Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136754634> ?p ?o ?g. }
- W3136754634 endingPage "166959" @default.
- W3136754634 startingPage "166959" @default.
- W3136754634 abstract "The multidrug and toxin extrusion (MATE) transporters catalyze active efflux of a broad range of chemically- and structurally-diverse compounds including antimicrobials and chemotherapeutics, thus contributing to multidrug resistance in pathogenic bacteria and cancers. Multiple methodological approaches have been taken to investigate the structural basis of energy transduction and substrate translocation in MATE transporters. Crystal structures representing members from all three MATE subfamilies have been interpreted within the context of an alternating access mechanism that postulates occupation of distinct structural intermediates in a conformational cycle powered by electrochemical ion gradients. Here we review the structural biology of MATE transporters, integrating the crystallographic models with biophysical and computational studies to define the molecular determinants that shape the transport energy landscape. This holistic analysis highlights both shared and disparate structural and functional features within the MATE family, which underpin an emerging theme of mechanistic diversity within the framework of a conserved structural scaffold." @default.
- W3136754634 created "2021-03-29" @default.
- W3136754634 creator A5024917074 @default.
- W3136754634 creator A5059881003 @default.
- W3136754634 creator A5081420800 @default.
- W3136754634 date "2021-08-01" @default.
- W3136754634 modified "2023-10-14" @default.
- W3136754634 title "Principles of Alternating Access in Multidrug and Toxin Extrusion (MATE) Transporters" @default.
- W3136754634 cites W1508816133 @default.
- W3136754634 cites W1852257267 @default.
- W3136754634 cites W1858175782 @default.
- W3136754634 cites W1911934392 @default.
- W3136754634 cites W1964279528 @default.
- W3136754634 cites W1973921362 @default.
- W3136754634 cites W1992956599 @default.
- W3136754634 cites W1993236717 @default.
- W3136754634 cites W1995500412 @default.
- W3136754634 cites W1997394451 @default.
- W3136754634 cites W1997432723 @default.
- W3136754634 cites W2000687868 @default.
- W3136754634 cites W2001362053 @default.
- W3136754634 cites W2002996832 @default.
- W3136754634 cites W2006407926 @default.
- W3136754634 cites W2006434892 @default.
- W3136754634 cites W2019198879 @default.
- W3136754634 cites W2034886511 @default.
- W3136754634 cites W2034979953 @default.
- W3136754634 cites W2035586500 @default.
- W3136754634 cites W2058981075 @default.
- W3136754634 cites W2061495681 @default.
- W3136754634 cites W2061596566 @default.
- W3136754634 cites W2063469071 @default.
- W3136754634 cites W2064257416 @default.
- W3136754634 cites W2066736637 @default.
- W3136754634 cites W2067800798 @default.
- W3136754634 cites W2079611781 @default.
- W3136754634 cites W2081183202 @default.
- W3136754634 cites W2088095424 @default.
- W3136754634 cites W2095267065 @default.
- W3136754634 cites W2099384461 @default.
- W3136754634 cites W2100027417 @default.
- W3136754634 cites W2101456362 @default.
- W3136754634 cites W2103369433 @default.
- W3136754634 cites W2104622728 @default.
- W3136754634 cites W2112187549 @default.
- W3136754634 cites W2114347076 @default.
- W3136754634 cites W2115202347 @default.
- W3136754634 cites W2115632790 @default.
- W3136754634 cites W2116554892 @default.
- W3136754634 cites W2117692933 @default.
- W3136754634 cites W2120740366 @default.
- W3136754634 cites W2128358586 @default.
- W3136754634 cites W2131624523 @default.
- W3136754634 cites W2132926880 @default.
- W3136754634 cites W2135482362 @default.
- W3136754634 cites W2139177796 @default.
- W3136754634 cites W2143573319 @default.
- W3136754634 cites W2143594787 @default.
- W3136754634 cites W2144468386 @default.
- W3136754634 cites W2147241123 @default.
- W3136754634 cites W2164609892 @default.
- W3136754634 cites W2169438683 @default.
- W3136754634 cites W2195184102 @default.
- W3136754634 cites W2221809773 @default.
- W3136754634 cites W2237107294 @default.
- W3136754634 cites W2256408545 @default.
- W3136754634 cites W2264686850 @default.
- W3136754634 cites W2276180411 @default.
- W3136754634 cites W2300286959 @default.
- W3136754634 cites W2398424531 @default.
- W3136754634 cites W2536223390 @default.
- W3136754634 cites W2560032747 @default.
- W3136754634 cites W2565680183 @default.
- W3136754634 cites W2591156879 @default.
- W3136754634 cites W2597231659 @default.
- W3136754634 cites W2752099522 @default.
- W3136754634 cites W2767084674 @default.
- W3136754634 cites W2770618149 @default.
- W3136754634 cites W2779019546 @default.
- W3136754634 cites W2784113587 @default.
- W3136754634 cites W2793083001 @default.
- W3136754634 cites W2794208885 @default.
- W3136754634 cites W2808307727 @default.
- W3136754634 cites W2809234913 @default.
- W3136754634 cites W2894708945 @default.
- W3136754634 cites W2900776769 @default.
- W3136754634 cites W2902723926 @default.
- W3136754634 cites W2913900430 @default.
- W3136754634 cites W2948339609 @default.
- W3136754634 cites W2961592155 @default.
- W3136754634 cites W2990107056 @default.
- W3136754634 cites W2995123180 @default.
- W3136754634 cites W3007428911 @default.
- W3136754634 cites W3029440251 @default.
- W3136754634 cites W3107946070 @default.
- W3136754634 cites W3120199542 @default.
- W3136754634 cites W4235037735 @default.
- W3136754634 doi "https://doi.org/10.1016/j.jmb.2021.166959" @default.