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• W3136707825 abstract "Background: Sickle cell anaemia is the commonest haemoglobinopathy in pregnant Nigerian women, and cardiac manifestations are a significant feature of the disease especially in pregnancy. Pregnant women with sickle cell anaemia are at high risk of morbidity and mortality and cardiac dysfunction in them increases this risk and may compromise their post- partum health. Knowledge of optimal cardiac function during pregnancy as well as the post- partum period would help identify and promptly manage cardiac dysfunction in them when it occurs.Objective: The aim of this study was to assess and compare the cardiac function between pregnant women with HBSS and those with HBAA using echocardiography in LUTH.Study Design: A longitudinal comparative study.Study Area: Antenatal clinic, labour ward, and cardiovascular laboratory of LUTH.Methodology: A total of 40 women were recruited for the study, of which 20 pregnant HBSS were cases and 20 pregnant HBAA women were controls. Echocardiographic studies were performed in the third trimester of pregnancy. They were followed up till delivery, and a follow up Echocardiography was performed after 6 weeks post-partum. Paired t-test, student’s t-test and Pearson’s chi-square were used to respectively compare cardiovascular structure and function during the antepartum and post-partum state and between HBSS and HBAA participants.RESULTS: There was a statistically significant decrease in the mean left atrial diameter of HBSS women in the post-partum period compared to their antepartum state (3.89 ± 0.40 cm VS 4.31± 0.45cm (t= 4.218, P- value < 0.001). Similarly, there was a statistically significant decrease in the mean left ventricular diameter in systole of HBSS pregnant women in the post-partum period as compared to their antepartum state (3.36 ± 0.42cm VS 3.52 ± 0.41cmxi(t- 2.196, P- value- 0.041). In contrast, there was no statistically significant difference in the left atrial diameter in pregnant HBAA women in the antepartum period as compared to their post-partum state (3.69 ± 0.39cm VS 3.58 ± 0.41cm (t- 1.36, P-value- 0.189), but their left ventricular diameter in systole was also significantly higher than during the post-partum period (3.15 ± 0.39cm VS 3.01 ± 0.21cm (t- 2.16, P-value- 0.044). There was negative inverse correlation between haematocrit levels and cardiac size in pregnant HBSS women. Also, there were statistically significant differences in cardiac size but not function between the pregnant HBSS and pregnant HBAA women. (Left atrial diameter P-value- 0.001, left ventricular diameter in diastole P-value- 0.002, left ventricular diameter in systole P-value- 0.006. Ejection fraction P-value- 0.888, fractional shortening P-value- 0.532).CONCLUSION:It appears there are significant differences in some of the cardiac size dimensions in both pregnant HbSS women and pregnant HbAA women when comparing their antepartum and post-partum states. HbSS pregnant women also have significantly larger heart sizes than HbAA. However the cardiac left ventricular function did not seem to change both during pregnancy and in the post-partum period. Despite the larger cardiac size dimensions in pregnant HbSS women, they appear to cope during pregnancy in terms of cardiac function.RECOMMENDATIONS: Pregnant HbSS women can be reassured that their cardiac systolic function remains optimal during uncomplicated pregnancy. Further long term studies to evaluate cardiac changes at 6 months postpartum when cardiovascular changes in pregnancy have fully reversed may further validate these findings." @default.
• W3136707825 created "2021-03-29" @default.
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• W3136707825 date "2017-01-01" @default.
• W3136707825 modified "2023-09-24" @default.
• W3136707825 title "COMPARISON OF CARDIAC FUNCTION BETWEEN PREGNANT WOMEN WITH HBSS AND THOSE WITH HBAA USING ECHOCARDIOGRAPHY AT THE LAGOS UNIVERSITY TEACHING HOSPITAL, LAGOS, NIGERIA" @default.
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