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• W3136702122 abstract "Abstract Splicing cascades that alter gene products post-transcriptionally also affect expression dynamics. We study a class of processes and associated distributions that emerge from a bursty promoter model coupled to a path graph of downstream mRNA splicing, and more generally examine the behavior of finite-activity jump drivers coupled to a directed acyclic graph of splicing with one or more roots. These solutions provide full time-dependent joint distributions for an arbitrary number of species, offering qualitative and quantitative insights about how splicing can regulate expression dynamics. Finally, we derive a set of quantitative constraints on the minimum complexity necessary to reproduce gene co-expression patterns using synchronized burst models. We validate these findings by analyzing long-read sequencing data, where we find evidence of expression patterns largely consistent with these constraints." @default.
• W3136702122 created "2021-03-29" @default.
• W3136702122 creator A5020008219 @default.
• W3136702122 creator A5041010223 @default.
• W3136702122 date "2021-03-24" @default.
• W3136702122 modified "2023-09-27" @default.
• W3136702122 title "Analytical solutions of the chemical master equation with bursty production and isomerization reactions" @default.
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• W3136702122 doi "https://doi.org/10.1101/2021.03.24.436847" @default.
• W3136702122 hasPublicationYear "2021" @default.
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