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• W3136756699 abstract "To observe and compare the effects of peptides on the repair of rabbit skull defects through two different binding modes of non-covalent and covalent, and the combination of carboxyl (-COOH) and amino (-NH 2) groups with materials.Twenty-one 3-month-old male ordinary New Zealand white rabbits were numbered 1 to 42 on the left and right parietal bones. They were divided into 5 groups using a random number table, the control group (group A, 6 sides) and the material group 1, 2, 3, 4 (respectively group B, C, D, E, 9 sides in each group). All animals were prepared with 12-mm-diameter skull defect models, and bone morphogenetic protein 2 (BMP-2) non-covalently bound multiwalled carbon nanotubes (MWCNT)-COOH+poly ( L-lactide) (PLLA), BMP-2 non-covalently bound MWCNT-NH 2+PLLA, BMP-2 covalently bound MWCNT-COOH+PLLA, and BMP-2 covalently bound MWCNT-NH 2+PLLA were implanted into the defects of groups B, C, D, and E, respectively. At 4, 8, and 12 weeks after operation, the samples were taken for CT scanning and three-dimensional reconstruction, the ratio of bone tissue regeneration volume to total volume and bone mineral density were measured, and the histological observation of HE staining and Masson trichrome staining were performed to quantitatively analyze the volume ratio of new bone tissue.CT scanning and three-dimensional reconstruction showed that with the extension of time, the defects in groups A-E were filled gradually, and the defect in group E was completely filled at 12 weeks after operation. HE staining and Masson trichrome staining showed that the volume of new bone tissue in each group gradually increased with time, and regenerated mature bone tissue appeared in groups D and E at 12 weeks after operation. Quantitative analysis showed that at 4, 8, and 12 weeks after operation, the ratio of bone tissue regeneration volume to total volume, bone mineral density, and the volume ratio of new bone tissue increased gradually over time; and at each time point, the above indexes increased gradually from group A to group E, and the differences between groups were significant ( P<0.05).Through covalent binding and using -NH 2 to bound peptides with materials, the best bone repair effect can be achieved.观察并比较多肽通过非共价与共价两种不同结合方式，以及利用羧基（-COOH）和氨基（-NH 2）两种不同官能团与材料结合，对兔颅骨缺损修复效果的影响。.3 月龄雄性普通级新西兰白兔 21 只，将左右两侧顶骨编号 1～42 号，采用随机数字表法分为 5 组，对照组（A 组，6 侧）及材料 1、2、3、4 组（分别为 B、C、D、E 组，每组 9 侧）。所有动物均制备直径 12 mm 颅骨缺损模型，分别将 BMP-2 非共价结合的多壁碳纳米管（multi-walled carbon nanotubes，MWCNT）-COOH+左旋聚乳酸［poly（ L-lactide），PLLA］、BMP-2 非共价结合的 MWCNT-NH 2+PLLA、BMP-2 共价结合的 MWCNT-COOH+PLLA、BMP-2 共价结合的 MWCNT-NH 2+PLLA 植入 B、C、D、E 组缺损区。术后 4、8、12 周取材行 CT扫描及三维重建观察，定量分析骨组织再生体积与总体积比值并测量骨密度值；样本切片行 HE 染色和 Masson 三色染色组织学观察，定量分析新生骨组织体积比。.CT 扫描及三维重建观察示，随时间延长，A～E 组骨缺损被逐渐填充，术后 12 周时 E 组骨缺损被完全填充。HE 染色和 Masson 三色染色示，随时间延长，各组新生骨组织体积逐渐增大，术后 12 周 D、E 组出现了再生成熟骨组织。定量分析显示，术后 4、8、12 周，各组骨组织再生体积与总体积比值、骨密度值、新生骨组织体积比随时间增加均呈逐渐增加趋势；且各时间点从 A～E 组也呈逐渐增加趋势，组间两两比较差异均有统计学意义（ P<0.05）。.通过共价结合方式并利用 -NH 2 将多肽与材料相结合，可以实现最好的骨修复效果。." @default.
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• W3136756699 date "2021-03-15" @default.
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• W3136756699 title "[Experimental study on repairing rabbit skull defect with bone morphogenetic protein 2 peptide/functionalized carbon nanotube composite]." @default.
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• W3136756699 doi "https://doi.org/10.7507/1002-1892.202009014" @default.
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