Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136755124> ?p ?o ?g. }
- W3136755124 abstract "Summary The mucosal chemokine CCL28 is highly upregulated during infection but its role in this context is not well understood. Utilizing Ccl28 -/- mice, we discovered that CCL28 promotes neutrophil recruitment to the infected mucosa. Neutrophils from these tissues expressed the CCL28 receptor CCR3, and CCR3 stimulation enhanced neutrophil antimicrobial activity against Salmonella . Moreover, bone marrow neutrophils harbored pre-formed intracellular CCR3 that was rapidly mobilized to the cell surface following phagocytosis or inflammatory stimuli. The functional consequences of CCL28 deficiency were strikingly different between two infection models, as Ccl28 -/- mice were highly susceptible to Salmonella gut infection, but highly resistant to otherwise lethal Acinetobacter lung infection. CCL28 thus plays a critical role in the immune response to mucosal pathogens by regulating neutrophil recruitment and activation, a response whose ultimate consequence ranges from beneficial (control of the pathogen) to exceedingly negative (death of the host), depending on the infectious agent and impacted organs." @default.
- W3136755124 created "2021-03-29" @default.
- W3136755124 creator A5005181170 @default.
- W3136755124 creator A5011791725 @default.
- W3136755124 creator A5015667911 @default.
- W3136755124 creator A5020734888 @default.
- W3136755124 creator A5024921031 @default.
- W3136755124 creator A5026080952 @default.
- W3136755124 creator A5026517227 @default.
- W3136755124 creator A5041214247 @default.
- W3136755124 creator A5044833035 @default.
- W3136755124 creator A5047045826 @default.
- W3136755124 creator A5055014786 @default.
- W3136755124 creator A5056406805 @default.
- W3136755124 creator A5057610757 @default.
- W3136755124 creator A5067686950 @default.
- W3136755124 creator A5072532781 @default.
- W3136755124 creator A5073764726 @default.
- W3136755124 creator A5083244610 @default.
- W3136755124 date "2021-03-20" @default.
- W3136755124 modified "2023-10-18" @default.
- W3136755124 title "CCL28 modulates neutrophil responses and impacts the trajectory of mucosal infections" @default.
- W3136755124 cites W1485872830 @default.
- W3136755124 cites W1548493038 @default.
- W3136755124 cites W1589692813 @default.
- W3136755124 cites W1968414886 @default.
- W3136755124 cites W1971883379 @default.
- W3136755124 cites W1989744906 @default.
- W3136755124 cites W1992540248 @default.
- W3136755124 cites W1998191004 @default.
- W3136755124 cites W2000707384 @default.
- W3136755124 cites W2004216239 @default.
- W3136755124 cites W2010239869 @default.
- W3136755124 cites W2014124458 @default.
- W3136755124 cites W2016900532 @default.
- W3136755124 cites W2026571365 @default.
- W3136755124 cites W2030689322 @default.
- W3136755124 cites W2031445899 @default.
- W3136755124 cites W2043052840 @default.
- W3136755124 cites W2053872493 @default.
- W3136755124 cites W2061631515 @default.
- W3136755124 cites W2063541345 @default.
- W3136755124 cites W2074883153 @default.
- W3136755124 cites W2075756658 @default.
- W3136755124 cites W2088135692 @default.
- W3136755124 cites W2094735775 @default.
- W3136755124 cites W2096760010 @default.
- W3136755124 cites W2101350279 @default.
- W3136755124 cites W2103140795 @default.
- W3136755124 cites W2113861222 @default.
- W3136755124 cites W2118203401 @default.
- W3136755124 cites W2121891913 @default.
- W3136755124 cites W2124519481 @default.
- W3136755124 cites W2143401494 @default.
- W3136755124 cites W2148586366 @default.
- W3136755124 cites W2155705367 @default.
- W3136755124 cites W2164360628 @default.
- W3136755124 cites W2165539495 @default.
- W3136755124 cites W2168777273 @default.
- W3136755124 cites W2168812240 @default.
- W3136755124 cites W2170391333 @default.
- W3136755124 cites W2276961144 @default.
- W3136755124 cites W2339478720 @default.
- W3136755124 cites W2606987373 @default.
- W3136755124 cites W2753345042 @default.
- W3136755124 cites W2773136482 @default.
- W3136755124 cites W2797069917 @default.
- W3136755124 cites W2905994814 @default.
- W3136755124 cites W2921488449 @default.
- W3136755124 cites W2939209922 @default.
- W3136755124 cites W2952481429 @default.
- W3136755124 cites W2964202280 @default.
- W3136755124 cites W3007019685 @default.
- W3136755124 cites W3010538497 @default.
- W3136755124 cites W3012097929 @default.
- W3136755124 cites W3020481328 @default.
- W3136755124 cites W3021393314 @default.
- W3136755124 cites W3022888330 @default.
- W3136755124 cites W3026927696 @default.
- W3136755124 cites W3046383992 @default.
- W3136755124 cites W3081143013 @default.
- W3136755124 cites W3084924559 @default.
- W3136755124 cites W3085958090 @default.
- W3136755124 cites W4250676629 @default.
- W3136755124 cites W97158386 @default.
- W3136755124 doi "https://doi.org/10.1101/2021.03.19.436197" @default.
- W3136755124 hasPublicationYear "2021" @default.
- W3136755124 type Work @default.
- W3136755124 sameAs 3136755124 @default.
- W3136755124 citedByCount "0" @default.
- W3136755124 crossrefType "posted-content" @default.
- W3136755124 hasAuthorship W3136755124A5005181170 @default.
- W3136755124 hasAuthorship W3136755124A5011791725 @default.
- W3136755124 hasAuthorship W3136755124A5015667911 @default.
- W3136755124 hasAuthorship W3136755124A5020734888 @default.
- W3136755124 hasAuthorship W3136755124A5024921031 @default.
- W3136755124 hasAuthorship W3136755124A5026080952 @default.
- W3136755124 hasAuthorship W3136755124A5026517227 @default.
- W3136755124 hasAuthorship W3136755124A5041214247 @default.
- W3136755124 hasAuthorship W3136755124A5044833035 @default.