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- W3136755972 abstract "Background : Signal transducer and activator of transcription 4 ( STAT4 ) mediates the intracellular effects of interleukin-12, leading to the production of interferon gamma (IFN-γ) and natural killer (NK) cells cytotoxicity. However, the clinical significance of STAT4 expression in patients with hepatocellular carcinoma (HCC) remains virtually unknown. Methods: A total of 66 HCC patients who underwent hepatectomy were enrolled in this study. Quantitative real-time polymerase chain reaction was performed to determine STAT4 and IFNG mRNA expression levels. Tissue microarray-based immunohistochemistry was performed to examine CD8 + T cells, STAT4 and INF- γ. Results: STAT4 was differentially expressed in tumor and non-tumor tissues ( P = 0.001), and positively correlated with IFNG expression ( R 2 = 0.506, P < 0.05) and CD8 + T-cell infiltration ( R 2 = 0.530, P < 0.001). Significant correlations were observed between STAT4 expression and tumor TNM stage ( P = 0.043), hepatic venous invasion( P = 0.003), des-gamma-carboxy prothrombin ( P = 0.011), tumor size ( P = 0.036), and tumor differentiation ( P = 0.034). Patients with high STAT4 expressionhad significantly better recurrence-free survival ( P = 0.009). Low STAT4 expression ( P = 0.030) and presence of portal venous invasion or hepatic venous invasion ( P = 0.006) were independent risk factors for HCC recurrence. Conclusions: Downregulation of STAT4 in HCC indicated aggressive tumor behavior and predicted a worse clinical outcome. STAT4 might be a useful biomarker to identify patients at high risk of recurrence after hepatectomy." @default.
- W3136755972 created "2021-03-29" @default.
- W3136755972 creator A5046039302 @default.
- W3136755972 date "2017-01-03" @default.
- W3136755972 modified "2023-09-23" @default.
- W3136755972 title "The role of Signal transducer and activator of transcription 4 expression in viral and non-viral causes of liver cancer and its correlation with cellular immun ity" @default.
- W3136755972 hasPublicationYear "2017" @default.
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