Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136743552> ?p ?o ?g. }
- W3136743552 abstract "SUMMARY The intestinal parasite, Cryptosporidium , is a major contributor to global child mortality and causes opportunistic infection in immune deficient individuals. Innate resistance to Cryptosporidium , which specifically invades enterocytes, is dependent on the production of IFN-γ, yet whether enterocytes contribute to parasite control is poorly understood. In this study, utilizing the natural mouse pathogen, Cryptosporidium tyzzeri , we show that epithelial-derived IL-18 synergized with IL-12 to stimulate innate lymphoid cell (ILC) production of IFN-γ. This innate IFN-γ was required for early parasite control. Loss of STAT1 in enterocytes, but not dendritic cells or macrophages, antagonized early parasite control. Transcriptional profiling of enterocytes from infected mice identified an IFN-γ signature and enrichment of anti-microbial effectors like IDO, GBP and IRG. Deletion experiments identified a role for Irgm1/m3 in parasite control. Thus, enterocytes promote ILC production of IFN-γ that acts on enterocytes to restrict the growth of C. tyzzeri ." @default.
- W3136743552 created "2021-03-29" @default.
- W3136743552 creator A5014242942 @default.
- W3136743552 creator A5015049795 @default.
- W3136743552 creator A5027185925 @default.
- W3136743552 creator A5031329520 @default.
- W3136743552 creator A5046491228 @default.
- W3136743552 creator A5055472723 @default.
- W3136743552 creator A5058415215 @default.
- W3136743552 creator A5061442255 @default.
- W3136743552 creator A5063845294 @default.
- W3136743552 creator A5064505579 @default.
- W3136743552 creator A5067493443 @default.
- W3136743552 creator A5079265883 @default.
- W3136743552 creator A5079825392 @default.
- W3136743552 date "2021-03-14" @default.
- W3136743552 modified "2023-10-01" @default.
- W3136743552 title "Crosstalk between enterocytes and innate lymphoid cell drives early IFN-γ-mediated control of <i>Cryptosporidium</i>" @default.
- W3136743552 cites W1608112211 @default.
- W3136743552 cites W1821981622 @default.
- W3136743552 cites W1962453948 @default.
- W3136743552 cites W1973723338 @default.
- W3136743552 cites W1988563171 @default.
- W3136743552 cites W1994516121 @default.
- W3136743552 cites W2004413953 @default.
- W3136743552 cites W2008382495 @default.
- W3136743552 cites W2011337131 @default.
- W3136743552 cites W2026161448 @default.
- W3136743552 cites W2029724130 @default.
- W3136743552 cites W2031593086 @default.
- W3136743552 cites W2032183557 @default.
- W3136743552 cites W2033529357 @default.
- W3136743552 cites W2041607290 @default.
- W3136743552 cites W2043419148 @default.
- W3136743552 cites W2046205086 @default.
- W3136743552 cites W2046269838 @default.
- W3136743552 cites W2049067242 @default.
- W3136743552 cites W2051465794 @default.
- W3136743552 cites W2061869990 @default.
- W3136743552 cites W2063641778 @default.
- W3136743552 cites W2072217545 @default.
- W3136743552 cites W2080840982 @default.
- W3136743552 cites W2085060088 @default.
- W3136743552 cites W2085737527 @default.
- W3136743552 cites W2092803321 @default.
- W3136743552 cites W2096290681 @default.
- W3136743552 cites W2097662406 @default.
- W3136743552 cites W2099291451 @default.
- W3136743552 cites W2102619066 @default.
- W3136743552 cites W2110823023 @default.
- W3136743552 cites W2111609848 @default.
- W3136743552 cites W2114053580 @default.
- W3136743552 cites W2114104545 @default.
- W3136743552 cites W2115016218 @default.
- W3136743552 cites W2122292170 @default.
- W3136743552 cites W2123106337 @default.
- W3136743552 cites W2127826178 @default.
- W3136743552 cites W2130410032 @default.
- W3136743552 cites W2130806458 @default.
- W3136743552 cites W2133167870 @default.
- W3136743552 cites W2137526110 @default.
- W3136743552 cites W2139073409 @default.
- W3136743552 cites W2139993911 @default.
- W3136743552 cites W2146512944 @default.
- W3136743552 cites W2151110836 @default.
- W3136743552 cites W2152334896 @default.
- W3136743552 cites W2158599365 @default.
- W3136743552 cites W2159675211 @default.
- W3136743552 cites W2169002706 @default.
- W3136743552 cites W2191813810 @default.
- W3136743552 cites W2210206421 @default.
- W3136743552 cites W2233158352 @default.
- W3136743552 cites W2322267757 @default.
- W3136743552 cites W2323326409 @default.
- W3136743552 cites W2339742875 @default.
- W3136743552 cites W2510684933 @default.
- W3136743552 cites W2513901369 @default.
- W3136743552 cites W2551899789 @default.
- W3136743552 cites W2607106027 @default.
- W3136743552 cites W2612297280 @default.
- W3136743552 cites W2753584011 @default.
- W3136743552 cites W2766380081 @default.
- W3136743552 cites W2767985110 @default.
- W3136743552 cites W2799094919 @default.
- W3136743552 cites W2803849711 @default.
- W3136743552 cites W2806346859 @default.
- W3136743552 cites W2807333794 @default.
- W3136743552 cites W2807735066 @default.
- W3136743552 cites W2809107133 @default.
- W3136743552 cites W2810563185 @default.
- W3136743552 cites W2822640846 @default.
- W3136743552 cites W2889653359 @default.
- W3136743552 cites W2914381860 @default.
- W3136743552 cites W2915881960 @default.
- W3136743552 cites W2919965388 @default.
- W3136743552 cites W2950543913 @default.
- W3136743552 cites W2951791227 @default.
- W3136743552 cites W2982994561 @default.
- W3136743552 cites W3000146675 @default.
- W3136743552 cites W3092321792 @default.