Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136716043> ?p ?o ?g. }
- W3136716043 endingPage "117947" @default.
- W3136716043 startingPage "117947" @default.
- W3136716043 abstract "The linear anionic polysaccharide alginate (ALG) has been comprehensively studied for biomedical applications, yet thus far the in vivo fate of this polymer has not been explored in detail. The current study therefore evaluates the biodistribution of ultrapure ALG (M/G ratio ≥ 0.67 with a measured Mw of 530 kg/mol and polydispersity index; PDI of 1.49) over a 14-day period in BALB/c mice. The biodistribution pattern over 2-days after sample administration using PET imaging with 64Cu-labelled ALG showed liver and spleen uptake. This was confirmed by the 14-day biodistribution profile of cyanine 5-labelled ALG from in vivo and ex vivo fluorescence imaging. Using MacGreen mice confirmed the uptake of the ALG by macrophages in the spleen at the 2-day time point. This extended biodistribution study confirmed the clearance of only a portion of the administered ALG biopolymer, but also uptake by macrophage populations in the spleen over a 14-day period." @default.
- W3136716043 created "2021-03-29" @default.
- W3136716043 creator A5014665196 @default.
- W3136716043 creator A5049455451 @default.
- W3136716043 creator A5062728145 @default.
- W3136716043 creator A5078978680 @default.
- W3136716043 creator A5082337082 @default.
- W3136716043 date "2021-06-01" @default.
- W3136716043 modified "2023-10-06" @default.
- W3136716043 title "Evaluation of the in vivo fate of ultrapure alginate in a BALB/c mouse model" @default.
- W3136716043 cites W1498245652 @default.
- W3136716043 cites W1569313336 @default.
- W3136716043 cites W1593555249 @default.
- W3136716043 cites W1605964161 @default.
- W3136716043 cites W1758088127 @default.
- W3136716043 cites W1784006781 @default.
- W3136716043 cites W1909969017 @default.
- W3136716043 cites W1916800927 @default.
- W3136716043 cites W1964937485 @default.
- W3136716043 cites W1968925643 @default.
- W3136716043 cites W1969540651 @default.
- W3136716043 cites W1970489904 @default.
- W3136716043 cites W1971500643 @default.
- W3136716043 cites W1978654303 @default.
- W3136716043 cites W1980304686 @default.
- W3136716043 cites W1985914247 @default.
- W3136716043 cites W1988688069 @default.
- W3136716043 cites W1989014488 @default.
- W3136716043 cites W1991323391 @default.
- W3136716043 cites W1996241475 @default.
- W3136716043 cites W2010262551 @default.
- W3136716043 cites W2023767666 @default.
- W3136716043 cites W2026260621 @default.
- W3136716043 cites W2028088201 @default.
- W3136716043 cites W2030855909 @default.
- W3136716043 cites W2035883113 @default.
- W3136716043 cites W2039495834 @default.
- W3136716043 cites W2045053498 @default.
- W3136716043 cites W2054439940 @default.
- W3136716043 cites W2056791710 @default.
- W3136716043 cites W2058615010 @default.
- W3136716043 cites W2061089961 @default.
- W3136716043 cites W2061797584 @default.
- W3136716043 cites W2064999317 @default.
- W3136716043 cites W2065941395 @default.
- W3136716043 cites W2066050094 @default.
- W3136716043 cites W2066242829 @default.
- W3136716043 cites W2066957167 @default.
- W3136716043 cites W2074501348 @default.
- W3136716043 cites W2081202846 @default.
- W3136716043 cites W2085831434 @default.
- W3136716043 cites W2088003941 @default.
- W3136716043 cites W2101873325 @default.
- W3136716043 cites W2121664102 @default.
- W3136716043 cites W2122892857 @default.
- W3136716043 cites W2130755020 @default.
- W3136716043 cites W2137792756 @default.
- W3136716043 cites W2144312385 @default.
- W3136716043 cites W2146704352 @default.
- W3136716043 cites W2148145619 @default.
- W3136716043 cites W2287104519 @default.
- W3136716043 cites W2290877273 @default.
- W3136716043 cites W2302405003 @default.
- W3136716043 cites W2313482124 @default.
- W3136716043 cites W2318703804 @default.
- W3136716043 cites W2335924114 @default.
- W3136716043 cites W2337058518 @default.
- W3136716043 cites W2348348399 @default.
- W3136716043 cites W2399479416 @default.
- W3136716043 cites W2414338615 @default.
- W3136716043 cites W2544917882 @default.
- W3136716043 cites W2588784130 @default.
- W3136716043 cites W2889623068 @default.
- W3136716043 cites W2899407561 @default.
- W3136716043 cites W2900543464 @default.
- W3136716043 cites W2986770437 @default.
- W3136716043 cites W3023029213 @default.
- W3136716043 cites W3043135743 @default.
- W3136716043 cites W4236357753 @default.
- W3136716043 cites W769746831 @default.
- W3136716043 cites W966453984 @default.
- W3136716043 cites W968055600 @default.
- W3136716043 doi "https://doi.org/10.1016/j.carbpol.2021.117947" @default.
- W3136716043 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33838824" @default.
- W3136716043 hasPublicationYear "2021" @default.
- W3136716043 type Work @default.
- W3136716043 sameAs 3136716043 @default.
- W3136716043 citedByCount "2" @default.
- W3136716043 countsByYear W31367160432022 @default.
- W3136716043 countsByYear W31367160432023 @default.
- W3136716043 crossrefType "journal-article" @default.
- W3136716043 hasAuthorship W3136716043A5014665196 @default.
- W3136716043 hasAuthorship W3136716043A5049455451 @default.
- W3136716043 hasAuthorship W3136716043A5062728145 @default.
- W3136716043 hasAuthorship W3136716043A5078978680 @default.
- W3136716043 hasAuthorship W3136716043A5082337082 @default.
- W3136716043 hasConcept C150903083 @default.
- W3136716043 hasConcept C153911025 @default.