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- W3136557781 endingPage "2996" @default.
- W3136557781 startingPage "2996" @default.
- W3136557781 abstract "The endothelial glycocalyx, the gel layer covering the endothelium, is composed of glycosaminoglycans, proteoglycans, and adsorbed plasma proteins. This structure modulates vessels’ mechanotransduction, vascular permeability, and leukocyte adhesion. Thus, it regulates several physiological and pathological events. In the present review, we described the mechanisms that disturb glycocalyx stability such as reactive oxygen species, matrix metalloproteinases, and heparanase. We then focused our attention on the role of glycocalyx degradation in the induction of profibrotic events and on the possible pharmacological strategies to preserve this delicate structure." @default.
- W3136557781 created "2021-03-29" @default.
- W3136557781 creator A5024701804 @default.
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- W3136557781 creator A5043293851 @default.
- W3136557781 creator A5044135100 @default.
- W3136557781 creator A5065956126 @default.
- W3136557781 date "2021-03-15" @default.
- W3136557781 modified "2023-09-27" @default.
- W3136557781 title "Endothelial Glycocalyx as a Regulator of Fibrotic Processes" @default.
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