Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136571895> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W3136571895 abstract "AIM The present study aimed to explore whether 24 single nucleotide polymorphisms (SNPs) within the CACNA1C gene were associated with schizophrenia (SCZ) and antipsychotic response. METHODS A sample of 176 SCZ inpatients and 326 healthy controls of Korean ethnicity was collected for this purpose. Psychopathological status was evaluated at baseline and at discharge using the Positive and Negative Syndrome Scale (PANSS). RESULTS In the case-control study, rs1006737 (P=0.05) and rs2239104 (P=0.03) were associated with SCZ. Further, the rs10848635-rs1016388-rs1006737 haplotype was also associated with SCZ (P=0.03, simulate P=0.02). In the pharmacogenetic analyses, we did not find any association among the investigated SNPs and improvement in the PANSS total score. However, rs723672 and rs1034936 were associated with improvement in the PANSS positive subscale (respectively, P=0.02 and 0.05), rs2283271 in the negative subscale (P=0.01), rs10848635 and rs1016388 in the general subscale (respectively, P=0.03 and 0.04), and the rs3819536-rs2238062 haplotype (global statistics, P=0.1; simulate P=0.04). CONCLUSIONS Our findings further support a role for the CACNA1C gene, particularly for the rs1006737, in SCZ. Further, five SNPs were associated with improvement in PANSS subscales, suggesting a role for this gene in antipsychotic response as well. However, taking into account the limitations of the present study, further research is needed to confirm our findings." @default.
- W3136571895 created "2021-03-29" @default.
- W3136571895 creator A5006428625 @default.
- W3136571895 creator A5017929593 @default.
- W3136571895 creator A5034992280 @default.
- W3136571895 creator A5038381850 @default.
- W3136571895 creator A5067309981 @default.
- W3136571895 creator A5079520465 @default.
- W3136571895 date "2015-09-01" @default.
- W3136571895 modified "2023-09-23" @default.
- W3136571895 title "CACNA1C gene and schizophrenia: A case-control and pharmacogenetic study" @default.
- W3136571895 hasPublicationYear "2015" @default.
- W3136571895 type Work @default.
- W3136571895 sameAs 3136571895 @default.
- W3136571895 citedByCount "0" @default.
- W3136571895 crossrefType "journal-article" @default.
- W3136571895 hasAuthorship W3136571895A5006428625 @default.
- W3136571895 hasAuthorship W3136571895A5017929593 @default.
- W3136571895 hasAuthorship W3136571895A5034992280 @default.
- W3136571895 hasAuthorship W3136571895A5038381850 @default.
- W3136571895 hasAuthorship W3136571895A5067309981 @default.
- W3136571895 hasAuthorship W3136571895A5079520465 @default.
- W3136571895 hasConcept C104317684 @default.
- W3136571895 hasConcept C118552586 @default.
- W3136571895 hasConcept C123273963 @default.
- W3136571895 hasConcept C126322002 @default.
- W3136571895 hasConcept C135763542 @default.
- W3136571895 hasConcept C143998085 @default.
- W3136571895 hasConcept C153209595 @default.
- W3136571895 hasConcept C15744967 @default.
- W3136571895 hasConcept C180754005 @default.
- W3136571895 hasConcept C197754878 @default.
- W3136571895 hasConcept C2776412080 @default.
- W3136571895 hasConcept C2779727114 @default.
- W3136571895 hasConcept C2780135775 @default.
- W3136571895 hasConcept C2780494398 @default.
- W3136571895 hasConcept C54355233 @default.
- W3136571895 hasConcept C55775858 @default.
- W3136571895 hasConcept C70410870 @default.
- W3136571895 hasConcept C71924100 @default.
- W3136571895 hasConcept C86803240 @default.
- W3136571895 hasConceptScore W3136571895C104317684 @default.
- W3136571895 hasConceptScore W3136571895C118552586 @default.
- W3136571895 hasConceptScore W3136571895C123273963 @default.
- W3136571895 hasConceptScore W3136571895C126322002 @default.
- W3136571895 hasConceptScore W3136571895C135763542 @default.
- W3136571895 hasConceptScore W3136571895C143998085 @default.
- W3136571895 hasConceptScore W3136571895C153209595 @default.
- W3136571895 hasConceptScore W3136571895C15744967 @default.
- W3136571895 hasConceptScore W3136571895C180754005 @default.
- W3136571895 hasConceptScore W3136571895C197754878 @default.
- W3136571895 hasConceptScore W3136571895C2776412080 @default.
- W3136571895 hasConceptScore W3136571895C2779727114 @default.
- W3136571895 hasConceptScore W3136571895C2780135775 @default.
- W3136571895 hasConceptScore W3136571895C2780494398 @default.
- W3136571895 hasConceptScore W3136571895C54355233 @default.
- W3136571895 hasConceptScore W3136571895C55775858 @default.
- W3136571895 hasConceptScore W3136571895C70410870 @default.
- W3136571895 hasConceptScore W3136571895C71924100 @default.
- W3136571895 hasConceptScore W3136571895C86803240 @default.
- W3136571895 hasOpenAccess W3136571895 @default.
- W3136571895 hasRelatedWork W1986920358 @default.
- W3136571895 hasRelatedWork W1999200006 @default.
- W3136571895 hasRelatedWork W2008459275 @default.
- W3136571895 hasRelatedWork W2032173505 @default.
- W3136571895 hasRelatedWork W2039489018 @default.
- W3136571895 hasRelatedWork W2047284087 @default.
- W3136571895 hasRelatedWork W2057788905 @default.
- W3136571895 hasRelatedWork W2071130964 @default.
- W3136571895 hasRelatedWork W2181284849 @default.
- W3136571895 hasRelatedWork W2725787741 @default.
- W3136571895 hasRelatedWork W2909403953 @default.
- W3136571895 hasRelatedWork W2924114517 @default.
- W3136571895 hasRelatedWork W2947925821 @default.
- W3136571895 hasRelatedWork W2994747566 @default.
- W3136571895 hasRelatedWork W2996061605 @default.
- W3136571895 hasRelatedWork W3027525410 @default.
- W3136571895 hasRelatedWork W3030329096 @default.
- W3136571895 hasRelatedWork W3031267903 @default.
- W3136571895 hasRelatedWork W3169623238 @default.
- W3136571895 hasRelatedWork W583031275 @default.
- W3136571895 isParatext "false" @default.
- W3136571895 isRetracted "false" @default.
- W3136571895 magId "3136571895" @default.
- W3136571895 workType "article" @default.