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• W3136653265 endingPage "220" @default.
• W3136653265 startingPage "208" @default.
• W3136653265 abstract "Drug-induced liver injury (DILI), which refers to liver damage caused by a drug or its metabolites, has emerged as an important cause of acute liver failure (ALF) in recent years. Chemically-induced ALF in animal models mimics the pathology of DILI in humans; thus, these models are used to study the mechanism of potentially effective treatment strategies. Mesenchymal stromal cells (MSCs) possess immunomodulatory properties, and they alleviate acute liver injury and decrease the mortality of animals with chemically-induced ALF. Here, we summarize some of the existing research on the interaction between MSCs and immune cells, and discuss the possible mechanisms underlying the immuno-modulatory activity of MSCs in chemically-induced ALF. We conclude that MSCs can impact the phenotype and function of macrophages, as well as the differentiation and maturation of dendritic cells, and inhibit the proliferation and activation of T lymphocytes or B lymphocytes. MSCs also have immuno-modulatory effects on the production of cytokines, such as prostaglandin E2 and tumor necrosis factor-alpha-stimulated gene 6, in animal models. Thus, MSCs have significant benefits in the treatment of chemically-induced ALF by interacting with immune cells and they may be applied to DILI in humans in the near future." @default.
• W3136653265 created "2021-03-29" @default.
• W3136653265 creator A5007773038 @default.
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• W3136653265 creator A5084351619 @default.
• W3136653265 date "2021-03-26" @default.
• W3136653265 modified "2023-09-26" @default.
• W3136653265 title "Mesenchymal stromal cell-dependent immunoregulation in chemically-induced acute liver failure" @default.
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• W3136653265 doi "https://doi.org/10.4252/wjsc.v13.i3.208" @default.
• W3136653265 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8006015" @default.
• W3136653265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33815670" @default.
• W3136653265 hasPublicationYear "2021" @default.
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