FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136755952> ?p ?o ?g. }

• W3136755952 endingPage "3099" @default.
• W3136755952 startingPage "3099" @default.
• W3136755952 abstract "3099 Objectives: Previously, we compared the suitability of the cerebellum and pons as a reference region for quantitative evaluation on brain PET images in Alzheimer’s disease (AD) using 11C-Pittsburgh Compound-B (11C-PiB). However, we set the volumes of interest (VOIs) manually in the cerebellum and pons as reference regions and frontal and temporal cortex as regions of interest (ROIs). Therefore, it is possible that the VOIs may not have been set accurately. For instance, the regions outside the cortical regions may be contained as specific accumulation areas in VOIs. It is imperative to measure standardized uptake value ratio (SUVR) by setting the VOIs automatically using MRI images and a relevant imaging software. Additionally, SUVR is reportedly better correlated with clinical symptoms when using the white matter as the reference region. Therefore, this study aimed to compare different potential reference regions (the pons, cerebellum, cerebellum + pons or white matter) to identify the most suitable among them using MRI and software. Methods: We retrospectively evaluated the data of 13 AD patients and 17 healthy controls (HCs). We used the PMOD software (PMOD Technologies Ltd.) to set the VOIs in the pons, cerebellum, white matter, frontal cortex, temporal cortex, parietal cortex, and occipital cortex. They were automatically adjusted according to the individual patient’s anatomy, which was visualized via T1-MR images, using a spatial normalization procedure. These VOIs were set to measure the mean of SUV values (SUVmean) and the maximum SUV values (SUVmax) in a VOI. SUVmean and SUVmax values for the pons, cerebellum, cerebellum + pons, and white matter between AD patients and HCs were compared using a t-test. SUVR was then measured using these different reference regions for a variety of ROIs, including the frontal cortex, temporal cortex, parietal cortex, and occipital cortex. These values between AD patients and HCs were subsequently compared using a t-test. Results: Both SUVmean and SUVmax of the pons, cerebellum, cerebellum + pons were similar; however, we noted significant differences between AD patients and HCs in those of the white matter (p<0.01). There were significant differences between the SUVRs of AD patients and HCs in each of the reference regions examined (p<0.01). Therefore, the outcomes suggested that all of these reference regions were suitable to be used for analysis. Furthermore, the greatest difference in values between AD patients and HCs could be identified using SUVmean with the cerebellum as the reference region. Conclusions: The pons, cerebellum, cerebellum + pons, and white matter can all be used as suitable reference regions in the measurement of SUVR. This study also suggested that a more accurate quantitative evaluation can be performed if SUVmean is determined using the cerebellum as the reference region." @default.
• W3136755952 created "2021-03-29" @default.
• W3136755952 creator A5010709572 @default.
• W3136755952 creator A5011192254 @default.
• W3136755952 creator A5036994563 @default.
• W3136755952 creator A5040742819 @default.
• W3136755952 creator A5052758613 @default.
• W3136755952 creator A5062835440 @default.
• W3136755952 creator A5072027266 @default.
• W3136755952 creator A5072345731 @default.
• W3136755952 date "2020-05-01" @default.
• W3136755952 modified "2023-09-28" @default.
• W3136755952 title "Comparative Study of Various Reference Regions for Standardized Uptake Value Ratio Using11C-Pittsburgh Compound-B PET and MR Images" @default.
• W3136755952 hasPublicationYear "2020" @default.
• W3136755952 type Work @default.
• W3136755952 sameAs 3136755952 @default.
• W3136755952 citedByCount "0" @default.
• W3136755952 crossrefType "journal-article" @default.
• W3136755952 hasAuthorship W3136755952A5010709572 @default.
• W3136755952 hasAuthorship W3136755952A5011192254 @default.
• W3136755952 hasAuthorship W3136755952A5036994563 @default.
• W3136755952 hasAuthorship W3136755952A5040742819 @default.
• W3136755952 hasAuthorship W3136755952A5052758613 @default.
• W3136755952 hasAuthorship W3136755952A5062835440 @default.
• W3136755952 hasAuthorship W3136755952A5072027266 @default.
• W3136755952 hasAuthorship W3136755952A5072345731 @default.
• W3136755952 hasConcept C126838900 @default.
• W3136755952 hasConcept C143409427 @default.
• W3136755952 hasConcept C15744967 @default.
• W3136755952 hasConcept C169760540 @default.
• W3136755952 hasConcept C199374082 @default.
• W3136755952 hasConcept C2775842073 @default.
• W3136755952 hasConcept C2777348757 @default.
• W3136755952 hasConcept C2778897929 @default.
• W3136755952 hasConcept C2779652256 @default.
• W3136755952 hasConcept C2781192897 @default.
• W3136755952 hasConcept C2983163835 @default.
• W3136755952 hasConcept C2989005 @default.
• W3136755952 hasConcept C2992333117 @default.
• W3136755952 hasConcept C2993858690 @default.
• W3136755952 hasConcept C71924100 @default.
• W3136755952 hasConceptScore W3136755952C126838900 @default.
• W3136755952 hasConceptScore W3136755952C143409427 @default.
• W3136755952 hasConceptScore W3136755952C15744967 @default.
• W3136755952 hasConceptScore W3136755952C169760540 @default.
• W3136755952 hasConceptScore W3136755952C199374082 @default.
• W3136755952 hasConceptScore W3136755952C2775842073 @default.
• W3136755952 hasConceptScore W3136755952C2777348757 @default.
• W3136755952 hasConceptScore W3136755952C2778897929 @default.
• W3136755952 hasConceptScore W3136755952C2779652256 @default.
• W3136755952 hasConceptScore W3136755952C2781192897 @default.
• W3136755952 hasConceptScore W3136755952C2983163835 @default.
• W3136755952 hasConceptScore W3136755952C2989005 @default.
• W3136755952 hasConceptScore W3136755952C2992333117 @default.
• W3136755952 hasConceptScore W3136755952C2993858690 @default.
• W3136755952 hasConceptScore W3136755952C71924100 @default.
• W3136755952 hasLocation W31367559521 @default.
• W3136755952 hasOpenAccess W3136755952 @default.
• W3136755952 hasPrimaryLocation W31367559521 @default.
• W3136755952 hasRelatedWork W2035969994 @default.
• W3136755952 hasRelatedWork W2060887411 @default.
• W3136755952 hasRelatedWork W2080531304 @default.
• W3136755952 hasRelatedWork W2095703384 @default.
• W3136755952 hasRelatedWork W2143685309 @default.
• W3136755952 hasRelatedWork W2391008689 @default.
• W3136755952 hasRelatedWork W2392459194 @default.
• W3136755952 hasRelatedWork W2594520623 @default.
• W3136755952 hasRelatedWork W2599588857 @default.
• W3136755952 hasRelatedWork W2753311775 @default.
• W3136755952 hasRelatedWork W2896268981 @default.
• W3136755952 hasRelatedWork W2948070289 @default.
• W3136755952 hasRelatedWork W2948632665 @default.
• W3136755952 hasRelatedWork W2971798702 @default.
• W3136755952 hasRelatedWork W3029097366 @default.
• W3136755952 hasRelatedWork W3091882765 @default.
• W3136755952 hasRelatedWork W3160923525 @default.
• W3136755952 hasRelatedWork W3164205364 @default.
• W3136755952 hasRelatedWork W3165347251 @default.
• W3136755952 hasRelatedWork W71893479 @default.
• W3136755952 hasVolume "61" @default.
• W3136755952 isParatext "false" @default.
• W3136755952 isRetracted "false" @default.
• W3136755952 magId "3136755952" @default.
• W3136755952 workType "article" @default.