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• W3136704744 endingPage "127967" @default.
• W3136704744 startingPage "127967" @default.
• W3136704744 abstract "An ethanolic extract of Derris scandens flowers showed potent preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrient-deprived condition, with a PC50 value of 0.7 μg/mL. Phytochemical investigation of this active extract led to the isolation of four prenylated isoflavones (1–4) including a new compound named 4′-O-methylgrynullarin (1). The structure elucidation of the new compound was achieved by HRFABMS and NMR spectroscopic analysis. The isolated compounds exhibited potent anti-austerity activity against four different human pancreatic cancer cell lines under nutrient-deprived conditions. The new compound 4′-O-methylgrynullarin (1) was also found to inhibit PANC-1 cell migration and colony formation under nutrient-rich condition. Mechanistically, compound 1 inhibited key survival proteins in the Akt/mTOR signaling pathway. Therefore, 4′-O-methylgrynullarin (1) can be considered as a potential lead compound for the anticancer drug development based on the anti-austerity strategy." @default.
• W3136704744 created "2021-03-29" @default.
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• W3136704744 date "2021-05-01" @default.
• W3136704744 modified "2023-10-12" @default.
• W3136704744 title "A new anti-austerity agent, 4′-O-methylgrynullarin from Derris scandens induces PANC-1 human pancreatic cancer cell death under nutrition starvation via inhibition of Akt/mTOR pathway" @default.
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• W3136704744 doi "https://doi.org/10.1016/j.bmcl.2021.127967" @default.
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• W3136704744 hasPublicationYear "2021" @default.
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