Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136491112> ?p ?o ?g. }
- W3136491112 endingPage "120497" @default.
- W3136491112 startingPage "120497" @default.
- W3136491112 abstract "Abstract ACE inhibitors or angiotensin II receptor blockers (ACEi/ARBs) have been a cornerstone of the management in kidney disease, but their use is often limited by undesired systemic effects, such as symptomatic hypotension. To minimize the extra-renal effects of ACEi/ARBs, we formulated hydrophobically modified glycol chitosan (HGC) nanomicelles releasing olmesartan (HGC-Olm) that specifically accumulated in the kidney, and investigated whether kidney-specific delivery of olmesartan by HGC nanomicelles could ameliorate organ damage in Col4a3−/− mouse, a murine model of progressive chronic kidney disease mimicking human Alport syndrome. Ex vivo tracing demonstrated that intravenously injected HGC-Olm nanomicelles were specifically delivered to the kidney, with sustained release of olmesartan for more than 48 h. Contrary to the conventional delivery of olmesartan via oral route, injection of HGC-Olm nanomicelles did not alter blood pressure in Col4a3−/− mice. Immunohistochemistry revealed that HGC nanomicelles were diffusely distributed from the cortex and glomeruli to the outer medulla, sparing the inner medulla. Phenotypic analysis showed that the attenuation of kidney fibrosis in the kidney of Col4a3−/− mice by HGC-Olm nanomicelles was comparable to that noted with conventionally delivered olmesartan. Therefore, our results suggest that HGC-Olm nanomicelles could be a safe and effective alternative drug delivery system for kidney diseases." @default.
- W3136491112 created "2021-03-29" @default.
- W3136491112 creator A5044585468 @default.
- W3136491112 creator A5049703409 @default.
- W3136491112 creator A5053995401 @default.
- W3136491112 creator A5054051087 @default.
- W3136491112 creator A5054887428 @default.
- W3136491112 creator A5066474772 @default.
- W3136491112 creator A5069956472 @default.
- W3136491112 creator A5073490663 @default.
- W3136491112 creator A5083654890 @default.
- W3136491112 creator A5084101824 @default.
- W3136491112 date "2021-05-01" @default.
- W3136491112 modified "2023-10-17" @default.
- W3136491112 title "Kidney-accumulating olmesartan-loaded nanomicelles ameliorate the organ damage in a murine model of Alport syndrome" @default.
- W3136491112 cites W1970068637 @default.
- W3136491112 cites W1982633631 @default.
- W3136491112 cites W1985456920 @default.
- W3136491112 cites W1997666142 @default.
- W3136491112 cites W1997832988 @default.
- W3136491112 cites W2000040025 @default.
- W3136491112 cites W2004819111 @default.
- W3136491112 cites W2008100303 @default.
- W3136491112 cites W2010444753 @default.
- W3136491112 cites W2018237806 @default.
- W3136491112 cites W2043757786 @default.
- W3136491112 cites W2044773944 @default.
- W3136491112 cites W2047882967 @default.
- W3136491112 cites W2049030581 @default.
- W3136491112 cites W2054902365 @default.
- W3136491112 cites W2056976690 @default.
- W3136491112 cites W2093178436 @default.
- W3136491112 cites W2117137750 @default.
- W3136491112 cites W2117892119 @default.
- W3136491112 cites W2119619243 @default.
- W3136491112 cites W2124964208 @default.
- W3136491112 cites W2127923616 @default.
- W3136491112 cites W2132637517 @default.
- W3136491112 cites W2134382817 @default.
- W3136491112 cites W2135369903 @default.
- W3136491112 cites W2149146712 @default.
- W3136491112 cites W2163782177 @default.
- W3136491112 cites W2169506520 @default.
- W3136491112 cites W2214635236 @default.
- W3136491112 cites W2507393168 @default.
- W3136491112 cites W2552554514 @default.
- W3136491112 cites W2556027368 @default.
- W3136491112 cites W2594226479 @default.
- W3136491112 cites W2615684303 @default.
- W3136491112 cites W2807471721 @default.
- W3136491112 cites W2916155839 @default.
- W3136491112 cites W2917676741 @default.
- W3136491112 cites W2965950376 @default.
- W3136491112 cites W2999032424 @default.
- W3136491112 cites W3008399112 @default.
- W3136491112 cites W3013344777 @default.
- W3136491112 cites W3016881059 @default.
- W3136491112 cites W3021001201 @default.
- W3136491112 cites W3080117107 @default.
- W3136491112 doi "https://doi.org/10.1016/j.ijpharm.2021.120497" @default.
- W3136491112 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33753165" @default.
- W3136491112 hasPublicationYear "2021" @default.
- W3136491112 type Work @default.
- W3136491112 sameAs 3136491112 @default.
- W3136491112 citedByCount "3" @default.
- W3136491112 countsByYear W31364911122021 @default.
- W3136491112 countsByYear W31364911122023 @default.
- W3136491112 crossrefType "journal-article" @default.
- W3136491112 hasAuthorship W3136491112A5044585468 @default.
- W3136491112 hasAuthorship W3136491112A5049703409 @default.
- W3136491112 hasAuthorship W3136491112A5053995401 @default.
- W3136491112 hasAuthorship W3136491112A5054051087 @default.
- W3136491112 hasAuthorship W3136491112A5054887428 @default.
- W3136491112 hasAuthorship W3136491112A5066474772 @default.
- W3136491112 hasAuthorship W3136491112A5069956472 @default.
- W3136491112 hasAuthorship W3136491112A5073490663 @default.
- W3136491112 hasAuthorship W3136491112A5083654890 @default.
- W3136491112 hasAuthorship W3136491112A5084101824 @default.
- W3136491112 hasConcept C126322002 @default.
- W3136491112 hasConcept C185592680 @default.
- W3136491112 hasConcept C2776908417 @default.
- W3136491112 hasConcept C2779766728 @default.
- W3136491112 hasConcept C2780091579 @default.
- W3136491112 hasConcept C2780368995 @default.
- W3136491112 hasConcept C71924100 @default.
- W3136491112 hasConcept C84393581 @default.
- W3136491112 hasConcept C98274493 @default.
- W3136491112 hasConceptScore W3136491112C126322002 @default.
- W3136491112 hasConceptScore W3136491112C185592680 @default.
- W3136491112 hasConceptScore W3136491112C2776908417 @default.
- W3136491112 hasConceptScore W3136491112C2779766728 @default.
- W3136491112 hasConceptScore W3136491112C2780091579 @default.
- W3136491112 hasConceptScore W3136491112C2780368995 @default.
- W3136491112 hasConceptScore W3136491112C71924100 @default.
- W3136491112 hasConceptScore W3136491112C84393581 @default.
- W3136491112 hasConceptScore W3136491112C98274493 @default.
- W3136491112 hasFunder F4320322120 @default.
- W3136491112 hasLocation W31364911121 @default.