FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136607621> ?p ?o ?g. }

• W3136607621 endingPage "4261" @default.
• W3136607621 startingPage "4251" @default.
• W3136607621 abstract "Rationale: The interaction between coagulation and inflammation resolution remains elusive. We recently highlighted a link between fibrinogen-like protein 2 (Fgl2) and a specialized pro-resolving mediator (SPM)-n-3 docosapentaenoic acid-derived resolvin D5 (RvD5n-3 DPA) in sepsis. This study aimed to investigate the functions of commonly used anticoagulants warfarin, dabigatran and heparin in regulating inflammation resolution.Methods: Peripheral blood was collected from clinical sepsis patients and healthy control for the determination of indicated indexes. Mouse sepsis models of zymosan-induced peritonitis and cecal ligation and puncture (CLP) were employed for the measurement of inflammation- and coagulation-related indexes. Western-blotting, ELISA and flow cytometry were applied to assess proteins. UPLC-MS/MS was used to evaluate lipid metabolites.Results: Here we report that the transmembrane Fgl2 (mFgl2) was positively associated with coagulation, while soluble Fgl2 (sFgl2) level correlated with the enhanced number of peripheral blood mononuclear cells in the sepsis patients. The anticoagulants dabigatran and warfarin attenuated zymosan-induced peritonitis, which was not shared by heparin, while only dabigatran significantly improved sepsis survival in the CLP sepsis mouse model. Although these anticoagulants consistently inhibited pro-inflammatory mediators including prostaglandin E2 and leukotriene B4, only dabigatran increased sFgl2 at both the initiation and resolution phases of inflammation. Mechanistically, dabigatran elicited the shedding of sFgl2 via prothrombin-related metalloproteases, thereby enhanced the subsequent biosynthesis of RvD5n-3 DPA via STAT6-ALOX15 axis. Blocking metalloproteases or ALOX15 significantly impaired dabigatran-enhanced macrophage efferocytosis in vitro, as well as delayed the dabigatran-accelerated inflammation resolution in vivo.Conclusions: Our findings identify the dual anti-inflammatory and pro-resolving actions of dabigatran, through promoting sFgl2-triggered RvD5n-3 DPA production, which has important implications for promoting tissue homeostasis of sepsis." @default.
• W3136607621 created "2021-03-29" @default.
• W3136607621 creator A5002318539 @default.
• W3136607621 creator A5003337858 @default.
• W3136607621 creator A5021122028 @default.
• W3136607621 creator A5023937997 @default.
• W3136607621 creator A5043484928 @default.
• W3136607621 creator A5044967169 @default.
• W3136607621 creator A5052486663 @default.
• W3136607621 creator A5052676364 @default.
• W3136607621 creator A5053730220 @default.
• W3136607621 creator A5056606902 @default.
• W3136607621 creator A5080756464 @default.
• W3136607621 creator A5091612515 @default.
• W3136607621 date "2021-01-01" @default.
• W3136607621 modified "2023-10-11" @default.
• W3136607621 title "Dabigatran activates inflammation resolution by promoting fibrinogen-like protein 2 shedding and RvD5_{n-3 DPA} production" @default.
• W3136607621 cites W1498644559 @default.
• W3136607621 cites W1518473002 @default.
• W3136607621 cites W1659248918 @default.
• W3136607621 cites W1924176543 @default.
• W3136607621 cites W1969162014 @default.
• W3136607621 cites W1971880637 @default.
• W3136607621 cites W1997439500 @default.
• W3136607621 cites W2010746507 @default.
• W3136607621 cites W2019243517 @default.
• W3136607621 cites W2039883000 @default.
• W3136607621 cites W2047425163 @default.
• W3136607621 cites W2049069390 @default.
• W3136607621 cites W2089957746 @default.
• W3136607621 cites W2090609282 @default.
• W3136607621 cites W2127986910 @default.
• W3136607621 cites W2201030059 @default.
• W3136607621 cites W2334118820 @default.
• W3136607621 cites W2337054068 @default.
• W3136607621 cites W2552137807 @default.
• W3136607621 cites W2606386439 @default.
• W3136607621 cites W2909149229 @default.
• W3136607621 cites W2957110380 @default.
• W3136607621 cites W2969471545 @default.
• W3136607621 cites W2980638427 @default.
• W3136607621 cites W2987551030 @default.
• W3136607621 cites W2994572080 @default.
• W3136607621 cites W3009322884 @default.
• W3136607621 cites W3024213168 @default.
• W3136607621 doi "https://doi.org/10.7150/thno.50182" @default.
• W3136607621 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7977467" @default.
• W3136607621 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33754059" @default.
• W3136607621 hasPublicationYear "2021" @default.
• W3136607621 type Work @default.
• W3136607621 sameAs 3136607621 @default.
• W3136607621 citedByCount "5" @default.
• W3136607621 countsByYear W31366076212022 @default.
• W3136607621 countsByYear W31366076212023 @default.
• W3136607621 crossrefType "journal-article" @default.
• W3136607621 hasAuthorship W3136607621A5002318539 @default.
• W3136607621 hasAuthorship W3136607621A5003337858 @default.
• W3136607621 hasAuthorship W3136607621A5021122028 @default.
• W3136607621 hasAuthorship W3136607621A5023937997 @default.
• W3136607621 hasAuthorship W3136607621A5043484928 @default.
• W3136607621 hasAuthorship W3136607621A5044967169 @default.
• W3136607621 hasAuthorship W3136607621A5052486663 @default.
• W3136607621 hasAuthorship W3136607621A5052676364 @default.
• W3136607621 hasAuthorship W3136607621A5053730220 @default.
• W3136607621 hasAuthorship W3136607621A5056606902 @default.
• W3136607621 hasAuthorship W3136607621A5080756464 @default.
• W3136607621 hasAuthorship W3136607621A5091612515 @default.
• W3136607621 hasBestOaLocation W31366076211 @default.
• W3136607621 hasConcept C126322002 @default.
• W3136607621 hasConcept C126838900 @default.
• W3136607621 hasConcept C185592680 @default.
• W3136607621 hasConcept C2776301958 @default.
• W3136607621 hasConcept C2776914184 @default.
• W3136607621 hasConcept C2778559731 @default.
• W3136607621 hasConcept C2778810321 @default.
• W3136607621 hasConcept C2779036427 @default.
• W3136607621 hasConcept C2779161974 @default.
• W3136607621 hasConcept C71924100 @default.
• W3136607621 hasConcept C98274493 @default.
• W3136607621 hasConceptScore W3136607621C126322002 @default.
• W3136607621 hasConceptScore W3136607621C126838900 @default.
• W3136607621 hasConceptScore W3136607621C185592680 @default.
• W3136607621 hasConceptScore W3136607621C2776301958 @default.
• W3136607621 hasConceptScore W3136607621C2776914184 @default.
• W3136607621 hasConceptScore W3136607621C2778559731 @default.
• W3136607621 hasConceptScore W3136607621C2778810321 @default.
• W3136607621 hasConceptScore W3136607621C2779036427 @default.
• W3136607621 hasConceptScore W3136607621C2779161974 @default.
• W3136607621 hasConceptScore W3136607621C71924100 @default.
• W3136607621 hasConceptScore W3136607621C98274493 @default.
• W3136607621 hasIssue "9" @default.
• W3136607621 hasLocation W31366076211 @default.
• W3136607621 hasLocation W31366076212 @default.
• W3136607621 hasOpenAccess W3136607621 @default.
• W3136607621 hasPrimaryLocation W31366076211 @default.
• W3136607621 hasRelatedWork W117746909 @default.
• W3136607621 hasRelatedWork W1905353571 @default.
• W3136607621 hasRelatedWork W2004315379 @default.

• next