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• W3136648144 endingPage "1107" @default.
• W3136648144 startingPage "1097" @default.
• W3136648144 abstract "Aberrant expansion of the hexanucleotide GGGGCC (or G4C2) repeat in the human C9ORF72 gene is the most common genetic factor found behind amyotrophic lateral sclerosis and frontotemporal dementia. The hypothesized pathways, through which the repeat expansions contribute to the pathology, involve one or more secondary structural forms of the DNA and/or RNA sequences, such as G-quadruplexes, duplexes, and hairpins. Here, we study the structures of DNA and RNA duplexes formed by G4C2 repeats, which contain G(syn)·G(anti) base pairs flanked by either G·C or C·G base pairs. We show that duplexes formed by G4C2 repeats contain alternately two types of G·G pair contexts exhibiting different syn–anti base flipping dynamics (∼100 ms vs ∼2 ms for DNA and ∼50 ms vs ∼20 ms for RNA at 10 °C, respectively) depending on the flanking bases, with the slow-flipping G·G pairs being flanked by a guanine at the 5′-end and the fast-flipping G·G pairs being flanked by a cytosine at the 5′-end. Our findings on the structures and dynamics of G·G base pairs in DNA and RNA duplexes formed by G4C2 repeats provide a foundation for further studies of the functions and targeting of such biologically relevant motifs." @default.
• W3136648144 created "2021-03-29" @default.
• W3136648144 creator A5010553710 @default.
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• W3136648144 creator A5065213875 @default.
• W3136648144 creator A5072615123 @default.
• W3136648144 date "2021-03-22" @default.
• W3136648144 modified "2023-09-26" @default.
• W3136648144 title "Duplexes Formed by G₄C₂ Repeats Contain Alternate Slow- and Fast-Flipping G·G Base Pairs" @default.
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• W3136648144 doi "https://doi.org/10.1021/acs.biochem.0c00916" @default.
• W3136648144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33750098" @default.
• W3136648144 hasPublicationYear "2021" @default.
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