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• W3136606681 abstract "Multidrug-resistant microorganisms are a well-known global problem, and gram-negative bacilli are top-ranking. When these pathogens are associated with bloodstream infections (BSI), outcomes become even worse. Here we applied whole-genome sequencing to access information about clonal distribution, resistance mechanism diversity and other molecular aspects of gram-negative bacilli (GNB) isolated from bloodstream infections in Brazil. It was possible to highlight international high-risk clones circulating in the Brazilian territory, such as CC258 for Klebsiella pneumoniae , ST79 for Acinetobacter baumannii and ST233 for Pseudomonas aeruginosa . Important associations can be made such as a negative correlation between CRISPR-Cas and K. pneumoniae CC258, while the genes bla TEM , bla KPC and bla CTX−M are highly associated with this clone. Specific relationships between A. baumannii clones and bla OXA−51 variants were also observed. All P. aeruginosa ST233 isolates showed the genes bla VIM and bla OXA486 . In addition, some trends could be identified, where a new P. aeruginosa MDR clone (ST3079), a novel A. baumannii clonal profile circulating in Brazil (ST848), and important resistance associations in the form of bla VIM−2 and bla IMP−56 being found together in one ST233 strain, stand out. Such findings may help to develop approaches to deal with BSI and even other nosocomial infections caused by these important GNB." @default.
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• W3136606681 date "2021-03-15" @default.
• W3136606681 modified "2023-09-29" @default.
• W3136606681 title "Genetic Basis of Antimicrobial Resistant Gram-Negative Bacteria Isolated From Bloodstream in Brazil" @default.
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• W3136606681 doi "https://doi.org/10.3389/fmed.2021.635206" @default.
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