FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136608968> ?p ?o ?g. }

• W3136608968 abstract "Abstract Cognitive impairment is common in multiple sclerosis (MS) and resting state functional MRI (rs-fMRI) functional connectivity (FC) is increasingly used to study its pathophysiology. However, results remain difficult to interpret, showing both high and low FC associated with cognitive impairment. We conducted a systematic review of rs-fMRI studies in MS to understand whether the direction of FC change relates to cognitive dysfunction, and how this may be influenced by the choice of methodology. Embase, Medline and PsycINFO were searched for studies assessing cognitive function and rs-fMRI FC in adults with MS. Fifty-seven studies were included in a narrative synthesis. Of these, 50 found an association between cognitive impairment and FC abnormalities. Worse cognition was linked to high FC in 18 studies, and to low FC in 17 studies. Nine studies found patterns of both high and low FC related to poor cognitive performance, in different regions or for different MR metrics. There was no clear link to increased FC during early stages of MS and reduced FC in later stages, as predicted by common models of MS pathology. Throughout, we found substantial heterogeneity in study methodology, and carefully consider how this may impact on the observed findings. These results indicate an urgent need for greater standardisation in the field – in the choice of MRI analysis and the definition of cognitive impairment. Through this we will be closer to using rs-fMRI FC as a biomarker in clinical studies, and as a tool to understand mechanisms underpinning cognitive symptoms in MS. Key points Cognitive impairment in multiple sclerosis (MS) is increasingly being researched with advanced magnetic resonance imaging (MRI) measures, including resting state functional MRI (rs-fMRI) The rs-fMRI functional connectivity (FC) metric is associated with cognitive impairment, and has the potential to be a biomarker of cognitive decline. A main challenge to developing a FC biomarker is the lack of consistency in the direction of FC changes associated with cognitive impairment, with cognitive deficits associated with both lower and higher FC. FC changes don’t appear to be linked to clinical and methodological factors such as disease phenotype, disease duration and brain region or network studied. Overall, there is substantial heterogeneity in study methodology, suggesting an acute need to standardise the study of cognitive impairment in MS and its investigation by rs-fMRI methods." @default.
• W3136608968 created "2021-03-29" @default.
• W3136608968 creator A5007092894 @default.
• W3136608968 creator A5007196021 @default.
• W3136608968 creator A5012943762 @default.
• W3136608968 creator A5015165446 @default.
• W3136608968 creator A5026516714 @default.
• W3136608968 creator A5039683609 @default.
• W3136608968 creator A5060851313 @default.
• W3136608968 creator A5074416256 @default.
• W3136608968 creator A5074938207 @default.
• W3136608968 date "2021-03-20" @default.
• W3136608968 modified "2023-10-16" @default.
• W3136608968 title "A systematic review of resting state functional MRI connectivity changes and cognitive impairment in multiple sclerosis" @default.
• W3136608968 cites W1491668984 @default.
• W3136608968 cites W1551155942 @default.
• W3136608968 cites W1825953317 @default.
• W3136608968 cites W1847168837 @default.
• W3136608968 cites W1936875239 @default.
• W3136608968 cites W1967091436 @default.
• W3136608968 cites W1969984092 @default.
• W3136608968 cites W1973897310 @default.
• W3136608968 cites W1976248796 @default.
• W3136608968 cites W1977453932 @default.
• W3136608968 cites W1977749401 @default.
• W3136608968 cites W1978047445 @default.
• W3136608968 cites W1979636244 @default.
• W3136608968 cites W1983182638 @default.
• W3136608968 cites W1988782420 @default.
• W3136608968 cites W1992977516 @default.
• W3136608968 cites W1996872488 @default.
• W3136608968 cites W2007607287 @default.
• W3136608968 cites W2017395555 @default.
• W3136608968 cites W2021061055 @default.
• W3136608968 cites W2024700864 @default.
• W3136608968 cites W2028734275 @default.
• W3136608968 cites W2031599446 @default.
• W3136608968 cites W2034597946 @default.
• W3136608968 cites W2041892844 @default.
• W3136608968 cites W2055425853 @default.
• W3136608968 cites W2069452291 @default.
• W3136608968 cites W2069949192 @default.
• W3136608968 cites W2070003162 @default.
• W3136608968 cites W2074785616 @default.
• W3136608968 cites W2085315487 @default.
• W3136608968 cites W2088976775 @default.
• W3136608968 cites W2095988501 @default.
• W3136608968 cites W2097547769 @default.
• W3136608968 cites W2098235800 @default.
• W3136608968 cites W2098923148 @default.
• W3136608968 cites W2106104226 @default.
• W3136608968 cites W2106654212 @default.
• W3136608968 cites W2108442841 @default.
• W3136608968 cites W2112852801 @default.
• W3136608968 cites W2114110854 @default.
• W3136608968 cites W2114643337 @default.
• W3136608968 cites W2114753322 @default.
• W3136608968 cites W2119360061 @default.
• W3136608968 cites W2120357670 @default.
• W3136608968 cites W2127070079 @default.
• W3136608968 cites W2127229016 @default.
• W3136608968 cites W2132603090 @default.
• W3136608968 cites W2135272309 @default.
• W3136608968 cites W2138394380 @default.
• W3136608968 cites W2144043115 @default.
• W3136608968 cites W2149973465 @default.
• W3136608968 cites W2150009720 @default.
• W3136608968 cites W2150378783 @default.
• W3136608968 cites W2150902492 @default.
• W3136608968 cites W2161374186 @default.
• W3136608968 cites W2163543209 @default.
• W3136608968 cites W2295940312 @default.
• W3136608968 cites W2326140696 @default.
• W3136608968 cites W2474011862 @default.
• W3136608968 cites W2485319663 @default.
• W3136608968 cites W2538235596 @default.
• W3136608968 cites W2553861531 @default.
• W3136608968 cites W2560393808 @default.
• W3136608968 cites W2560553695 @default.
• W3136608968 cites W2560588601 @default.
• W3136608968 cites W2565955889 @default.
• W3136608968 cites W2586359550 @default.
• W3136608968 cites W2588292672 @default.
• W3136608968 cites W2606989757 @default.
• W3136608968 cites W2611764076 @default.
• W3136608968 cites W2624142896 @default.
• W3136608968 cites W2753105249 @default.
• W3136608968 cites W2753428288 @default.
• W3136608968 cites W2764326159 @default.
• W3136608968 cites W2766388010 @default.
• W3136608968 cites W2771729549 @default.
• W3136608968 cites W2781645547 @default.
• W3136608968 cites W2783605273 @default.
• W3136608968 cites W2788106885 @default.
• W3136608968 cites W2792510705 @default.
• W3136608968 cites W2793926062 @default.
• W3136608968 cites W2802621302 @default.
• W3136608968 cites W2804378507 @default.
• W3136608968 cites W2804514583 @default.
• W3136608968 cites W2810021971 @default.

• next