FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136647608> ?p ?o ?g. }

• W3136647608 endingPage "5247" @default.
• W3136647608 startingPage "5233" @default.
• W3136647608 abstract "The constitutive activation of STAT3 through receptor tyrosine kinases triggered breast cancer cell growth and invasion-metastasis. Atiprimod impacts anti-proliferative, anti-carcinogenic effects in hepatocellular carcinoma, lymphoma, multiple myeloma via hindering the biological activity of STAT3. Dose-dependent atiprimod evokes first autophagy as a survival mechanism and then apoptosis due to prolonged ER stress in pituitary adenoma cells. The therapeutic efficiency and mechanistic action of atiprimod in breast cancer cells have not been investigated yet. Thus, we aimed to modulate the pivotal role of ER stress in atiprimod-triggered apoptosis in MDA-MB-231 and MDA-MB-468 breast cancer cells.Dose- and time-dependent atiprimod treatment inhibits cell viability and colony formation in MDA-MB-468 and MDA-MB-231 breast cancer cells. A moderate dose of atiprimod (2 μM) inhibited STAT3 phosphorylation at Tyr705 residue and also suppressed the total expression level of p65. In addition, nuclear localization of STAT1, 3, and NF-κB was prevented by atiprimod exposure in MDA-MB-231 and MDA-MB-468 cells. Atiprimod evokes PERK, BiP, ATF-4, CHOP upregulation, and PERK (Thr980), eIF2α (Ser51) phosphorylation's. However, atiprimod suppressed IRE1α-mediated Atg-3, 5, 7, 12 protein expressions and no alteration was observed on Beclin-1, p62 expression levels. PERK/eIF2α/ATF4/CHOP axis pivotal role in atiprimod-mediated G1/S arrest and apoptosis via Bak, Bax, Bim, and PUMA upregulation in MDA-MB-468 cells. Moreover, atiprimod renders MDA-MB-231 more vulnerable to type I programmed cell death by plasmid-mediated increased STAT3 expression.Atiprimod induced prolonged ER stress-mediated apoptosis via both activating PERK/eIF2α/ATF4/CHOP axis and suppressing STAT3/NF-κB transcription factors nuclear migration in TBNC cells." @default.
• W3136647608 created "2021-03-29" @default.
• W3136647608 creator A5003490576 @default.
• W3136647608 creator A5008044913 @default.
• W3136647608 creator A5032417976 @default.
• W3136647608 creator A5044461989 @default.
• W3136647608 creator A5089536528 @default.
• W3136647608 date "2021-06-01" @default.
• W3136647608 modified "2023-10-16" @default.
• W3136647608 title "Atiprimod triggered apoptotic cell death via acting on PERK/eIF2α/ATF4/CHOP and STAT3/NF-ΚB axis in MDA-MB-231 and MDA-MB-468 breast cancer cells" @default.
• W3136647608 cites W1968909827 @default.
• W3136647608 cites W1978949887 @default.
• W3136647608 cites W1986698508 @default.
• W3136647608 cites W1987388371 @default.
• W3136647608 cites W2012166934 @default.
• W3136647608 cites W2028350610 @default.
• W3136647608 cites W2042619042 @default.
• W3136647608 cites W2049159646 @default.
• W3136647608 cites W2051899176 @default.
• W3136647608 cites W2052414359 @default.
• W3136647608 cites W2066941321 @default.
• W3136647608 cites W2068648892 @default.
• W3136647608 cites W2071722450 @default.
• W3136647608 cites W2073574232 @default.
• W3136647608 cites W2074702359 @default.
• W3136647608 cites W2080901528 @default.
• W3136647608 cites W2085592353 @default.
• W3136647608 cites W2089400677 @default.
• W3136647608 cites W2099429776 @default.
• W3136647608 cites W2100608938 @default.
• W3136647608 cites W2116628300 @default.
• W3136647608 cites W2120736516 @default.
• W3136647608 cites W2137547634 @default.
• W3136647608 cites W2139517025 @default.
• W3136647608 cites W2159118796 @default.
• W3136647608 cites W2309472119 @default.
• W3136647608 cites W2402118151 @default.
• W3136647608 cites W2501536493 @default.
• W3136647608 cites W2580035316 @default.
• W3136647608 cites W2750307914 @default.
• W3136647608 cites W278457023 @default.
• W3136647608 cites W2788640168 @default.
• W3136647608 cites W2803445859 @default.
• W3136647608 cites W2806373800 @default.
• W3136647608 cites W2948633145 @default.
• W3136647608 cites W2956086379 @default.
• W3136647608 cites W2965326191 @default.
• W3136647608 cites W4251966084 @default.
• W3136647608 cites W908095114 @default.
• W3136647608 doi "https://doi.org/10.1007/s11033-021-06528-1" @default.
• W3136647608 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34244887" @default.
• W3136647608 hasPublicationYear "2021" @default.
• W3136647608 type Work @default.
• W3136647608 sameAs 3136647608 @default.
• W3136647608 citedByCount "7" @default.
• W3136647608 countsByYear W31366476082021 @default.
• W3136647608 countsByYear W31366476082022 @default.
• W3136647608 countsByYear W31366476082023 @default.
• W3136647608 crossrefType "journal-article" @default.
• W3136647608 hasAuthorship W3136647608A5003490576 @default.
• W3136647608 hasAuthorship W3136647608A5008044913 @default.
• W3136647608 hasAuthorship W3136647608A5032417976 @default.
• W3136647608 hasAuthorship W3136647608A5044461989 @default.
• W3136647608 hasAuthorship W3136647608A5089536528 @default.
• W3136647608 hasBestOaLocation W31366476082 @default.
• W3136647608 hasConcept C104317684 @default.
• W3136647608 hasConcept C127561419 @default.
• W3136647608 hasConcept C139447449 @default.
• W3136647608 hasConcept C185592680 @default.
• W3136647608 hasConcept C190283241 @default.
• W3136647608 hasConcept C2778923194 @default.
• W3136647608 hasConcept C31573885 @default.
• W3136647608 hasConcept C502942594 @default.
• W3136647608 hasConcept C53227056 @default.
• W3136647608 hasConcept C55493867 @default.
• W3136647608 hasConcept C86803240 @default.
• W3136647608 hasConceptScore W3136647608C104317684 @default.
• W3136647608 hasConceptScore W3136647608C127561419 @default.
• W3136647608 hasConceptScore W3136647608C139447449 @default.
• W3136647608 hasConceptScore W3136647608C185592680 @default.
• W3136647608 hasConceptScore W3136647608C190283241 @default.
• W3136647608 hasConceptScore W3136647608C2778923194 @default.
• W3136647608 hasConceptScore W3136647608C31573885 @default.
• W3136647608 hasConceptScore W3136647608C502942594 @default.
• W3136647608 hasConceptScore W3136647608C53227056 @default.
• W3136647608 hasConceptScore W3136647608C55493867 @default.
• W3136647608 hasConceptScore W3136647608C86803240 @default.
• W3136647608 hasIssue "6" @default.
• W3136647608 hasLocation W31366476081 @default.
• W3136647608 hasLocation W31366476082 @default.
• W3136647608 hasLocation W31366476083 @default.
• W3136647608 hasOpenAccess W3136647608 @default.
• W3136647608 hasPrimaryLocation W31366476081 @default.
• W3136647608 hasRelatedWork W2037596332 @default.
• W3136647608 hasRelatedWork W2059551362 @default.
• W3136647608 hasRelatedWork W2094538516 @default.
• W3136647608 hasRelatedWork W22134549 @default.
• W3136647608 hasRelatedWork W2306833291 @default.

• next