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- W3136755667 abstract "Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by the presence of α-synuclein (α-Syn)-rich Lewy bodies (LBs) and the preferential loss of dopaminergic (DA) neurons in the substantia nigra (SN) pars compacta (SNpc). However, the widespread involvement of other central nervous systems (CNS) structures and peripheral tissues is now widely documented. The onset of the molecular and cellular neuropathology of PD likely occurs decades before the onset of the motor symptoms characteristic of PD, so early diagnosis of PD and adequate tracking of disease progression could significantly improve outcomes for patients. Because the clinical diagnosis of PD is challenging, misdiagnosis is common, which highlights the need for disease-specific and early-stage biomarkers. This review article aims to summarize useful biomarkers for the diagnosis of PD, as well as the biomarkers used to monitor disease progression. This review article describes the role of α-Syn in PD and how it could potentially be used as a biomarker for PD. Also, preclinical and clinical investigations encompassing genetics, immunology, fluid and tissue, imaging, as well as neurophysiology biomarkers are discussed. Knowledge of the novel biomarkers for preclinical detection and clinical evaluation will contribute to a deeper understanding of the disease mechanism, which should more effectively guide clinical applications." @default.
- W3136755667 created "2021-03-29" @default.
- W3136755667 creator A5009709929 @default.
- W3136755667 creator A5038016021 @default.
- W3136755667 creator A5039154845 @default.
- W3136755667 creator A5042450328 @default.
- W3136755667 creator A5042800587 @default.
- W3136755667 creator A5072458816 @default.
- W3136755667 date "2021-03-23" @default.
- W3136755667 modified "2023-10-17" @default.
- W3136755667 title "Biomarkers and the Role of α-Synuclein in Parkinson’s Disease" @default.
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