FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136761903> ?p ?o ?g. }

• W3136761903 endingPage "120769" @default.
• W3136761903 startingPage "120769" @default.
• W3136761903 abstract "Craniosynostosis is a debilitating birth defect characterized by the premature fusion of cranial bones resulting from premature loss of stem cells located in suture tissue between growing bones. Mesenchymal stromal cells in long bone and the cranial suture are known to be multipotent cell sources in the appendicular skeleton and cranium, respectively. We are developing biomaterial constructs to maintain stemness of the cranial suture cell population towards an ultimate goal of diminishing craniosynostosis patient morbidity. Recent evidence suggests that physical features of synthetic tissue engineering scaffolds modulate cell and tissue fate. In this study, macroporous tissue engineering scaffolds with well-controlled spherical pores were fabricated by a sugar porogen template method. Cell-scaffold constructs were implanted subcutaneously in mice for up to eight weeks then assayed for mineralization, vascularization, extracellular matrix composition, and gene expression. Pore size differentially regulates cell fate, where sufficiently large pores provide an osteogenic niche adequate for bone formation, while sufficiently small pores (<125 μm in diameter) maintain stemness and prevent differentiation. Cell-scaffold constructs cultured in vitro followed the same pore size-controlled differentiation fate. We therefore attribute the differential cell and tissue fate to scaffold pore geometry. Scaffold pore size regulates mesenchymal cell fate, providing a novel design motif to control tissue regenerative processes and develop mesenchymal stem cell niches in vivo and in vitro through biophysical features." @default.
• W3136761903 created "2021-03-29" @default.
• W3136761903 creator A5017020650 @default.
• W3136761903 creator A5044375817 @default.
• W3136761903 creator A5045335825 @default.
• W3136761903 creator A5045839676 @default.
• W3136761903 creator A5059882947 @default.
• W3136761903 creator A5064762926 @default.
• W3136761903 creator A5068805457 @default.
• W3136761903 creator A5077444654 @default.
• W3136761903 creator A5088948987 @default.
• W3136761903 date "2021-05-01" @default.
• W3136761903 modified "2023-10-10" @default.
• W3136761903 title "Macropore design of tissue engineering scaffolds regulates mesenchymal stem cell differentiation fate" @default.
• W3136761903 cites W1495854911 @default.
• W3136761903 cites W1520210099 @default.
• W3136761903 cites W1850994773 @default.
• W3136761903 cites W1912039399 @default.
• W3136761903 cites W1928785183 @default.
• W3136761903 cites W1964855371 @default.
• W3136761903 cites W1966455164 @default.
• W3136761903 cites W1969464013 @default.
• W3136761903 cites W1972222251 @default.
• W3136761903 cites W1978424120 @default.
• W3136761903 cites W1980958926 @default.
• W3136761903 cites W1990517924 @default.
• W3136761903 cites W1992365767 @default.
• W3136761903 cites W1996623272 @default.
• W3136761903 cites W2015160664 @default.
• W3136761903 cites W2035812542 @default.
• W3136761903 cites W2037680071 @default.
• W3136761903 cites W2038222327 @default.
• W3136761903 cites W2040810212 @default.
• W3136761903 cites W2046072419 @default.
• W3136761903 cites W2050107109 @default.
• W3136761903 cites W2050395164 @default.
• W3136761903 cites W2068588713 @default.
• W3136761903 cites W2074009641 @default.
• W3136761903 cites W2083669301 @default.
• W3136761903 cites W2091463111 @default.
• W3136761903 cites W2111017388 @default.
• W3136761903 cites W2126607218 @default.
• W3136761903 cites W2133557011 @default.
• W3136761903 cites W2141312569 @default.
• W3136761903 cites W2147288638 @default.
• W3136761903 cites W2152150200 @default.
• W3136761903 cites W2159210886 @default.
• W3136761903 cites W2163329006 @default.
• W3136761903 cites W2168789685 @default.
• W3136761903 cites W2169065234 @default.
• W3136761903 cites W2169220031 @default.
• W3136761903 cites W2170489122 @default.
• W3136761903 cites W2337551518 @default.
• W3136761903 cites W2338696171 @default.
• W3136761903 cites W2417191518 @default.
• W3136761903 cites W2475478456 @default.
• W3136761903 cites W2490448638 @default.
• W3136761903 cites W2546444096 @default.
• W3136761903 cites W2588534180 @default.
• W3136761903 cites W2610364597 @default.
• W3136761903 cites W2794355152 @default.
• W3136761903 cites W2886833726 @default.
• W3136761903 cites W2896109846 @default.
• W3136761903 cites W2897084149 @default.
• W3136761903 cites W2954785733 @default.
• W3136761903 cites W2969624724 @default.
• W3136761903 cites W3016023750 @default.
• W3136761903 cites W3029388047 @default.
• W3136761903 cites W3118244582 @default.
• W3136761903 cites W2094718601 @default.
• W3136761903 doi "https://doi.org/10.1016/j.biomaterials.2021.120769" @default.
• W3136761903 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8068670" @default.
• W3136761903 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33798961" @default.
• W3136761903 hasPublicationYear "2021" @default.
• W3136761903 type Work @default.
• W3136761903 sameAs 3136761903 @default.
• W3136761903 citedByCount "43" @default.
• W3136761903 countsByYear W31367619032021 @default.
• W3136761903 countsByYear W31367619032022 @default.
• W3136761903 countsByYear W31367619032023 @default.
• W3136761903 crossrefType "journal-article" @default.
• W3136761903 hasAuthorship W3136761903A5017020650 @default.
• W3136761903 hasAuthorship W3136761903A5044375817 @default.
• W3136761903 hasAuthorship W3136761903A5045335825 @default.
• W3136761903 hasAuthorship W3136761903A5045839676 @default.
• W3136761903 hasAuthorship W3136761903A5059882947 @default.
• W3136761903 hasAuthorship W3136761903A5064762926 @default.
• W3136761903 hasAuthorship W3136761903A5068805457 @default.
• W3136761903 hasAuthorship W3136761903A5077444654 @default.
• W3136761903 hasAuthorship W3136761903A5088948987 @default.
• W3136761903 hasBestOaLocation W31367619032 @default.
• W3136761903 hasConcept C104317684 @default.
• W3136761903 hasConcept C136229726 @default.
• W3136761903 hasConcept C148738053 @default.
• W3136761903 hasConcept C163952510 @default.
• W3136761903 hasConcept C189165786 @default.
• W3136761903 hasConcept C192562407 @default.
• W3136761903 hasConcept C198826908 @default.

• next