
• W3136458744 cites W2765372369 @default.
• W3136458744 cites W2767146116 @default.
• W3136458744 cites W2784034238 @default.
• W3136458744 cites W2784272328 @default.
• W3136458744 cites W2789410260 @default.
• W3136458744 cites W2790356598 @default.
• W3136458744 cites W2791010220 @default.
• W3136458744 cites W2793560060 @default.
• W3136458744 cites W2794331082 @default.
• W3136458744 cites W2800123898 @default.
• W3136458744 cites W2800236160 @default.
• W3136458744 cites W2803116550 @default.
• W3136458744 cites W2807189671 @default.
• W3136458744 cites W2808329681 @default.
• W3136458744 cites W2883630502 @default.
• W3136458744 cites W2887003101 @default.
• W3136458744 cites W2897922922 @default.
• W3136458744 cites W2909193686 @default.
• W3136458744 cites W2912706936 @default.
• W3136458744 cites W2914202961 @default.
• W3136458744 cites W2921270275 @default.
• W3136458744 cites W2924701354 @default.
• W3136458744 cites W2929070495 @default.
• W3136458744 cites W2947121337 @default.
• W3136458744 cites W2948194883 @default.
• W3136458744 cites W2961523598 @default.
• W3136458744 cites W2967702593 @default.
• W3136458744 cites W2971674937 @default.
• W3136458744 cites W2986111000 @default.
• W3136458744 cites W2993186235 @default.

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