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• W3136757027 startingPage "e1009436" @default.
• W3136757027 abstract "Opportunistic pathogens frequently cause volatile infections in hosts with compromised immune systems or a disrupted normal microbiota. The commensalism of diverse microorganisms contributes to colonization resistance, which prevents the expansion of opportunistic pathogens. Following microbiota disruption, pathogens promptly adapt to altered niches and obtain growth advantages. Nevertheless, whether and how resident bacteria modulate the growth dynamics of invasive pathogens and the eventual outcome of such infections are still unclear. Here, we utilized birds as a model animal and observed a resident bacterium exacerbating the invasion of Avibacterium paragallinarum (previously Haemophilus paragallinarum ) in the respiratory tract. We first found that negligibly abundant Staphylococcus chromogenes , rather than Staphylococcus aureus , played a dominant role in Av . paragallinarum -associated infectious coryza in poultry based on epidemic investigations and in vitro analyses. Furthermore, we determined that S . chromogenes not only directly provides the necessary nutrition factor nicotinamide adenine dinucleotide (NAD + ) but also accelerates its biosynthesis and release from host cells to promote the survival and growth of Av . paragallinarum . Last, we successfully intervened in Av . paragallinarum -associated infections in animal models using antibiotics that specifically target S . chromogenes . Our findings show that opportunistic pathogens can hijack commensal bacteria to initiate infection and expansion and suggest a new paradigm to ameliorate opportunistic infections by modulating the dynamics of resident bacteria." @default.
• W3136757027 created "2021-03-29" @default.
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• W3136757027 date "2021-03-19" @default.
• W3136757027 modified "2023-10-12" @default.
• W3136757027 title "Resident bacteria contribute to opportunistic infections of the respiratory tract" @default.
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• W3136757027 doi "https://doi.org/10.1371/journal.ppat.1009436" @default.
• W3136757027 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8011790" @default.
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• W3136757027 hasPublicationYear "2021" @default.
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