FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136641892> ?p ?o ?g. }

• W3136641892 endingPage "e1009451" @default.
• W3136641892 startingPage "e1009451" @default.
• W3136641892 abstract "Salmonella enterica is a diverse bacterial pathogen and a primary cause of human and animal infections. While many S . enterica serovars present a broad host-specificity, several specialized pathotypes have been adapted to colonize and cause disease in one or limited numbers of host species. The underlying mechanisms defining Salmonella host-specificity are far from understood. Here, we present genetic analysis, phenotypic characterization and virulence profiling of a monophasic S . enterica serovar Typhimurium strain that was isolated from several wild sparrows in Israel. Whole genome sequencing and complete assembly of its genome demonstrate a unique genetic signature that includes the integration of the BTP1 prophage, loss of the virulence plasmid, pSLT and pseudogene accumulation in multiple T3SS-2 effectors ( sseJ , steC , gogB , sseK2 , and sseK3 ), catalase ( katE ), tetrathionate respiration ( ttrB ) and several adhesion/ colonization factors ( lpfD , fimH , bigA , ratB , siiC and siiE ) encoded genes. Correspondingly, this strain demonstrates impaired biofilm formation, intolerance to oxidative stress and compromised intracellular replication within non-phagocytic host cells. Moreover, while this strain showed attenuated pathogenicity in the mouse, it was highly virulent and caused an inflammatory disease in an avian host. Overall, our findings demonstrate a unique phenotypic profile and genetic makeup of an overlooked S . Typhimurium sparrow-associated lineage and present distinct genetic signatures that are likely to contribute to its pathoadaptation to passerine birds." @default.
• W3136641892 created "2021-03-29" @default.
• W3136641892 creator A5011188059 @default.
• W3136641892 creator A5017400327 @default.
• W3136641892 creator A5040755812 @default.
• W3136641892 creator A5047253113 @default.
• W3136641892 creator A5052122732 @default.
• W3136641892 creator A5054900639 @default.
• W3136641892 creator A5059210564 @default.
• W3136641892 creator A5061209530 @default.
• W3136641892 creator A5064099585 @default.
• W3136641892 creator A5066323112 @default.
• W3136641892 date "2021-03-19" @default.
• W3136641892 modified "2023-10-03" @default.
• W3136641892 title "Pathoadaptation of the passerine-associated Salmonella enterica serovar Typhimurium lineage to the avian host" @default.
• W3136641892 cites W1501985775 @default.
• W3136641892 cites W1519644081 @default.
• W3136641892 cites W1972800244 @default.
• W3136641892 cites W1975540898 @default.
• W3136641892 cites W1986261324 @default.
• W3136641892 cites W1991860284 @default.
• W3136641892 cites W2000483782 @default.
• W3136641892 cites W2002969627 @default.
• W3136641892 cites W2011067750 @default.
• W3136641892 cites W2012349645 @default.
• W3136641892 cites W2015213608 @default.
• W3136641892 cites W2020709171 @default.
• W3136641892 cites W2021242777 @default.
• W3136641892 cites W2036268678 @default.
• W3136641892 cites W2055862784 @default.
• W3136641892 cites W2058846600 @default.
• W3136641892 cites W2059220933 @default.
• W3136641892 cites W2066271947 @default.
• W3136641892 cites W2069702624 @default.
• W3136641892 cites W2071999738 @default.
• W3136641892 cites W2075944578 @default.
• W3136641892 cites W2079086122 @default.
• W3136641892 cites W2079748997 @default.
• W3136641892 cites W2080165516 @default.
• W3136641892 cites W2091030812 @default.
• W3136641892 cites W2091270609 @default.
• W3136641892 cites W2091901861 @default.
• W3136641892 cites W2096375646 @default.
• W3136641892 cites W2105537192 @default.
• W3136641892 cites W2114087442 @default.
• W3136641892 cites W2114853012 @default.
• W3136641892 cites W2116137883 @default.
• W3136641892 cites W2120818874 @default.
• W3136641892 cites W2122343132 @default.
• W3136641892 cites W2124920133 @default.
• W3136641892 cites W2132530250 @default.
• W3136641892 cites W2135146244 @default.
• W3136641892 cites W2135562678 @default.
• W3136641892 cites W2140341812 @default.
• W3136641892 cites W2153416750 @default.
• W3136641892 cites W2159700448 @default.
• W3136641892 cites W2160184764 @default.
• W3136641892 cites W2162758337 @default.
• W3136641892 cites W2167591869 @default.
• W3136641892 cites W2167730443 @default.
• W3136641892 cites W2228167218 @default.
• W3136641892 cites W2275251131 @default.
• W3136641892 cites W2290670224 @default.
• W3136641892 cites W2327892327 @default.
• W3136641892 cites W2345791363 @default.
• W3136641892 cites W2511727218 @default.
• W3136641892 cites W2742891955 @default.
• W3136641892 cites W2749937471 @default.
• W3136641892 cites W2758814752 @default.
• W3136641892 cites W2766330607 @default.
• W3136641892 cites W2768004481 @default.
• W3136641892 cites W2883992712 @default.
• W3136641892 cites W2903394252 @default.
• W3136641892 cites W2909486698 @default.
• W3136641892 cites W2911659876 @default.
• W3136641892 cites W2938099367 @default.
• W3136641892 cites W2939220580 @default.
• W3136641892 cites W2977241457 @default.
• W3136641892 cites W2993005136 @default.
• W3136641892 cites W3003680908 @default.
• W3136641892 cites W3034039479 @default.
• W3136641892 cites W3093512804 @default.
• W3136641892 cites W4232096031 @default.
• W3136641892 doi "https://doi.org/10.1371/journal.ppat.1009451" @default.
• W3136641892 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8011750" @default.
• W3136641892 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33739988" @default.
• W3136641892 hasPublicationYear "2021" @default.
• W3136641892 type Work @default.
• W3136641892 sameAs 3136641892 @default.
• W3136641892 citedByCount "18" @default.
• W3136641892 countsByYear W31366418922021 @default.
• W3136641892 countsByYear W31366418922022 @default.
• W3136641892 countsByYear W31366418922023 @default.
• W3136641892 crossrefType "journal-article" @default.
• W3136641892 hasAuthorship W3136641892A5011188059 @default.
• W3136641892 hasAuthorship W3136641892A5017400327 @default.
• W3136641892 hasAuthorship W3136641892A5040755812 @default.
• W3136641892 hasAuthorship W3136641892A5047253113 @default.

• next