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- W3136603676 abstract "More than two decades have elapsed since the publication of the first genome sequence of Mycobacterium tuberculosis ( Mtb ) which, shortly thereafter, enabled methods to determine gene essentiality in the pathogen. Despite this, target-based approaches have not yielded drugs that have progressed to clinical testing. Whole-cell screening followed by elucidation of mechanism of action has to date been the most fruitful approach to progressing inhibitors into the tuberculosis drug discovery pipeline although target-based approaches are gaining momentum. This review discusses scaffolds that have been identified over the last decade from screens of small molecule libraries against Mtb or defined targets where mechanism of action investigation has defined target-hit couples and structure-activity relationship studies have described the pharmacophore." @default.
- W3136603676 created "2021-03-29" @default.
- W3136603676 creator A5022838194 @default.
- W3136603676 creator A5039711964 @default.
- W3136603676 creator A5058976402 @default.
- W3136603676 creator A5071333745 @default.
- W3136603676 creator A5088592090 @default.
- W3136603676 date "2021-03-15" @default.
- W3136603676 modified "2023-10-18" @default.
- W3136603676 title "Tuberculosis Drug Discovery: A Decade of Hit Assessment for Defined Targets" @default.
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