FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136705142> ?p ?o ?g. }

• W3136705142 endingPage "1244" @default.
• W3136705142 startingPage "1236" @default.
• W3136705142 abstract "The 2016 WHO classifies IDH-mutant gliomas into oligodendroglioma or diffuse astrocytoma based on co-occurring genetic events. Recent literature addresses the concept of stratifying IDH-mutant gliomas based on prognostically significant molecular events. However, the presence of a second class-defining driver alteration in IDH-mutant gliomas has not been systematically described. We searched the sequencing database at our institutions as well as The Cancer Genome Atlas (TCGA) and cBioPortal for IDH-mutant gliomas with other potentially significant alterations. For each case, we reviewed the clinical information, histology and genetic profile. Of 1702 gliomas tested on our targeted exome sequencing panel, we identified 364 IDH-mutated gliomas, four of which had pathogenic FGFR alterations and one with BRAF V600E mutation. Five additional IDH-mutant gliomas with NTRK fusions were identified through collaboration with an outside institution. Also, a search in the glioma database in cBioPortal (5379 total glioma samples, 1515 cases [28.1%] with IDH1/2 mutation) revealed eight IDH-mutated gliomas with FGFR, NTRK or BRAF pathogenic alterations. All IDH-mutant gliomas with dual mutations identified were hemispheric and had a mean age at diagnosis of 36.2 years (range 16-55 years old). Co-occurring genetic events involved MYCN, RB and PTEN. Notable outcomes included a patient with an IDH1/FGFR1-mutated anaplastic oligodendroglioma who has survived 20 years after diagnosis. We describe a series of 18 IDH-mutant gliomas with co-occurring genetic events that have been described as independent class-defining drivers in other gliomas. While these tumors are rare and the significance of these alterations needs further exploration, alterations in FGFR, NTRK, and BRAF could have potential therapeutic implications and affect clinical trial design and results in IDH-mutant studies. Our data highlights that single gene testing for IDH1 in diffuse gliomas may be insufficient for detection of targets with potential important prognostic and treatment value." @default.
• W3136705142 created "2021-03-29" @default.
• W3136705142 creator A5004265135 @default.
• W3136705142 creator A5004402830 @default.
• W3136705142 creator A5010270402 @default.
• W3136705142 creator A5021656597 @default.
• W3136705142 creator A5022385078 @default.
• W3136705142 creator A5047837571 @default.
• W3136705142 creator A5049957915 @default.
• W3136705142 creator A5059965175 @default.
• W3136705142 creator A5066809288 @default.
• W3136705142 creator A5079599874 @default.
• W3136705142 creator A5086124836 @default.
• W3136705142 date "2021-07-01" @default.
• W3136705142 modified "2023-09-29" @default.
• W3136705142 title "IDH-mutant gliomas with additional class-defining molecular events" @default.
• W3136705142 cites W1492082915 @default.
• W3136705142 cites W1812256879 @default.
• W3136705142 cites W1970654034 @default.
• W3136705142 cites W1980767402 @default.
• W3136705142 cites W1982088425 @default.
• W3136705142 cites W1983493537 @default.
• W3136705142 cites W2005036868 @default.
• W3136705142 cites W2025238642 @default.
• W3136705142 cites W2028785929 @default.
• W3136705142 cites W2029995169 @default.
• W3136705142 cites W2035346960 @default.
• W3136705142 cites W2043380218 @default.
• W3136705142 cites W2062291041 @default.
• W3136705142 cites W2079688799 @default.
• W3136705142 cites W2107224559 @default.
• W3136705142 cites W2109816625 @default.
• W3136705142 cites W2115078134 @default.
• W3136705142 cites W2115276344 @default.
• W3136705142 cites W2127931233 @default.
• W3136705142 cites W2145489645 @default.
• W3136705142 cites W2146267855 @default.
• W3136705142 cites W2149441684 @default.
• W3136705142 cites W2158233796 @default.
• W3136705142 cites W2263206910 @default.
• W3136705142 cites W2263522623 @default.
• W3136705142 cites W2292803562 @default.
• W3136705142 cites W2474576644 @default.
• W3136705142 cites W2554921042 @default.
• W3136705142 cites W2586704604 @default.
• W3136705142 cites W2588735165 @default.
• W3136705142 cites W2594059953 @default.
• W3136705142 cites W2613362156 @default.
• W3136705142 cites W2618667624 @default.
• W3136705142 cites W2739147644 @default.
• W3136705142 cites W2802365177 @default.
• W3136705142 cites W2802818144 @default.
• W3136705142 cites W2929168862 @default.
• W3136705142 cites W2954309731 @default.
• W3136705142 cites W2974861223 @default.
• W3136705142 cites W2988468540 @default.
• W3136705142 cites W3001529224 @default.
• W3136705142 cites W3003863259 @default.
• W3136705142 cites W3007340395 @default.
• W3136705142 cites W3016756297 @default.
• W3136705142 cites W3017270631 @default.
• W3136705142 cites W3042369616 @default.
• W3136705142 doi "https://doi.org/10.1038/s41379-021-00795-w" @default.
• W3136705142 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33772213" @default.
• W3136705142 hasPublicationYear "2021" @default.
• W3136705142 type Work @default.
• W3136705142 sameAs 3136705142 @default.
• W3136705142 citedByCount "12" @default.
• W3136705142 countsByYear W31367051422022 @default.
• W3136705142 countsByYear W31367051422023 @default.
• W3136705142 crossrefType "journal-article" @default.
• W3136705142 hasAuthorship W3136705142A5004265135 @default.
• W3136705142 hasAuthorship W3136705142A5004402830 @default.
• W3136705142 hasAuthorship W3136705142A5010270402 @default.
• W3136705142 hasAuthorship W3136705142A5021656597 @default.
• W3136705142 hasAuthorship W3136705142A5022385078 @default.
• W3136705142 hasAuthorship W3136705142A5047837571 @default.
• W3136705142 hasAuthorship W3136705142A5049957915 @default.
• W3136705142 hasAuthorship W3136705142A5059965175 @default.
• W3136705142 hasAuthorship W3136705142A5066809288 @default.
• W3136705142 hasAuthorship W3136705142A5079599874 @default.
• W3136705142 hasAuthorship W3136705142A5086124836 @default.
• W3136705142 hasBestOaLocation W31367051421 @default.
• W3136705142 hasConcept C104317684 @default.
• W3136705142 hasConcept C127848430 @default.
• W3136705142 hasConcept C143065580 @default.
• W3136705142 hasConcept C16930146 @default.
• W3136705142 hasConcept C190283241 @default.
• W3136705142 hasConcept C2775922572 @default.
• W3136705142 hasConcept C2776059313 @default.
• W3136705142 hasConcept C2776689207 @default.
• W3136705142 hasConcept C2777609662 @default.
• W3136705142 hasConcept C2777931997 @default.
• W3136705142 hasConcept C2778227246 @default.
• W3136705142 hasConcept C2778880634 @default.
• W3136705142 hasConcept C2779083369 @default.
• W3136705142 hasConcept C37307934 @default.
• W3136705142 hasConcept C501734568 @default.

• next