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• W3136459518 abstract "ABSTRACT Osteogenesis imperfecta (OI) is an inheritable, genetic, and collagen‐related disorder leading to an increase in bone fragility, but the origin of its “brittle behavior” is unclear. Because of its complex hierarchical structure, bone behaves differently at various length scales. This study aims to compare mechanical properties of human OI bone with healthy control bone at the extracellular matrix (ECM) level and to quantify the influence of the degree of mineralization. Degree of mineralization and mechanical properties were analyzed under dry conditions in 12 fixed and embedded transiliac crest biopsies (control n = 6, OI type I n = 3, OI type IV n = 2, and OI type III n = 1). Mean degree of mineralization was measured by microcomputed tomography at the biopsy level and the mineral‐to‐matrix ratio was assessed by Raman spectroscopy at the ECM level. Both methods revealed that the degree of mineralization is higher for OI bone compared with healthy control. Micropillar compression is a novel technique for quantifying post‐yield properties of bone at the ECM level. Micropillars (d = 5 μm, h = 10 μm) were fabricated using focused ion beam milling and quasi‐statically compressed to capture key post‐yield properties such as ultimate strength. The qualitative inspection of the stress–strain curves showed that both OI and healthy control bone have a ductile response at the ECM level. The quantitative results showed that compressive strength is not reduced in OI bone and is increasing with OI severity. Nanoindentation measurements revealed that OI bone tends to have a higher Young's modulus, hardness, and dissipated energy compared with healthy bone. Micropillar strength and indentation modulus increased linearly and significantly ( p < .0001) with mineral‐to‐matrix ratio. In conclusion, this study indicates that compressive mechanical properties of dry OI bone at the iliac crest are not inferior to healthy control at the ECM level and increase with mineralization. © 2021 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR)." @default.
• W3136459518 created "2021-03-29" @default.
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• W3136459518 date "2021-04-04" @default.
• W3136459518 modified "2023-10-14" @default.
• W3136459518 title "Compressive Strength of Iliac Bone <scp>ECM</scp> Is Not Reduced in Osteogenesis Imperfecta and Increases With Mineralization" @default.
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• W3136459518 doi "https://doi.org/10.1002/jbmr.4286" @default.
• W3136459518 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8359849" @default.
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