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- W3136520009 endingPage "542" @default.
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- W3136520009 abstract "Melanoma is the most fatal form of skin cancer, with increasing prevalence worldwide. The most common melanoma genetic driver is mutation of the proto-oncogene serine/threonine kinase BRAF; thus, the inhibition of its MAP kinase pathway by specific inhibitors is a commonly applied therapy. However, many patients are resistant, or develop resistance to this type of monotherapy, and therefore combined therapies which target other signaling pathways through various molecular mechanisms are required. A possible strategy may involve targeting cellular energy metabolism, which has been recognized as crucial for cancer development and progression and which connects through glycolysis to cell surface glycan biosynthetic pathways. Protein glycosylation is a hallmark of more than 50% of the human proteome and it has been recognized that altered glycosylation occurs during the metastatic progression of melanoma cells which, in turn facilitates their migration. This review provides a description of recent advances in the search for factors able to remodel cell metabolism between glycolysis and oxidative phosphorylation, and of changes in specific markers and in the biophysical properties of cells during melanoma development from a nevus to metastasis. This development is accompanied by changes in the expression of surface glycans, with corresponding changes in ligand-receptor affinity, giving rise to structural features and viscoelastic parameters particularly well suited to study by label-free biophysical methods." @default.
- W3136520009 created "2021-03-29" @default.
- W3136520009 creator A5003256163 @default.
- W3136520009 creator A5011714668 @default.
- W3136520009 creator A5050226915 @default.
- W3136520009 creator A5050466657 @default.
- W3136520009 date "2021-03-17" @default.
- W3136520009 modified "2023-10-14" @default.
- W3136520009 title "Biophysical characterization of melanoma cell phenotype markers during metastatic progression" @default.
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