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• W3136555513 abstract "Over the last two decades, there have been a number of major landmark clinical trials, classified as major as they sought to address clear clinical practice driven questions, in a pragmatic yet robust trial design, using a large powered sample size (n > 1000), in order to help improve patient outcome through informing guidelines. A commonality across all stroke sub-types included in these trials is the tendency to acute hypertensive crises within the acute stroke period. This phenomenon is associated with greater stroke complications and worsened overall prognosis. Multiple trials have attempted to address the issue of acute blood pressure management during the acute stroke period, with consideration for timing, magnitude of lowering, agent and relationship to other interventions. This review will consider the major clinical trials performed in ischaemic and haemorrhagic stroke that test the hypothesis that acute BP reduction improves clinical outcomes." @default.
• W3136555513 created "2021-03-29" @default.
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• W3136555513 date "2021-03-24" @default.
• W3136555513 modified "2023-09-25" @default.
• W3136555513 title "Review of major trials of acute blood pressure management in stroke" @default.
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• W3136555513 doi "https://doi.org/10.1177/0271678x211004310" @default.
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