Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136759110> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W3136759110 endingPage "16" @default.
- W3136759110 startingPage "9" @default.
- W3136759110 abstract "The RNA-binding protein Ataxin-2 regulates translation and mRNA stability through cytoplasmic polyadenylation of the targets. Here we newly identified DDX6 as a positive regulator of the cytoplasmic polyadenylation. Analysis of Ataxin-2 interactome using LC-MS/MS revealed prominent interaction with the DEAD-box RNA helicase DDX6. DDX6 interacted with components of the Ataxin-2 polyadenylation machinery; Ataxin-2, PABPC1 and PAPD4. As in the case for Ataxin-2 downregulation, DDX6 downregulation led to an increase in Ataxin-2 target mRNAs with short poly(A) tails as well as a reduction in their protein expression. In contrast, Ataxin-2 target mRNAs with short poly(A) tails were decreased by the overexpression of Ataxin-2, which was compromised by the DDX6 downregulation. However, polyadenylation induced by Ataxin-2 tethering was not affected by the DDX6 downregulation. Taken together, these results suggest that DDX6 positively regulates Ataxin-2-induced cytoplasmic polyadenylation to maintain poly(A) tail length of the Ataxin-2 targets provably through accelerating binding of Ataxin-2 to the target mRNAs." @default.
- W3136759110 created "2021-03-29" @default.
- W3136759110 creator A5010812560 @default.
- W3136759110 creator A5038295001 @default.
- W3136759110 creator A5041182813 @default.
- W3136759110 date "2021-05-01" @default.
- W3136759110 modified "2023-10-17" @default.
- W3136759110 title "DDX6 is a positive regulator of Ataxin-2/PAPD4 cytoplasmic polyadenylation machinery" @default.
- W3136759110 cites W1974005002 @default.
- W3136759110 cites W1974676736 @default.
- W3136759110 cites W1996157637 @default.
- W3136759110 cites W2006898408 @default.
- W3136759110 cites W2021744893 @default.
- W3136759110 cites W2035056945 @default.
- W3136759110 cites W2037175112 @default.
- W3136759110 cites W2047770989 @default.
- W3136759110 cites W2130386199 @default.
- W3136759110 cites W2132397441 @default.
- W3136759110 cites W2146999892 @default.
- W3136759110 cites W2169158245 @default.
- W3136759110 cites W2291046361 @default.
- W3136759110 cites W2461878290 @default.
- W3136759110 cites W2620919859 @default.
- W3136759110 cites W2899760200 @default.
- W3136759110 cites W2903569556 @default.
- W3136759110 cites W3089922438 @default.
- W3136759110 doi "https://doi.org/10.1016/j.bbrc.2021.03.066" @default.
- W3136759110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33756349" @default.
- W3136759110 hasPublicationYear "2021" @default.
- W3136759110 type Work @default.
- W3136759110 sameAs 3136759110 @default.
- W3136759110 citedByCount "1" @default.
- W3136759110 countsByYear W31367591102022 @default.
- W3136759110 crossrefType "journal-article" @default.
- W3136759110 hasAuthorship W3136759110A5010812560 @default.
- W3136759110 hasAuthorship W3136759110A5038295001 @default.
- W3136759110 hasAuthorship W3136759110A5041182813 @default.
- W3136759110 hasConcept C104317684 @default.
- W3136759110 hasConcept C142575336 @default.
- W3136759110 hasConcept C185592680 @default.
- W3136759110 hasConcept C190062978 @default.
- W3136759110 hasConcept C3017707949 @default.
- W3136759110 hasConcept C54355233 @default.
- W3136759110 hasConcept C62478195 @default.
- W3136759110 hasConcept C67705224 @default.
- W3136759110 hasConcept C6929976 @default.
- W3136759110 hasConcept C86803240 @default.
- W3136759110 hasConcept C95444343 @default.
- W3136759110 hasConceptScore W3136759110C104317684 @default.
- W3136759110 hasConceptScore W3136759110C142575336 @default.
- W3136759110 hasConceptScore W3136759110C185592680 @default.
- W3136759110 hasConceptScore W3136759110C190062978 @default.
- W3136759110 hasConceptScore W3136759110C3017707949 @default.
- W3136759110 hasConceptScore W3136759110C54355233 @default.
- W3136759110 hasConceptScore W3136759110C62478195 @default.
- W3136759110 hasConceptScore W3136759110C67705224 @default.
- W3136759110 hasConceptScore W3136759110C6929976 @default.
- W3136759110 hasConceptScore W3136759110C86803240 @default.
- W3136759110 hasConceptScore W3136759110C95444343 @default.
- W3136759110 hasFunder F4320309807 @default.
- W3136759110 hasFunder F4320311405 @default.
- W3136759110 hasFunder F4320334764 @default.
- W3136759110 hasLocation W31367591101 @default.
- W3136759110 hasOpenAccess W3136759110 @default.
- W3136759110 hasPrimaryLocation W31367591101 @default.
- W3136759110 hasRelatedWork W1906987347 @default.
- W3136759110 hasRelatedWork W2000868275 @default.
- W3136759110 hasRelatedWork W2017357304 @default.
- W3136759110 hasRelatedWork W2020530697 @default.
- W3136759110 hasRelatedWork W2022380234 @default.
- W3136759110 hasRelatedWork W2073661771 @default.
- W3136759110 hasRelatedWork W2204390533 @default.
- W3136759110 hasRelatedWork W2416815615 @default.
- W3136759110 hasRelatedWork W2987358025 @default.
- W3136759110 hasRelatedWork W3178209818 @default.
- W3136759110 hasVolume "553" @default.
- W3136759110 isParatext "false" @default.
- W3136759110 isRetracted "false" @default.
- W3136759110 magId "3136759110" @default.
- W3136759110 workType "article" @default.