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- W3136555076 abstract "Endometrial cancer is the reason for rapid increases in mortality in women in economically developed countries and according to data in literature it`s incidence is 10 times higher than in undeveloped ones. There are a lots of variations in risk factors: age (around 60-70 years), physiological statement (premenopause, postmenopause, early menarche, late menopause, infertility, absence of pregnancy), obesity, estrogen hormone replacement therapy and reproductive factors. The risk of endometrial cancer is strongly influenced by obesity, but the mechanism of it`s action is still unknown. Adiposcytes produce various bioactive hormones - adipokines, the most prominent are leptin and adiponectin, that have relation with the mechanisms of action, so they play role in cancerogenous processes as cell proliferation, angiogenesis, influence the growth and proliferation of tumours. Aim of the study: Localization and role of adipokines in endometrium in women with diagnosed endometrial cancer. Маterial and Methods: The material was received from pathohistological biopsies of two women with diagnosed endometrial cancer. Classical immunohistological technique was applied. Results: Positive immune reaction was observed for both adiponectin and leptin in tumour cells, most stronger for leptin than adiponectin, probably because of the risk factor - obesity in one of the patients. Conclusions: Аdiponectin and leptin can be used as markers for possible risk of endometrial cancer." @default.
- W3136555076 created "2021-03-29" @default.
- W3136555076 creator A5037964187 @default.
- W3136555076 date "2016-01-01" @default.
- W3136555076 modified "2023-09-24" @default.
- W3136555076 title "Immunohistochemical study on localization of adipokines in endometrial cancer" @default.
- W3136555076 doi "https://doi.org/10.14748/ssm.v48i0.2355" @default.
- W3136555076 hasPublicationYear "2016" @default.
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