Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136551086> ?p ?o ?g. }
- W3136551086 endingPage "168" @default.
- W3136551086 startingPage "168" @default.
- W3136551086 abstract "Nitrogen fixing-cyanobacteria can significantly improve the economic feasibility of cyanobacterial production processes by eliminating the requirement for reduced nitrogen. Anabaena sp. ATCC 33047 is a marine, heterocyst forming, nitrogen fixing cyanobacteria with a very short doubling time of 3.8 h. We developed a comprehensive genome-scale metabolic (GSM) model, iAnC892, for this organism using annotations and content obtained from multiple databases. iAnC892 describes both the vegetative and heterocyst cell types found in the filaments of Anabaena sp. ATCC 33047. iAnC892 includes 953 unique reactions and accounts for the annotation of 892 genes. Comparison of iAnC892 reaction content with the GSM of Anabaena sp. PCC 7120 revealed that there are 109 reactions including uptake hydrogenase, pyruvate decarboxylase, and pyruvate-formate lyase unique to iAnC892. iAnC892 enabled the analysis of energy production pathways in the heterocyst by allowing the cell specific deactivation of light dependent electron transport chain and glucose-6-phosphate metabolizing pathways. The analysis revealed the importance of light dependent electron transport in generating ATP and NADPH at the required ratio for optimal N2 fixation. When used alongside the strain design algorithm, OptForce, iAnC892 recapitulated several of the experimentally successful genetic intervention strategies that over produced valerolactam and caprolactam precursors." @default.
- W3136551086 created "2021-03-29" @default.
- W3136551086 creator A5021723671 @default.
- W3136551086 creator A5036831306 @default.
- W3136551086 creator A5038897284 @default.
- W3136551086 creator A5052394244 @default.
- W3136551086 creator A5063129452 @default.
- W3136551086 creator A5083411179 @default.
- W3136551086 creator A5083581014 @default.
- W3136551086 date "2021-03-15" @default.
- W3136551086 modified "2023-09-25" @default.
- W3136551086 title "A Genome-Scale Metabolic Model of Anabaena 33047 to Guide Genetic Modifications to Overproduce Nylon Monomers" @default.
- W3136551086 cites W1564684046 @default.
- W3136551086 cites W1566620022 @default.
- W3136551086 cites W1586958719 @default.
- W3136551086 cites W1665355332 @default.
- W3136551086 cites W1834384184 @default.
- W3136551086 cites W1844356324 @default.
- W3136551086 cites W1862616822 @default.
- W3136551086 cites W1874224989 @default.
- W3136551086 cites W1968193019 @default.
- W3136551086 cites W1977241851 @default.
- W3136551086 cites W1979287129 @default.
- W3136551086 cites W1987607959 @default.
- W3136551086 cites W1990500015 @default.
- W3136551086 cites W1992990770 @default.
- W3136551086 cites W2002071189 @default.
- W3136551086 cites W2003482855 @default.
- W3136551086 cites W2004548026 @default.
- W3136551086 cites W2004678533 @default.
- W3136551086 cites W2007368325 @default.
- W3136551086 cites W2012689220 @default.
- W3136551086 cites W2022446046 @default.
- W3136551086 cites W2023758892 @default.
- W3136551086 cites W2028823415 @default.
- W3136551086 cites W2032031593 @default.
- W3136551086 cites W2032239299 @default.
- W3136551086 cites W2034563987 @default.
- W3136551086 cites W2047265874 @default.
- W3136551086 cites W2057518669 @default.
- W3136551086 cites W2065438615 @default.
- W3136551086 cites W2065888407 @default.
- W3136551086 cites W2069824398 @default.
- W3136551086 cites W2070135088 @default.
- W3136551086 cites W2076262841 @default.
- W3136551086 cites W2078355959 @default.
- W3136551086 cites W2089745750 @default.
- W3136551086 cites W2096118044 @default.
- W3136551086 cites W2100084634 @default.
- W3136551086 cites W2100748186 @default.
- W3136551086 cites W2101392259 @default.
- W3136551086 cites W2101715504 @default.
- W3136551086 cites W2102363627 @default.
- W3136551086 cites W2116053228 @default.
- W3136551086 cites W2142237411 @default.
- W3136551086 cites W2142696945 @default.
- W3136551086 cites W2147582359 @default.
- W3136551086 cites W2151845226 @default.
- W3136551086 cites W2156663310 @default.
- W3136551086 cites W2157933969 @default.
- W3136551086 cites W2196234678 @default.
- W3136551086 cites W2509796664 @default.
- W3136551086 cites W2517936649 @default.
- W3136551086 cites W2527761550 @default.
- W3136551086 cites W2545439160 @default.
- W3136551086 cites W2558877759 @default.
- W3136551086 cites W2605013004 @default.
- W3136551086 cites W2606691171 @default.
- W3136551086 cites W2623611081 @default.
- W3136551086 cites W2761441559 @default.
- W3136551086 cites W2762019694 @default.
- W3136551086 cites W2795582507 @default.
- W3136551086 cites W2899765834 @default.
- W3136551086 cites W2914802824 @default.
- W3136551086 cites W2952117162 @default.
- W3136551086 cites W2995019602 @default.
- W3136551086 cites W3002525673 @default.
- W3136551086 cites W3003581587 @default.
- W3136551086 cites W3010629926 @default.
- W3136551086 cites W3031498566 @default.
- W3136551086 cites W4211239758 @default.
- W3136551086 cites W4231551535 @default.
- W3136551086 cites W48489920 @default.
- W3136551086 doi "https://doi.org/10.3390/metabo11030168" @default.
- W3136551086 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7999273" @default.
- W3136551086 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33804103" @default.
- W3136551086 hasPublicationYear "2021" @default.
- W3136551086 type Work @default.
- W3136551086 sameAs 3136551086 @default.
- W3136551086 citedByCount "2" @default.
- W3136551086 countsByYear W31365510862022 @default.
- W3136551086 crossrefType "journal-article" @default.
- W3136551086 hasAuthorship W3136551086A5021723671 @default.
- W3136551086 hasAuthorship W3136551086A5036831306 @default.
- W3136551086 hasAuthorship W3136551086A5038897284 @default.
- W3136551086 hasAuthorship W3136551086A5052394244 @default.
- W3136551086 hasAuthorship W3136551086A5063129452 @default.
- W3136551086 hasAuthorship W3136551086A5083411179 @default.