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- W3136759857 abstract "The prognosis and treatment outcomes of heart failure patients rely on patient etiology yet the underlying signaling mechanisms are complex and not fully elucidated. Phosphorylation is a major form of protein regulation, profoundly altering signaling networks. Here, we identified disease-specific regulation of signaling pathways between dilated (DCM) and ischemic (ICM) cardiomyopathies as well as regional differences within infarcted hearts. Myocardial tissues were explanted from DCM patients, infarct, peri-, and non-infarct regions of ICM patients, and non-failing controls (NFC). Following phosphorylated peptide enrichment, peptide fractions were subjected to liquid chromatography-tandem mass spectrometry for global proteomic and phosphoproteomics profiling. Differential protein and pathway analyses were performed to determine protein expression, phosphorylation, and pathways that were significantly altered in pair-wise comparisons (DCM vs. NFC, infarct vs. non-infarct, and peri- vs. non-infarct). This comprehensive study presents novel findings on disease-specific regulation of molecular pathways in heart failure to reveal suitable targets for therapeutic interventions.%%%%M.Sc.%%%%2020-11-20 00:00:00" @default.
- W3136759857 created "2021-03-29" @default.
- W3136759857 creator A5042090068 @default.
- W3136759857 date "2019-11-01" @default.
- W3136759857 modified "2023-09-27" @default.
- W3136759857 title "Global Proteomics and Phosphoproteomics of Heart Failure Patients Elucidate Etiology-specific Signaling" @default.
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