FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136690469> ?p ?o ?g. }

• W3136690469 endingPage "1307" @default.
• W3136690469 startingPage "1299" @default.
• W3136690469 abstract "The recent AFFIRM-AHF trial assessing the effect of intravenous (IV) iron on outcomes in patients hospitalised with worsening heart failure who had iron deficiency (ID) narrowly missed its primary efficacy endpoint of recurrent hospitalisations for heart failure (HHF) or cardiovascular (CV) death. We conducted a meta-analysis to determine whether these results were consistent with previous trials.We searched for randomised trials of patients with heart failure investigating the effect of IV iron vs placebo/control groups that reported HHF and CV mortality from 1st January 2000 to 5th December 2020. Seven trials were identified and included in this analysis. A fixed effect model was applied to assess the effects of IV iron on the composite of first HHF or CV mortality and individual components of these.Altogether, 2,166 patients were included (n = 1168 assigned to IV iron; n = 998 assigned to control). IV iron reduced the composite of HHF or CV mortality substantially [OR 0.73; (95% confidence interval 0.59-0.90); p = 0.003]. Outcomes were consistent for the pooled trials prior to AFFIRM-AHF. Whereas first HHF were reduced substantially [OR 0.67; (0.54-0.85); p = 0.0007], the effect on CV mortality was uncertain but appeared smaller [OR 0.89; (0.66-1.21); p = 0.47].Administration of IV iron to patients with heart failure and ID reduces the risk of the composite outcome of first heart failure hospitalisation or cardiovascular mortality, but this outcome may be driven predominantly by an effect on HHF. At least three more substantial trials of intravenous iron are underway." @default.
• W3136690469 created "2021-03-29" @default.
• W3136690469 creator A5016095791 @default.
• W3136690469 creator A5017160240 @default.
• W3136690469 creator A5036013897 @default.
• W3136690469 creator A5042761326 @default.
• W3136690469 creator A5048218285 @default.
• W3136690469 creator A5055441634 @default.
• W3136690469 date "2021-03-23" @default.
• W3136690469 modified "2023-10-02" @default.
• W3136690469 title "Intravenous iron for heart failure with evidence of iron deficiency: a meta-analysis of randomised trials" @default.
• W3136690469 cites W162181629 @default.
• W3136690469 cites W1997355335 @default.
• W3136690469 cites W2002946832 @default.
• W3136690469 cites W2018650075 @default.
• W3136690469 cites W2028265881 @default.
• W3136690469 cites W2113083124 @default.
• W3136690469 cites W2113572732 @default.
• W3136690469 cites W2122817227 @default.
• W3136690469 cites W2139318112 @default.
• W3136690469 cites W2148669301 @default.
• W3136690469 cites W2153903059 @default.
• W3136690469 cites W2161383538 @default.
• W3136690469 cites W2165454367 @default.
• W3136690469 cites W2466082174 @default.
• W3136690469 cites W2609879055 @default.
• W3136690469 cites W2610645021 @default.
• W3136690469 cites W2614710189 @default.
• W3136690469 cites W2734960411 @default.
• W3136690469 cites W2761111693 @default.
• W3136690469 cites W2781931840 @default.
• W3136690469 cites W2786908448 @default.
• W3136690469 cites W2789583640 @default.
• W3136690469 cites W2809850559 @default.
• W3136690469 cites W2963195173 @default.
• W3136690469 cites W2978791123 @default.
• W3136690469 cites W3005659837 @default.
• W3136690469 cites W3106240111 @default.
• W3136690469 doi "https://doi.org/10.1007/s00392-021-01837-8" @default.
• W3136690469 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8318946" @default.
• W3136690469 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33755777" @default.
• W3136690469 hasPublicationYear "2021" @default.
• W3136690469 type Work @default.
• W3136690469 sameAs 3136690469 @default.
• W3136690469 citedByCount "35" @default.
• W3136690469 countsByYear W31366904692021 @default.
• W3136690469 countsByYear W31366904692022 @default.
• W3136690469 countsByYear W31366904692023 @default.
• W3136690469 crossrefType "journal-article" @default.
• W3136690469 hasAuthorship W3136690469A5016095791 @default.
• W3136690469 hasAuthorship W3136690469A5017160240 @default.
• W3136690469 hasAuthorship W3136690469A5036013897 @default.
• W3136690469 hasAuthorship W3136690469A5042761326 @default.
• W3136690469 hasAuthorship W3136690469A5048218285 @default.
• W3136690469 hasAuthorship W3136690469A5055441634 @default.
• W3136690469 hasBestOaLocation W31366904691 @default.
• W3136690469 hasConcept C126322002 @default.
• W3136690469 hasConcept C142724271 @default.
• W3136690469 hasConcept C164705383 @default.
• W3136690469 hasConcept C168563851 @default.
• W3136690469 hasConcept C203092338 @default.
• W3136690469 hasConcept C204787440 @default.
• W3136690469 hasConcept C27081682 @default.
• W3136690469 hasConcept C2777417653 @default.
• W3136690469 hasConcept C2778198053 @default.
• W3136690469 hasConcept C2778248108 @default.
• W3136690469 hasConcept C44249647 @default.
• W3136690469 hasConcept C71924100 @default.
• W3136690469 hasConcept C95190672 @default.
• W3136690469 hasConceptScore W3136690469C126322002 @default.
• W3136690469 hasConceptScore W3136690469C142724271 @default.
• W3136690469 hasConceptScore W3136690469C164705383 @default.
• W3136690469 hasConceptScore W3136690469C168563851 @default.
• W3136690469 hasConceptScore W3136690469C203092338 @default.
• W3136690469 hasConceptScore W3136690469C204787440 @default.
• W3136690469 hasConceptScore W3136690469C27081682 @default.
• W3136690469 hasConceptScore W3136690469C2777417653 @default.
• W3136690469 hasConceptScore W3136690469C2778198053 @default.
• W3136690469 hasConceptScore W3136690469C2778248108 @default.
• W3136690469 hasConceptScore W3136690469C44249647 @default.
• W3136690469 hasConceptScore W3136690469C71924100 @default.
• W3136690469 hasConceptScore W3136690469C95190672 @default.
• W3136690469 hasIssue "8" @default.
• W3136690469 hasLocation W31366904691 @default.
• W3136690469 hasLocation W31366904692 @default.
• W3136690469 hasLocation W31366904693 @default.
• W3136690469 hasLocation W31366904694 @default.
• W3136690469 hasOpenAccess W3136690469 @default.
• W3136690469 hasPrimaryLocation W31366904691 @default.
• W3136690469 hasRelatedWork W1894574165 @default.
• W3136690469 hasRelatedWork W1981859602 @default.
• W3136690469 hasRelatedWork W2094000083 @default.
• W3136690469 hasRelatedWork W2113811481 @default.
• W3136690469 hasRelatedWork W2125804349 @default.
• W3136690469 hasRelatedWork W2230641066 @default.
• W3136690469 hasRelatedWork W2531052508 @default.
• W3136690469 hasRelatedWork W2554756453 @default.
• W3136690469 hasRelatedWork W2765649467 @default.

• next