Matches in SemOpenAlex for { <https://semopenalex.org/work/W313674795> ?p ?o ?g. }
- W313674795 abstract "Background: Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder (FGID) which can be defined as chronic, relapsing visceral pain with bloating associated with change in bowel habit. It affects up to 10-15% of the adult population in the UK and is more common in females. The cost of IBS in terms of health care utilisation is substantial, exceeding �45.6 million per year in the UK alone, yet its pathophysiology is incompletely understood. Visceral pain is the main and most difficult symptom to manage in IBS and many IBS female sufferers compare it to labour pain in its severity. Modulating visceral pain in healthy volunteers and IBS patients is therefore an important research area. Non-invasive magnetic stimulation may play a crucial role in this respect. Aim:The aim of this study is to ascertain whether non-invasive repetitive magnetic stimulation applied to the motor cortex and/or lumbosacrum can modulate gastrointestinal pain originating from the anorectum. Methods:Participants: 16 healthy volunteers and 10 IBS patients aged 18 and above were included in the study.Questionnaires: Healthy volunteers and IBS patients were asked to complete anxiety and depression questionnaire and IBS patients were requested to fill in an IBS severity questionnaire.Motor measurements in healthy subjects: Single-pulse lumbosacral magnetic stimulation (LSMS) was applied to the lumbosacral area for the anal sphincter where the largest motor evoked potential (MEP) amplitude response was detected. Single-pulse transcranial magnetic stimulation (TMS) was then performed at the pre-determined resting motor thresholds (RMT) for the anal sphincter and the hand.Sensory measurements in healthy subjects and IBS patients: Electrical stimulation was used to assess the changes in sensory and pain thresholds in the anorectal area. The subjects were asked to score the pain intensity using five-point categorical rating scales. In addition they were asked to describe the pain experienced using a shortened form of the McGill Pain Questionnaire. Intervention: Healthy volunteers received 6 paradigms of magnetic stimulation in a randomised order i.e. 3 repetitive LSMSs (1 Hz, 10 Hz and sham) and 3 repetitive TMSs (1 Hz, 10 Hz and sham) to investigate their modulatory effects on visceral sensitivity and to determine which of these interventions is most effective. The most effective active interventions (1 Hz rLSMS and 10 Hz rTMS) together with one sham were then trialled in a randomised fashion on IBS patients.Post intervention: Motor excitabilities were repeated at 30 min after each intervention. The assessment of sensory and pain thresholds at anal sphincter and rectum were done immediately, 30 and 60 min after each intervention. Results:Application of 1 Hz rLSMS led to alterations of anal sphincter motor excitabilities and resulted in a significant increase in the amplitude of lumbosacal-anal motor evoked potentials (MEPs) in healthy volunteers recorded at 30 min post intervention. In healthy volunteers, 1 Hz rLSMS and 10 Hz rTMS caused a significant increase in the rectal pain thresholds experienced immediately, 30 and 60 min after each intervention. 10 Hz rLSMS and 1 Hz rTMS only led to a significant rise in rectal pain thresholds immediately after their application. Furthermore, there was a significant increase in the rectal pain thresholds immediately, 30 and 60 min following 1 Hz rLSMS and 10 Hz rTMS in IBS patients. Conclusion:The application of magnetic stimulation to the cortical and lumbosacral areas to modulate visceral pain is a new concept, which reduced rectal sensitivity to painful stimuli and offers a much needed new approach in the management of abdominal pain in patients with IBS." @default.
- W313674795 created "2016-06-24" @default.
- W313674795 creator A5064974990 @default.
- W313674795 date "2012-06-07" @default.
- W313674795 modified "2023-09-28" @default.
- W313674795 title "ALTERATIONS IN HUMAN VISCERAL SENSATION INDUCED BY NON-INVASIVE CORTICAL AND LUMBOSACRAL MAGNETIC STIMULATION IN HEALTH AND DISEASE" @default.
- W313674795 cites W105217970 @default.
- W313674795 cites W1488007422 @default.
- W313674795 cites W1493182874 @default.
- W313674795 cites W1516310948 @default.
- W313674795 cites W1591786816 @default.
- W313674795 cites W1598199649 @default.
- W313674795 cites W1607039173 @default.
- W313674795 cites W163631380 @default.
- W313674795 cites W1883044208 @default.
- W313674795 cites W1910535879 @default.
- W313674795 cites W1951019233 @default.
- W313674795 cites W1965539337 @default.
- W313674795 cites W1965793036 @default.
- W313674795 cites W1967705659 @default.
- W313674795 cites W1967776969 @default.
- W313674795 cites W1970178265 @default.
- W313674795 cites W1970352894 @default.
- W313674795 cites W1970418307 @default.
- W313674795 cites W1971459402 @default.
- W313674795 cites W1975080710 @default.
- W313674795 cites W1976991113 @default.
- W313674795 cites W1978274824 @default.
- W313674795 cites W1979519220 @default.
- W313674795 cites W1981639311 @default.
- W313674795 cites W1983812599 @default.
- W313674795 cites W1983889266 @default.
- W313674795 cites W1988073283 @default.
- W313674795 cites W1988339630 @default.
- W313674795 cites W1989768307 @default.
- W313674795 cites W1991002810 @default.
- W313674795 cites W1991146127 @default.
- W313674795 cites W1995692886 @default.
- W313674795 cites W1996613327 @default.
- W313674795 cites W1998138279 @default.
- W313674795 cites W1998871139 @default.
- W313674795 cites W1999194329 @default.
- W313674795 cites W2001065399 @default.
- W313674795 cites W2002912688 @default.
- W313674795 cites W2003377546 @default.
- W313674795 cites W2005265494 @default.
- W313674795 cites W2006879513 @default.
- W313674795 cites W2007211118 @default.
- W313674795 cites W2008473424 @default.
- W313674795 cites W2008501199 @default.
- W313674795 cites W2009145554 @default.
- W313674795 cites W2010235735 @default.
- W313674795 cites W2011245982 @default.
- W313674795 cites W2011785045 @default.
- W313674795 cites W2011997796 @default.
- W313674795 cites W2012802401 @default.
- W313674795 cites W2013471072 @default.
- W313674795 cites W2014161061 @default.
- W313674795 cites W2014568016 @default.
- W313674795 cites W2014779151 @default.
- W313674795 cites W2016238096 @default.
- W313674795 cites W2021372341 @default.
- W313674795 cites W2022024278 @default.
- W313674795 cites W2023614831 @default.
- W313674795 cites W2024016679 @default.
- W313674795 cites W2024054482 @default.
- W313674795 cites W2024746554 @default.
- W313674795 cites W2025189539 @default.
- W313674795 cites W2025577666 @default.
- W313674795 cites W2025926103 @default.
- W313674795 cites W2025949383 @default.
- W313674795 cites W2026500577 @default.
- W313674795 cites W2026661267 @default.
- W313674795 cites W2027411305 @default.
- W313674795 cites W2028184380 @default.
- W313674795 cites W2030125627 @default.
- W313674795 cites W2030408727 @default.
- W313674795 cites W2032277387 @default.
- W313674795 cites W2033552631 @default.
- W313674795 cites W2034874605 @default.
- W313674795 cites W2035352122 @default.
- W313674795 cites W2039239192 @default.
- W313674795 cites W2039478028 @default.
- W313674795 cites W2041086425 @default.
- W313674795 cites W2041318300 @default.
- W313674795 cites W2043126698 @default.
- W313674795 cites W2044044822 @default.
- W313674795 cites W2045240440 @default.
- W313674795 cites W2045268251 @default.
- W313674795 cites W2045667410 @default.
- W313674795 cites W2049637725 @default.
- W313674795 cites W2050740432 @default.
- W313674795 cites W2051136569 @default.
- W313674795 cites W2052881681 @default.
- W313674795 cites W2055637488 @default.
- W313674795 cites W2055775299 @default.
- W313674795 cites W2058709617 @default.
- W313674795 cites W2058787500 @default.
- W313674795 cites W2060600395 @default.
- W313674795 cites W2060940935 @default.