FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136545015> ?p ?o ?g. }

• W3136545015 endingPage "175883592110005" @default.
• W3136545015 startingPage "175883592110005" @default.
• W3136545015 abstract "There are conflicting data on the effects of dysbiosis-inducing drugs, and especially antibiotics (ATBs), on clinical outcomes in patients treated with immune checkpoint inhibitors (ICIs). There is a particular lack of data for patients with melanoma.We performed a single-center retrospective study of the associations between ATBs and other drugs known to modify the gut microbiota (proton pump inhibitors, nonsteroidal anti-inflammatory drugs, statins, opioids, anti-vitamin K, levothyroxine, vitamin D3, antiarrhythmics, metformin and phloroglucinol), overall survival (OS) and tumor response in consecutive cancer patients (particularly those with melanoma) treated with an ICI (ipilimumab, nivolumab or pembrolizumab) over a 9-year period.A total of 372 patients were included. The mean ± standard deviation age was 64.0 ± 12.1 years. The most frequently prescribed ICI was nivolumab (in 58.3% of patients) and the most frequent indications were lung cancer (44.6%) and melanoma (29.6%). Overall, 112 patients (30.1%) had received ATBs. ATB use was associated with (1) shorter OS in the study population as a whole [adjusted hazard ratio [95% confidence interval (CI)]: 1.38 (1.00-1.90), p = 0.048] and in patients with melanoma [adjusted hazard ratio (95% CI): 2.60 (1.06-6.39), p = 0.037], and (2) a lower response rate in the study population as a whole [8.1%, versus 31.1% in patients not treated with ATBs; adjusted odds ratio (95% CI): 6.06 (2.80-14.53), p < 0.001] and in patients with melanoma [adjusted odds ratio (95% CI): 4.41 (1.04-22.80), p = 0.045]. Sensitivity analyses that minimized the indication bias did not reveal an association between OS and the presence of an infection requiring ATBs (quantified as the severity of infection, hospitalization for an infection, or ICI discontinuation). Other dysbiosis-inducing drugs were not associated with a difference in OS.Unlike other dysbiosis-inducing drugs, ATBs were associated with poorer clinical outcomes in ICI-treated patients overall and in the subset of patients with melanoma." @default.
• W3136545015 created "2021-03-29" @default.
• W3136545015 creator A5002789402 @default.
• W3136545015 creator A5009411428 @default.
• W3136545015 creator A5018977565 @default.
• W3136545015 creator A5026549259 @default.
• W3136545015 creator A5033170314 @default.
• W3136545015 creator A5039964156 @default.
• W3136545015 creator A5044273026 @default.
• W3136545015 creator A5050799351 @default.
• W3136545015 creator A5056213263 @default.
• W3136545015 creator A5066647672 @default.
• W3136545015 creator A5084064178 @default.
• W3136545015 creator A5084151771 @default.
• W3136545015 date "2021-01-01" @default.
• W3136545015 modified "2023-10-17" @default.
• W3136545015 title "Associations between dysbiosis-inducing drugs, overall survival and tumor response in patients treated with immune checkpoint inhibitors" @default.
• W3136545015 cites W1541193052 @default.
• W3136545015 cites W1943350258 @default.
• W3136545015 cites W2000445173 @default.
• W3136545015 cites W2019607817 @default.
• W3136545015 cites W2051066741 @default.
• W3136545015 cites W2082158071 @default.
• W3136545015 cites W2087203965 @default.
• W3136545015 cites W2105057287 @default.
• W3136545015 cites W2123991085 @default.
• W3136545015 cites W2132916434 @default.
• W3136545015 cites W2144952279 @default.
• W3136545015 cites W2165456770 @default.
• W3136545015 cites W2179179825 @default.
• W3136545015 cites W2185075416 @default.
• W3136545015 cites W2194591433 @default.
• W3136545015 cites W2224656683 @default.
• W3136545015 cites W2518541854 @default.
• W3136545015 cites W2552593014 @default.
• W3136545015 cites W2563819218 @default.
• W3136545015 cites W2578528809 @default.
• W3136545015 cites W2617940752 @default.
• W3136545015 cites W2741790433 @default.
• W3136545015 cites W2741858880 @default.
• W3136545015 cites W2743031471 @default.
• W3136545015 cites W2747016053 @default.
• W3136545015 cites W2765314233 @default.
• W3136545015 cites W2773337546 @default.
• W3136545015 cites W2792021903 @default.
• W3136545015 cites W2794151342 @default.
• W3136545015 cites W2795186863 @default.
• W3136545015 cites W2795291772 @default.
• W3136545015 cites W2809351334 @default.
• W3136545015 cites W2888599070 @default.
• W3136545015 cites W2890466450 @default.
• W3136545015 cites W2905148438 @default.
• W3136545015 cites W2905314444 @default.
• W3136545015 cites W2906724057 @default.
• W3136545015 cites W2909988858 @default.
• W3136545015 cites W2917617290 @default.
• W3136545015 cites W2917765263 @default.
• W3136545015 cites W2919663648 @default.
• W3136545015 cites W2943781197 @default.
• W3136545015 cites W2946854701 @default.
• W3136545015 cites W2950297440 @default.
• W3136545015 cites W2952666958 @default.
• W3136545015 cites W2961510294 @default.
• W3136545015 cites W2981115487 @default.
• W3136545015 cites W2985762613 @default.
• W3136545015 cites W2988734364 @default.
• W3136545015 cites W2994922817 @default.
• W3136545015 cites W2995792867 @default.
• W3136545015 cites W2996819857 @default.
• W3136545015 cites W2997090158 @default.
• W3136545015 cites W3000170484 @default.
• W3136545015 cites W3000696551 @default.
• W3136545015 cites W3011269268 @default.
• W3136545015 cites W3030720988 @default.
• W3136545015 cites W3041885976 @default.
• W3136545015 cites W3086233380 @default.
• W3136545015 doi "https://doi.org/10.1177/17588359211000591" @default.
• W3136545015 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7968039" @default.
• W3136545015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33796151" @default.
• W3136545015 hasPublicationYear "2021" @default.
• W3136545015 type Work @default.
• W3136545015 sameAs 3136545015 @default.
• W3136545015 citedByCount "22" @default.
• W3136545015 countsByYear W31365450152021 @default.
• W3136545015 countsByYear W31365450152022 @default.
• W3136545015 countsByYear W31365450152023 @default.
• W3136545015 crossrefType "journal-article" @default.
• W3136545015 hasAuthorship W3136545015A5002789402 @default.
• W3136545015 hasAuthorship W3136545015A5009411428 @default.
• W3136545015 hasAuthorship W3136545015A5018977565 @default.
• W3136545015 hasAuthorship W3136545015A5026549259 @default.
• W3136545015 hasAuthorship W3136545015A5033170314 @default.
• W3136545015 hasAuthorship W3136545015A5039964156 @default.
• W3136545015 hasAuthorship W3136545015A5044273026 @default.
• W3136545015 hasAuthorship W3136545015A5050799351 @default.
• W3136545015 hasAuthorship W3136545015A5056213263 @default.
• W3136545015 hasAuthorship W3136545015A5066647672 @default.
• W3136545015 hasAuthorship W3136545015A5084064178 @default.

• next